EKU NSC 830 Adv Pharm exam questions
|\ |\ |\ |\ |\ |\ |\
with answers
|\
Distribution - CORRECT ANSWERS ✔✔Drug movement from the
|\ |\ |\ |\ |\ |\ |\ |\
blood to tissues and cells
|\ |\ |\ |\
What is Distribution Affected by? - CORRECT ANSWERS ✔✔Protein
|\ |\ |\ |\ |\ |\ |\ |\
binding, blood flow to the tissues, ability of the drug to exit the
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
vascular space, and the ability of the drug to enter the cell
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
What do most drugs bind with - CORRECT ANSWERS ✔✔plasma
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
protein - albumin|\ |\
What does plasma protein albumin do after binding w drugs -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔acts as a carrier
|\ |\ |\ |\ |\
Bound drug molecules are considered - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\
✔✔inactive
Unbound/Free drug molecules are considered - CORRECT
|\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔active |\
What portion of the drug acts on body cells - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔the free or unbound portion
|\ |\ |\ |\ |\
, If a drug molecules is bound to plasma protein, why is it
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
considered inactive? - CORRECT ANSWERS ✔✔It is too big to |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
cross over into the tissues from the plasma
|\ |\ |\ |\ |\ |\ |\
In order for drugs to cross the Blood Brain Barrier they must be: -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Un-ionized, small molecules, and lipid
|\ |\ |\ |\ |\ |\ |\ |\
soluable
in order for drugs to pass the placental barrier they must be: -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Lipid soluable, smaller molecule drugs,
|\ |\ |\ |\ |\ |\ |\
and there must be passive diffusion
|\ |\ |\ |\ |\
Metabolism - CORRECT ANSWERS ✔✔the process of chemically |\ |\ |\ |\ |\ |\ |\ |\
changing a drug to a different compound called a metabolite
|\ |\ |\ |\ |\ |\ |\ |\ |\
What are active drugs changed into in order to be excreted? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔one or more inactive metabolites |\ |\ |\ |\ |\ |\
A function of Metabolism: - CORRECT ANSWERS ✔✔Changing
|\ |\ |\ |\ |\ |\ |\ |\
from an active metabolite to an inactive metabolite OR changing
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
from an inactive metabolite to an active metabolite.
|\ |\ |\ |\ |\ |\ |\
If a drug is administered as an inactive pro-drug what must
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
happen for the drug to have an effect? - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔The drug must be metabolized to an active metabolite from
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
the inactive pro-drug state to have an effect
|\ |\ |\ |\ |\ |\ |\
|\ |\ |\ |\ |\ |\ |\
with answers
|\
Distribution - CORRECT ANSWERS ✔✔Drug movement from the
|\ |\ |\ |\ |\ |\ |\ |\
blood to tissues and cells
|\ |\ |\ |\
What is Distribution Affected by? - CORRECT ANSWERS ✔✔Protein
|\ |\ |\ |\ |\ |\ |\ |\
binding, blood flow to the tissues, ability of the drug to exit the
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
vascular space, and the ability of the drug to enter the cell
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
What do most drugs bind with - CORRECT ANSWERS ✔✔plasma
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
protein - albumin|\ |\
What does plasma protein albumin do after binding w drugs -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔acts as a carrier
|\ |\ |\ |\ |\
Bound drug molecules are considered - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\
✔✔inactive
Unbound/Free drug molecules are considered - CORRECT
|\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔active |\
What portion of the drug acts on body cells - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔the free or unbound portion
|\ |\ |\ |\ |\
, If a drug molecules is bound to plasma protein, why is it
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
considered inactive? - CORRECT ANSWERS ✔✔It is too big to |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
cross over into the tissues from the plasma
|\ |\ |\ |\ |\ |\ |\
In order for drugs to cross the Blood Brain Barrier they must be: -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Un-ionized, small molecules, and lipid
|\ |\ |\ |\ |\ |\ |\ |\
soluable
in order for drugs to pass the placental barrier they must be: -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Lipid soluable, smaller molecule drugs,
|\ |\ |\ |\ |\ |\ |\
and there must be passive diffusion
|\ |\ |\ |\ |\
Metabolism - CORRECT ANSWERS ✔✔the process of chemically |\ |\ |\ |\ |\ |\ |\ |\
changing a drug to a different compound called a metabolite
|\ |\ |\ |\ |\ |\ |\ |\ |\
What are active drugs changed into in order to be excreted? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔one or more inactive metabolites |\ |\ |\ |\ |\ |\
A function of Metabolism: - CORRECT ANSWERS ✔✔Changing
|\ |\ |\ |\ |\ |\ |\ |\
from an active metabolite to an inactive metabolite OR changing
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
from an inactive metabolite to an active metabolite.
|\ |\ |\ |\ |\ |\ |\
If a drug is administered as an inactive pro-drug what must
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
happen for the drug to have an effect? - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔The drug must be metabolized to an active metabolite from
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
the inactive pro-drug state to have an effect
|\ |\ |\ |\ |\ |\ |\
