CARDIOVASCULAR DRUGS NOTES

CARDIOVASCULAR DRUGS
NOTES BY ELIASPARAMEDIC.

1.ANTI-HYPERTENSIVE AGENTS
2. DRUGS USED IN HEART FAILURE
3. ANTI-ANGINA DRUGS
4. DRUGS USED IN DYSLIPIDEMIA
5. DRUGS FOR ARRHYTHMIAS




1

, ANTIHYPERTENSIVES
a) Angiotensin Converting Enzyme (ACE) inhibitors
e.g. Enalapril, captopril, lisinopril, ramipril.
Mxn: inhibit conversion of angiotensin I to
angiotensin II.
Adm: all administered per oral.
Effects:
i) reduce peripheral vascular resistance
ii) reduce circulating blood volume.
S/E: hypotension, acute renal failure,
hyperkalemia, dry cough, allergic skin rashes.
C/I: Renal failure; pregnancy (teratogenic)
10/22/2025 compiled by PMM 2

,b).Angiotensin II Receptor Blockers (ARBs)
Adm: all administered per oral.
e.g. Losartan, valsartan, telmisartan
Mxn: bind and block angiotensin II receptor.
S/E, C/I and effects are same as in ACE
inhibitors.




10/22/2025 compiled by PMM 3

, c) Calcium channel blockers
E.g. amlodipine, nifedipine, felodipine,
verapamil, diltiazem.
Adm: per oral.
Mxn: inhibit influx of calcium into arterial
smooth muscle cells hence reducing contraction.
Effect: reduce peripheral vascular resistance.
S/E: hypotension, palpitation, perspiration,
dizziness, headache, GIT disturbance.
C/I: cardiogenic shock, hypotension, pregnancy
(except nifedipine)
10/22/2025 compiled by PMM 4