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Defends against antigens
Destroys abnormal or damaged cells - answer ✔✔-Immune system functions
Excessive: hyper-functioning (autoimmunity, hyper sensitivity)
Deficient: ineffective response - answer ✔✔-types of immune alterations
Immune system attacks itself
Causes: abnormal response to MHC genes (HLA)
*higher risk in females
Treatment: immunosuppressive therapy (corticosteroids, cytotoxins) - answer ✔✔-Autoimmunity
type I → immediate, IgE- mediated, Allergic/Atopic/Anaphylactic,
type II → Cytotoxic (antibody-mediated), blood transfusion reactions
type III → Immune complex-mediated (lupus)
type IV → Delayed ("ACID"), contact dermatitis - answer ✔✔-Hypersensitivity types
IgE blockers
Epinephrine
Antihistamines
Beta-adrenergics (reduce broncoconstriction) - answer ✔✔-Treatment for type I hypersensitivity
Acute myeloid leukemia (AML)
Chronic Myeloid leukemia (CML)