PATHO 370 - WEEK 2 ADVANCED EXAM
QUESTIONS WITH COMPLETE VERIFIED
CORRECT SOLUTIONS
What is type I hypersensitivity and antigen form? - answer ✔✔-IgE and soluble antigen
What is type II hypersensitivity? - answer ✔✔-IgG OR IgM and cell-bound antigen
What is type III hypersensitivity? - answer ✔✔-IgG AND IgM and soluble antigen
What is type IV hypersensitvity? - answer ✔✔-T Cells and soluble or cell-bound antigen
What is type I hypersensitivity mechanism of activation? - answer ✔✔--Allergen-specific IgE antibodies
bind to mast cells via their Fc receptor.
-When the specific allergen binds to the IgE, cross-linking of IgE induces degranulation of mast cells.
What is type II hypersensitivity mechanism of activation? - answer ✔✔--IgG or IgM antibody binds to
cellular antigen, leading to complement activation and cell lysis.
-IgG can also mediate ADCC with cytotoxic T cells, natural killer cells, macrophages and neutrophils.
What is type III hypersensitivity mechanism of activation? - answer ✔✔-- Antigen-antibody complexes
are deposited on tissues.
- Complement activation provides inflammatory mediators and recruits neutrophils.
,-Enzymes released neutrophils damage tissue.
What is type IV hypersensitivity mechanism of activation? - answer ✔✔-- TH1 cells secrete cytokines,
which activate macrophages and cytotoxic T cells.
What is a type I hypersensitivity reaction? - answer ✔✔-- Local and systemic anaphylaxis
-Seasonal hay fever
- Food allergies
- Drug allergies
What is a type II hypersensitivity reaction? - answer ✔✔-- RBC destruction after transfusion with
mismatched blood types during hemolytic disease of the newborn
What is a type III hypersensitivity reaction? - answer ✔✔-- Post-streptococcal glomerulonephritis
-Rheumatoid arthritis
-Systemic lupus erythematosus
What is a type IV hypersensitivity reaction? - answer ✔✔-- Contact dermatitis
-Type I diabetes mellitus
-Multiple sclerosis
(slowest)
, What is excessive immune response? - answer ✔✔-A type of alteration in immune function: over or
hyper-function of immune system
What is deficient immune response? - answer ✔✔-A type of alteration in immune function: ineffective
immune response
What is autoimmunity? - answer ✔✔-Immune system attacks own tissues
What is the cause of autoimmunity? - answer ✔✔-Abnormal excessive immune responses toward own
tissues.
What is the MHC gene? (HLA) - answer ✔✔-Appear to increase risk of autoimmune disorders
females at higher risk
What is hypersensitivity? - answer ✔✔--Describes the mechanism of injury
-May or may not involve autoimmunity
What is the treatment of autoimmunity? - answer ✔✔-Individualized immunosuppressive therapy -
1. Corticosteroids and cytotoxins (MTX)
2. Tumor necrosis factor inhibitors and
immunomodulators - (Monoclobal Antibodies (MAB))
3. Therapeutic plasmapheresis
What is the mechanism of treatment for type I hypersensitivity of IgE blocker therapy? - answer ✔✔-
Inhibits binding of IgE to mast cells (Only for Type I)
QUESTIONS WITH COMPLETE VERIFIED
CORRECT SOLUTIONS
What is type I hypersensitivity and antigen form? - answer ✔✔-IgE and soluble antigen
What is type II hypersensitivity? - answer ✔✔-IgG OR IgM and cell-bound antigen
What is type III hypersensitivity? - answer ✔✔-IgG AND IgM and soluble antigen
What is type IV hypersensitvity? - answer ✔✔-T Cells and soluble or cell-bound antigen
What is type I hypersensitivity mechanism of activation? - answer ✔✔--Allergen-specific IgE antibodies
bind to mast cells via their Fc receptor.
-When the specific allergen binds to the IgE, cross-linking of IgE induces degranulation of mast cells.
What is type II hypersensitivity mechanism of activation? - answer ✔✔--IgG or IgM antibody binds to
cellular antigen, leading to complement activation and cell lysis.
-IgG can also mediate ADCC with cytotoxic T cells, natural killer cells, macrophages and neutrophils.
What is type III hypersensitivity mechanism of activation? - answer ✔✔-- Antigen-antibody complexes
are deposited on tissues.
- Complement activation provides inflammatory mediators and recruits neutrophils.
,-Enzymes released neutrophils damage tissue.
What is type IV hypersensitivity mechanism of activation? - answer ✔✔-- TH1 cells secrete cytokines,
which activate macrophages and cytotoxic T cells.
What is a type I hypersensitivity reaction? - answer ✔✔-- Local and systemic anaphylaxis
-Seasonal hay fever
- Food allergies
- Drug allergies
What is a type II hypersensitivity reaction? - answer ✔✔-- RBC destruction after transfusion with
mismatched blood types during hemolytic disease of the newborn
What is a type III hypersensitivity reaction? - answer ✔✔-- Post-streptococcal glomerulonephritis
-Rheumatoid arthritis
-Systemic lupus erythematosus
What is a type IV hypersensitivity reaction? - answer ✔✔-- Contact dermatitis
-Type I diabetes mellitus
-Multiple sclerosis
(slowest)
, What is excessive immune response? - answer ✔✔-A type of alteration in immune function: over or
hyper-function of immune system
What is deficient immune response? - answer ✔✔-A type of alteration in immune function: ineffective
immune response
What is autoimmunity? - answer ✔✔-Immune system attacks own tissues
What is the cause of autoimmunity? - answer ✔✔-Abnormal excessive immune responses toward own
tissues.
What is the MHC gene? (HLA) - answer ✔✔-Appear to increase risk of autoimmune disorders
females at higher risk
What is hypersensitivity? - answer ✔✔--Describes the mechanism of injury
-May or may not involve autoimmunity
What is the treatment of autoimmunity? - answer ✔✔-Individualized immunosuppressive therapy -
1. Corticosteroids and cytotoxins (MTX)
2. Tumor necrosis factor inhibitors and
immunomodulators - (Monoclobal Antibodies (MAB))
3. Therapeutic plasmapheresis
What is the mechanism of treatment for type I hypersensitivity of IgE blocker therapy? - answer ✔✔-
Inhibits binding of IgE to mast cells (Only for Type I)
