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v 6th EDITION v
1. Which of the following is a condition that can be described as irreversible pathosis of
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vthe pulp:
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a. Dentin hypersensitivity
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b. Pulp canal obliteration (total calcification)
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c. Internal resorption v
d. Sharp, brief pain with thermal changes
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2. The following inflammatory mediator(s) is/are not elevated in the pulp, in cases with
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vsymptomatic irreversible pulpitis: v v
a. Prostaglandins
b. Leukotrienes
c. Bradykinin
d. Neuropeptides
e. Matrix metalloproteinases
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vExplain:
● Symptomatic irreversible pulpitis is a condition where the pulp tissue in the
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v tooth is inflamed and cannot heal, resulting in persistent pain and sensitivity.
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v Several inflammatory mediators are involved in this process, including
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v prostaglandins (option a), bradykinin (option c), neuropeptides (option d), and
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v matrix metalloproteinases (option e). These mediators can cause pain,
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v swelling, and tissue damage. v v v
● Leukotrienes are lipid mediators involved in the inflammatory response, but
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v they are not typically elevated in cases of symptomatic irreversible pulpitis.
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v Instead, they are more commonly associated with other inflammatory
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v conditions, such as asthma and allergies.
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3. The following cytokine acts to control the expansion of periapical lesions:
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a. IL-1
b. IL-8
c. IL-10
d. TNF-alpha
e. IL-17