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1. Although his ability to speak is otherwise normal, a Use functional magnetic
patient suffering from a stroke is having difficulty resonance imaging (fMRI)
naming common objects, such as tools. In order to to compare the activity
determine which region of the brain is functioning of the brains of the pa-
abnormally, which non-invasive technique would be tient and normal volun-
the most useful approach for his doctor to use for lo- teers when they name
calizing the impaired functional region and providing tools
a diagnosis?
During neurosurgery on the patient, electrically stim-
ulate his entire brain until tools are named
Do a computed tomography (CT) scan on the brain to
look for skull injuries
During neurosurgery on the patient, perform an ab-
lation procedure to remove a portion of the temporal
lobe
Use functional magnetic resonance imaging (fMRI) to
compare the activity of the brains of the patient and
normal volunteers when they name tools
2. Which set of electrical recording methodologies is cor- patch clamp, single unit,
rectly ordered from smallest recording area to largest multi-unit, local field po-
recording area (scale)? tential (LFP), electroen-
cephalograph (EEG)
local field potential (LFP), patch clamp, multi-unit, sin-
gle unit, electroencephalograph (EEG)
electroencephalograph (EEG), local field potential
(LFP), multi-unit, single unit, patch clamp
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multi-unit, local field potential (LFP),
electroencephalograph (EEG), single unit, patch
clamp
single unit, electroencephalograph (EEG), multi-unit,
patch clamp, local field potential (LFP)
patch clamp, single unit, multi-unit, local field poten-
tial (LFP), electroencephalograph (EEG)
3. Which investigative question would be BEST answered How does the pattern of
by local field potential (LFP) recording techniques? electrical activity in one
small area compare to a
What is the whole-brain pattern of electrical activity? different small area?
How does the pattern of electrical activity in one small
area compare to a different small area?
When do ion channels open on an individual neuron?
When does an individual neuron fire action poten-
tials?
How does whole-brain electrical activity respond to a
stimulus over repeated, averaged trials?
4. What is one of the BIGGEST limitation or disadvantage Compared to other tech-
of using electroencephalography (EEG) niques, it has limited spa-
tial resolution so it is diffi-
Compared to other techniques, it has limited spatial cult to identify where sig-
resolution so it is difficult to identify where signals are nals are coming from
coming from
Compared to other techniques, it can only be used on
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healthy neurotypical individuals
Compared to other techniques, it has limited temporal
resolution so it is difficult to identify when signals are
happening
Compared to other techniques, it is very invasive and
risky for participants
Compared to other techniques, it is very expensive
and costly to obtain and run
5. Ken is volunteering to be a subject in medical re- electrocorticogram
search, but he is prone to infection and would like (ECoG)
to avoid any highly invasive procedures. Which of the
following methods is the MOST invasive and risky for
Ken?
electroencephalogram (EEG)
magnetoencephalogram (MEG)
electrocorticogram (ECoG)
transcranial magnetic stimulation (TMS)
diffusion tensor imaging (DTI)
6. Michael fractured his arm and had to have screws Computed Tomography
inserted while it heals. Assume the screws are made (CT) Scan
of a magnetic metal and could be pulled out by ex-
posure to a strong magnet. Which imaging technique
would NOT involve exposure to a strong magnet and
therefore would be the SAFEST for Michael?
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Computed Tomography (CT) Scan
No choice options would be safe because they all in-
volve the use of a strong magnet
Diffusion Tensor Imaging (DTI)
functional Magnetic Resonance Imaging (fMRI)
Magnetic Resonance Imaging (MRI)
7. Which of the following statements about research Research on animals does
with animal models is FALSE? not require any institu-
tional oversight
The smallest number of animal subjects should be
used
Experimental methodology should be modified to re-
duce animal harm or distress
When possible research questions should be an-
swered without the use of animals
All choice options are TRUE statements
Research on animals does not require any institution-
al oversight
8. A brain area that is posterior and dorsal to another Caudal; superior
brain structure could also be described as _______ and
_______ to that structure
Caudal; inferior