– Complete Study Guide & Practice Questions”
Climacteric phase - ---✔✔✔ANSWER----The period of endrocrinologic,
somatic, and transitory psychologic changes that occur around the time of
menopause.
Early menopause - ---✔✔✔ANSWER----LMP before age 45
Late menopause - ---✔✔✔ANSWER----LMP after age 54
Primary ovarian insufficiency - ---✔✔✔ANSWER----Menopause that
occurs before age 40
Early menopause transition (stage -2) - ---✔✔✔ANSWER----Persistent
difference of 7 days or more in the length of consecutive cycles.
,Late menopause transition (stage -1) - ---✔✔✔ANSWER----60 or more
consecutive days of amenorrhea
Luteal out of phase event (LOOP) - ---✔✔✔ANSWER----Explains why
some perimenopausal women have elevated estrogen level sometimes...In the early
menopause transition, elevated FSH levels are adequate to recruit a second follicle
which results in a follicular phase-like rise in estradiol secretion superimposed on
the mid-to-late luteal phase of the ongoing ovulatory cycle.
Obese women and estradiol levels during menopause - ---✔✔✔ANSWER---
-Obese women are more likely to have anovulatory cycles with high estradiol
levels. They are also more likely to have lower premenopause yet higher
postmenopause estradiol levels compared with women of normal weight. (why
they are at higher risk of endometrial cancer)
Chinese and Japanese women - ---✔✔✔ANSWER----These ethnic groups
have lower estradiol levels then white, black and hispanic women.
stage +2 - ---✔✔✔ANSWER----late menopause stage: 5-8 years after FMP.
Somatic aging predominates. Increased genitourinary symptoms.
Stages +1a, +1b, +1c - ---✔✔✔ANSWER----early post menopause: 2 years
after FMP. FSH rises, estradiol decreases. VMS predominate.
Elevated FSH, LH - ---✔✔✔ANSWER----Endocrine labs after menopause
, AMH, inhibin B - ---✔✔✔ANSWER----These hormones work during
reproductive years to not deplete follicle pool too quickly.
Phases during menopause transition and PMS symptoms - ---
✔✔✔ANSWER----Menstrual cycle shortenes, follicular phase compresses,
women spend more time in luteal phase.. meaning more premenstrual symptoms
and more frequent menstrual periods.
How to respond if a patient requests FSH lab? - ---✔✔✔ANSWER----many
pitfalls, variable depending on the day of the cycle you draw the lab, normal or low
FSH is not helpful.
The potentially superior marker of menopause, a lab. - ---✔✔✔ANSWER---
-AMH
DHEA (dehydroepiandrosterone) - ---✔✔✔ANSWER----Adrenal
androgens: precursor hromones produced by the adrenal gland that are
enzymatically converted to active androgens or estrogens in peripheral tissues.
Location of estrogen receptors - ---✔✔✔ANSWER----Vagina, vulva,
urethra, trigone of the bladder