NAPLEX: Kidney Disease UPDATED
ACTUAL QUESTIONS AND CORRECT
ANSWERS
how does ADH work on the kidneys? - Correct answers✔✔stimulates aquaporins in DT/CD
how does ADH affect blood vessels? - Correct answers✔✔vasoconstriction
which is a stronger diuretic? thiazide or loop? - Correct answers✔✔loop
T/F: thiazides protect bone - Correct answers✔✔true
what are 2 ways to assess severity of kidney disease? - Correct answers✔✔albumin in urine and
GFR
what 2 laboratory markers are used to estimate kidney function? - Correct answers✔✔BUN and
SCr
which drugs can cause kidney disease? - Correct answers✔✔aminoglycosides, amphotericin B,
cyclosporine, tacrolimus, colistimethate, NSAIDs, radiographic contrast dye, vancomycin, loop
diuretics, cisplatin, SGLT2 inhibitors
what does BUN measure? - Correct answers✔✔amount of nitrogen that comes from urea, a
waste product of protein metabolism
what are causes of elevated BUN? - Correct answers✔✔prerenal: high protein diet, dehydration
, renal: CKD, AKI
postrenal: kidney stones, enlarged prostate
what is the normal SCr? - Correct answers✔✔0.6 - 1.3 mg/dL
what does SCr measure? - Correct answers✔✔serum creatinine, waste product of muscle
metabolism
CrCl is usually over/under-estimated for frail, elderly with low muscle mass? - Correct
answers✔✔overestimated b/c low muscle mass = low SCr
CrCl is usually over/under-estimated for pregnant women? - Correct answers✔✔GFR increases
in pregnant women so SCr is low = overestimate
under which states is CrCl inaccurate? - Correct answers✔✔obesity, liver disease, pregnancy,
high muscle mass,
when is CrCl not preferred? - Correct answers✔✔young children, ESRD, unstable renal function
which drugs are dosed based on GFR? - Correct answers✔✔SGLT2 and metformin
T/F? proteinuria = albuminuria - Correct answers✔✔true
which 2 guidelines do we use for CKD? - Correct answers✔✔KDIGO, KDOQI
normal ACR (albumin/creatinine ratio) - Correct answers✔✔<30
ACTUAL QUESTIONS AND CORRECT
ANSWERS
how does ADH work on the kidneys? - Correct answers✔✔stimulates aquaporins in DT/CD
how does ADH affect blood vessels? - Correct answers✔✔vasoconstriction
which is a stronger diuretic? thiazide or loop? - Correct answers✔✔loop
T/F: thiazides protect bone - Correct answers✔✔true
what are 2 ways to assess severity of kidney disease? - Correct answers✔✔albumin in urine and
GFR
what 2 laboratory markers are used to estimate kidney function? - Correct answers✔✔BUN and
SCr
which drugs can cause kidney disease? - Correct answers✔✔aminoglycosides, amphotericin B,
cyclosporine, tacrolimus, colistimethate, NSAIDs, radiographic contrast dye, vancomycin, loop
diuretics, cisplatin, SGLT2 inhibitors
what does BUN measure? - Correct answers✔✔amount of nitrogen that comes from urea, a
waste product of protein metabolism
what are causes of elevated BUN? - Correct answers✔✔prerenal: high protein diet, dehydration
, renal: CKD, AKI
postrenal: kidney stones, enlarged prostate
what is the normal SCr? - Correct answers✔✔0.6 - 1.3 mg/dL
what does SCr measure? - Correct answers✔✔serum creatinine, waste product of muscle
metabolism
CrCl is usually over/under-estimated for frail, elderly with low muscle mass? - Correct
answers✔✔overestimated b/c low muscle mass = low SCr
CrCl is usually over/under-estimated for pregnant women? - Correct answers✔✔GFR increases
in pregnant women so SCr is low = overestimate
under which states is CrCl inaccurate? - Correct answers✔✔obesity, liver disease, pregnancy,
high muscle mass,
when is CrCl not preferred? - Correct answers✔✔young children, ESRD, unstable renal function
which drugs are dosed based on GFR? - Correct answers✔✔SGLT2 and metformin
T/F? proteinuria = albuminuria - Correct answers✔✔true
which 2 guidelines do we use for CKD? - Correct answers✔✔KDIGO, KDOQI
normal ACR (albumin/creatinine ratio) - Correct answers✔✔<30
