MAT waiver 8 hour training verified questions and answers 2025/ 2026
edition
Terms in this set (12)
What does it mean when you say It will displace the full mu receptor agonist like heroin and methadone.
buprenorphine has a strong
affinity?
It stays on receptor for a long time and blocks heroin or other
How does Buprenorphine work? opioids from binding to that receptor. This is called dissipate
where the speed of disengaging off a
receptor is slow.
- with short acting opioids like heroine and oxycodone, begins in 6-
What is spontaneous withdrawal? 12 hours after last dose and peaks 36-72 hours.
- it last about 5 days
What is spontaneous Begin 36-72 hours after last dose with longer period before peak is reached.
withdrawal with opioids with
longer half lives such as
methadone?
Activates opioid receptor in brain and blocks effect of heroin and
How does methadone work in
OUD? causes less cravings
Partial activation of opioid receptor thus decreasing drug use and
How does buprenorphine work in
OUD? protect from overdose.
What drug can be used in OUD Naltrexone
once taper off buprenorphine?
Antagonist opioid
How does Naltrexone work in - must be off opioids 7 days and is normally used after detox to
OUR? prevent relapse. Monthly injection or oral 30 days
- it is secondary to derangement of endogenous opioid receptor.
What is protracted Abstinence
Syndrome? The s/s are: malaise, fatigue, insomnia, poor tolerance, opioid
cravings
Which drug has high binding and Naltrexone
affinity out of 3 drugs?
edition
Terms in this set (12)
What does it mean when you say It will displace the full mu receptor agonist like heroin and methadone.
buprenorphine has a strong
affinity?
It stays on receptor for a long time and blocks heroin or other
How does Buprenorphine work? opioids from binding to that receptor. This is called dissipate
where the speed of disengaging off a
receptor is slow.
- with short acting opioids like heroine and oxycodone, begins in 6-
What is spontaneous withdrawal? 12 hours after last dose and peaks 36-72 hours.
- it last about 5 days
What is spontaneous Begin 36-72 hours after last dose with longer period before peak is reached.
withdrawal with opioids with
longer half lives such as
methadone?
Activates opioid receptor in brain and blocks effect of heroin and
How does methadone work in
OUD? causes less cravings
Partial activation of opioid receptor thus decreasing drug use and
How does buprenorphine work in
OUD? protect from overdose.
What drug can be used in OUD Naltrexone
once taper off buprenorphine?
Antagonist opioid
How does Naltrexone work in - must be off opioids 7 days and is normally used after detox to
OUR? prevent relapse. Monthly injection or oral 30 days
- it is secondary to derangement of endogenous opioid receptor.
What is protracted Abstinence
Syndrome? The s/s are: malaise, fatigue, insomnia, poor tolerance, opioid
cravings
Which drug has high binding and Naltrexone
affinity out of 3 drugs?
