UAMS Biochemistry Exam 5
Study online at https://quizlet.com/_9pu7mk
1. Xenobiotics Chemicals and drugs not normally found or produced in the body
2. What are the Ingestion, inhalation and transdermal exposure
most common
routes of expo-
sure?
3. What are the Blood and urine
typical toxicology
specimens?
4. What is the two 1. Screening test - rapid, qualitative
step procedure in -methods- screening cards, immunoassays
toxicology? 2. Confirmation- Confirms screening results
-methods- TLC, gas chromotography, ICP-MS, AA
5. What are the gen- Disorientation, confusion, euphoria
eral toxic effects?
6. Ethanol Associated with abusive alcoholic consumption
-BAC of 80mg/dL (0.08%) = statute limit
7. Methanol -Typically accidental ingestion
-Can cause severe acidosis, leading to death or blindness
8. Isopropanol Severe acute-phase ethanol-like symptoms
9. Ethylene glycol -Antifreeze
-Severe metabolic acidosis, renal tubular damage
10. Carbon monox- -Gas, fire, improperly vented furances, wood/plastic fires
ide -Colorless, odorless, tasteless
11. Leads to pulmonary edema, shock and death
1/6
, UAMS Biochemistry Exam 5
Study online at https://quizlet.com/_9pu7mk
Aspiration of
caustic agents
12. Ingestion of -Lesions in esophagus and GI tract
caustic agents
13. Cyanide -Expresses toxicity by binding to heme iron
-Increases O2 tension and venous PO2
14. Arsenic -Typically only detectable for a few hours in the blood
15. Cadmium -Typically accumulates in the kidney where the toxic effects are expressed
16. Pesticides -Chronic and acute disease states, death
-Organophosphates, carbamates, halogenated hydrocarbons
17. Salicylates -Decreased thromboxane and prostagladin formation
-Metabolic acidosis and possible death
18. Acetaminophen -Overdose associated with severe hepatotoxicity
-Quantify with immunoassay or HPLC
19. What is the Immunoassay, Thin-layer chromatography, liquid and gas chromatography
methodology for
drugs of abuse?
20. What are the -Amphetamines(for narcolepsy and attention deficit disorder)
drugs of abuse? -Methamphetamines
-Opioids
-Fentanyl
-THC
-Cocaine
-PCP
2/6
Study online at https://quizlet.com/_9pu7mk
1. Xenobiotics Chemicals and drugs not normally found or produced in the body
2. What are the Ingestion, inhalation and transdermal exposure
most common
routes of expo-
sure?
3. What are the Blood and urine
typical toxicology
specimens?
4. What is the two 1. Screening test - rapid, qualitative
step procedure in -methods- screening cards, immunoassays
toxicology? 2. Confirmation- Confirms screening results
-methods- TLC, gas chromotography, ICP-MS, AA
5. What are the gen- Disorientation, confusion, euphoria
eral toxic effects?
6. Ethanol Associated with abusive alcoholic consumption
-BAC of 80mg/dL (0.08%) = statute limit
7. Methanol -Typically accidental ingestion
-Can cause severe acidosis, leading to death or blindness
8. Isopropanol Severe acute-phase ethanol-like symptoms
9. Ethylene glycol -Antifreeze
-Severe metabolic acidosis, renal tubular damage
10. Carbon monox- -Gas, fire, improperly vented furances, wood/plastic fires
ide -Colorless, odorless, tasteless
11. Leads to pulmonary edema, shock and death
1/6
, UAMS Biochemistry Exam 5
Study online at https://quizlet.com/_9pu7mk
Aspiration of
caustic agents
12. Ingestion of -Lesions in esophagus and GI tract
caustic agents
13. Cyanide -Expresses toxicity by binding to heme iron
-Increases O2 tension and venous PO2
14. Arsenic -Typically only detectable for a few hours in the blood
15. Cadmium -Typically accumulates in the kidney where the toxic effects are expressed
16. Pesticides -Chronic and acute disease states, death
-Organophosphates, carbamates, halogenated hydrocarbons
17. Salicylates -Decreased thromboxane and prostagladin formation
-Metabolic acidosis and possible death
18. Acetaminophen -Overdose associated with severe hepatotoxicity
-Quantify with immunoassay or HPLC
19. What is the Immunoassay, Thin-layer chromatography, liquid and gas chromatography
methodology for
drugs of abuse?
20. What are the -Amphetamines(for narcolepsy and attention deficit disorder)
drugs of abuse? -Methamphetamines
-Opioids
-Fentanyl
-THC
-Cocaine
-PCP
2/6
