Chamberlain NR507 Midterm Exam Questions & Answers | 100%
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Terms in this set (63)
- "Allergic reaction"
- Mediated by IgE.
- Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
Type 1 Hypersensitivity
- Local s/s: itching, rash.
Reaction
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension, severe
bronchoconstriction.
- Main tx: epinephrine.
- Cytotoxic reaction; tissue specific
- Macrophages are the primary effectors cells involved
- Causes tissue damage or alters function
- Examples: 1) Grave's disease- example of altering thyroid
Type 2 Hypersensitivity
Reaction function, doesn't destroy thyroid tissue. 2) ABO
incompatibility- example of cell/tissue damage; severe
transfusion reaction occurs & the transfused erythrocytes
are destroyed by agglutination or complement-mediated
lysis.
- Type 2: organ specific; antibody binds to the antigen on the cell
Difference between type 2 & 3 surface.
- Type 3: not organ specific; antibody binds to soluble
hypersensitivity reactions
antigen outside the cell surface that was released into the
blood or body fluids, and the complex is then deposited in
the tissues.
, - Immune complex
- Antigen-antibody complex deposited in the tissues
Type 3 Hypersensitivity - Neutrophils are the primary effector cell
Reaction - Causes autoimmune diseases
- Examples: rheumatoid arthritis ( joints), systemic lupus
erythematosus (SLE, organs)
- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia,
leukopenia, lymphopenia, thrombocytopenia)
Systemic Lupus Erythematosus - Immunologic disorders
(SLE) - Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
- Can be familial: Affected family members may not all develop
Autoimmunity the same disease, but several members may have different
disorders characterized by a variety of hypersensitivity
reactions (autoimmune and allergic reactions).
- General term used to describe when an individual's immune
system reacts against antigens on the tissues of other
Alloimmunity members of the same species.
- Examples: Neonatal disease where the maternal immune
system becomes sensitized against antigens expressed by the
fetus, Transplant rejection, Transfusion reaction.
- T-cell mediated
- Lymphocytes
- Does not involve antigen/antibody complexes
Type 4 Hypersensitivity
- Delayed response
Reaction
- Ex: localized contact dermatitis. Treated with a topical
corticosteroid (wouldn't use antihistamine since Type 4
doesn't involve mast cells and H1 receptors).
- Type 1: Immediate hypersensitivity reactions, termed atopic
dermatitis, are usually characterized by widely distributed
lesions.
Differentiating between the rash - Type 4: Contact dermatitis (delayed hypersensitivity)
of a Type 1 vs Type 4 Reaction consists of lesions only at the site of contact with the
Verified solutions |Questions with Correct Answers 2025 latest
update!!
Terms in this set (63)
- "Allergic reaction"
- Mediated by IgE.
- Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
Type 1 Hypersensitivity
- Local s/s: itching, rash.
Reaction
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension, severe
bronchoconstriction.
- Main tx: epinephrine.
- Cytotoxic reaction; tissue specific
- Macrophages are the primary effectors cells involved
- Causes tissue damage or alters function
- Examples: 1) Grave's disease- example of altering thyroid
Type 2 Hypersensitivity
Reaction function, doesn't destroy thyroid tissue. 2) ABO
incompatibility- example of cell/tissue damage; severe
transfusion reaction occurs & the transfused erythrocytes
are destroyed by agglutination or complement-mediated
lysis.
- Type 2: organ specific; antibody binds to the antigen on the cell
Difference between type 2 & 3 surface.
- Type 3: not organ specific; antibody binds to soluble
hypersensitivity reactions
antigen outside the cell surface that was released into the
blood or body fluids, and the complex is then deposited in
the tissues.
, - Immune complex
- Antigen-antibody complex deposited in the tissues
Type 3 Hypersensitivity - Neutrophils are the primary effector cell
Reaction - Causes autoimmune diseases
- Examples: rheumatoid arthritis ( joints), systemic lupus
erythematosus (SLE, organs)
- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia,
leukopenia, lymphopenia, thrombocytopenia)
Systemic Lupus Erythematosus - Immunologic disorders
(SLE) - Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
- Can be familial: Affected family members may not all develop
Autoimmunity the same disease, but several members may have different
disorders characterized by a variety of hypersensitivity
reactions (autoimmune and allergic reactions).
- General term used to describe when an individual's immune
system reacts against antigens on the tissues of other
Alloimmunity members of the same species.
- Examples: Neonatal disease where the maternal immune
system becomes sensitized against antigens expressed by the
fetus, Transplant rejection, Transfusion reaction.
- T-cell mediated
- Lymphocytes
- Does not involve antigen/antibody complexes
Type 4 Hypersensitivity
- Delayed response
Reaction
- Ex: localized contact dermatitis. Treated with a topical
corticosteroid (wouldn't use antihistamine since Type 4
doesn't involve mast cells and H1 receptors).
- Type 1: Immediate hypersensitivity reactions, termed atopic
dermatitis, are usually characterized by widely distributed
lesions.
Differentiating between the rash - Type 4: Contact dermatitis (delayed hypersensitivity)
of a Type 1 vs Type 4 Reaction consists of lesions only at the site of contact with the
