antiseptics Antibiomimetic Antibiotic Past-antibiotic diterpenic antibiotic natural polypeptide antiob
hydrogen peroxide sulphonamide fluroquenolone Nitrofurans cephalosporine aminoglycoside Pleuromutilin polymyxins
Dihydrostrepto
potassium permanganate sulphamerazine Enrofloxacin nitrufural cephalexin mycin sulphate Tiamulin fumarate Colistin
cephapirin Valnemulin
ethanol sulphadimidine Flumequine nitrufurantion sodium Gentamicin HYDROCHLORIDE Glycopeptides
ceftiofur
,chloramine B, SULFADIAZINE Methenamine sodium Spectinomycin ansamicines
cefovecin
iodine, SULFAMETHOXAZOLE sodium tetracyclines Rifaximin
cefquinome
,chlorhexidine, SULFADIMETHOXINE sulphate Oxytetracycline Past-antibiotic
cationic detergent, SULFACHLORPYRIDAZINE benzylpenicillin procaine salt Doxycycline lincosamides
Ichthammol Trimethoprim phenoxymethylpenicillin Amphenicols Lincomycin
birch tar NAFCILLIN SODIUM Thiamphenicol
CLOXACILLIN SODIUM Florfenicol
AMPICILLIN macrolides
amoxicillin Erythromycin
tulathromycin
tylosin
tylvalosin
, Use for Mechanism of action characteristic Side effect Abso
Hydrogen 3% :local haemostatic,washing wounds,skin peroxidise and catalase decompose,release atomic(from short,weak, poorly -not use for major blood vesseles bec
peroxide 0.3-0.5%:mastitis ,gingivitis (mouth cavity) peroxidase,kill microorganism) and molecular(catalase penetrate make embolism
-As a disinfectant in water treatment and food processing facilities and for sterilization of dental and decompose,formed bubble) oxigen.
surgical instruments. -as a local haemostatic :exposed to the oxygen
fibrinogen quickly turns into fibrin (activates prothrombin)
-against bacteria, spores alittle, mycobacteria, viruses, and fungi. stop bleeding.
potassium 0.01%-0.1%:washing wounds,mouth cavity,stomach intoxication atomic oxigen is formed manganese oxide, which
permangenate 0.01%:algicide reacts with the tissue proteins to form an
1%:virucide albuminates. Therefore, irritats and causticum
alcohols skin.they do not destroy bacterial spores. affect most of enveloped viruses and fungi.efficiency damages bacterial membranes and walls and their Alcohols dry out the skin and can cause local
decreases significantly if the tissues are covered with the excreta, mucus or blood. THE SAFEST ability to coagulate cytoplasmic proteins. inflammation.
ANTISPTIC;
ethanol -Bactericidal is 70 %.in general used in concentrations of 30–90% in aqueous. Ethanol accumulate in the fatty -if it contact with skin or mucous membrane: In the
-In herbivores:improves the secretion of digestive glands, increases digestion, improves motility, reduces tissue, but also in muscle and 2‒3 % ethanol solution causes hyperemia, is elim
fermentation of the stomach or rumen (tympany), in intestinal atony and colics. parenchymal organs. increased glandular secretion. and If the excre
-intravenous:20-33% ethanol solution.normalises blood circulation, increases respiration, increases the body's concentration is high (70‒90 %), ethanol is partly
resistance. Low doses of ethanol, injected intravenously, the body temperature raises, in large doses ‒
reduces.higher than 40% necrosis.
strongly irritating, large amounts of mucus
-For horse , cattle, goat and sheep: sedation p.o. or i.v.; pain relief p.o. or i.v.; to improve digestion p.o.; fever excret, the mucous membrane may be even
reduction p.o.; necrotised.90-95% CNS dysfunction.
-pig ‒ to improve digestion ‒ p.o.; -subcutaneous administration of 40 % ethanol,
-dog ‒ to improve digestion, increase activity ‒ p.o. becomes strongly irritated, possibly even
inflammation occurs
chloramine B not irritate the tissue.has a spermicidal effect. 1.5‒ through formation of undissociated white or yellowish crystalline
2 % solutions are used for wounds, hypochlorous acid (HOCl) in water at acid to powder, with weak chlorine
0.25‒0.5 % solution washed hands or teats odor. 1:20 soluble in water, in
neutral pH. alcohol ‒ 1:25.
iodine -Iodine:Disinfect and prevent bleeding,Especially sensitive to iodine is Staphylococcus spp., E. coli and inhibits important enzymatic systems( interfere with vital . It is poorly soluble in water but -In serose cavities and cysts iodine causes - excr
Proteus spp. metabolic reactions), react with water and release the readily dissolves in ethanol. inflammation and the cavity obliteration. Especially amoun
-is well absorbed through the skin and mucous membranes active -The iodine compound with iodine irritates the mucous membranes bronch
-oral administration potassium iodide acts anti inflammatory as well as metabolic processes activating. oxidizing oxygen.therefor oxidize protein. polyvinyl alcohol does not
-2 % iodine, 6 % of potassium iodide used as an anti-inflammatory and resorption stimulating drug for udder, irritate the skin and mucous
joints, skin, muscle, tendon inflammation, blackleg, boils and treatment of pyoderma. membranes
-Ethanolic 5% iodine solution:
--potassium iodide is dissolved in 95 % ethanol and water is used in surgical practice for initial treatment of the
wound edges and to prepare the surgeon's hands.Slows wound healing. Not to be used externally for cats, as
it causes severe epidermal necrolysis.
--Iodine tincture contains 2% iodine and 2.4% sodium iodide (NaI) dissolved in 50% ethanol; it is used as a
skin disinfectant.
-POVIDONE IODINE . Iodophors. used as skin disinfectants, particularly before surgery and treatment of
wounds and burns. effective against bacteria, viruses, and fungi but less so against spores. Used Utersol .
uterine foam for cattle.and Betadine dermal solution.
--Phosphoric acid is often mixed with iodophors. used in teat dips to control mastitis.
chlorhexidine shampoo,skin,ointment,surgical,dental,wound cleansers, teat dips.. Used for dogs, cats disrupts the cytoplasmic membrane. is unaffected or enhanced by is decressed by high concentrations of organic
chlorhexidine can be toxic. alcohols, quaternary matter (pus, not blood, etc), hard water, and contact
-1% chlorhexidine acetate ointment:wounds cat,dog,horse ammonium compounds, and with cork. It is incompatible with anionic compounds,
- against most gram+ and some gram- bacteria but not against spores,not virus not fungi so much. alkaline pH. including soap.
A 0.1 % aqueous solution is bactericidal against Staphylococcus aureus, Escherichia coli, and
Pseudomonas aeruginosa
cationic not against nonenveloped viruses, mycobacteria, and spores.effective especially in alkaline ph. action from cell membrane.changes in permeability
good for surface not skin.
detergents
,ichthamol -When applied to the affected area shrinks blood vessels, inhibit secretion and exudation.For dark brown,black .Soluble in
external bleeding use 5‒10 % ichthammol solution swabs. water and glycerol..
-reduces pain,partly anesthesise -
anti-inflammatory,keratoplastic substance
-promotes tissue regeneration.
-10‒20 % ointment is used in skin diseases(dermatitis, scabies, dermatomycoses, furunculosis,
pyoderma,eczema), subcutaneous tissue and muscle diseases(cellulitis, myositis) , arthritis,
neuralgia, tendinitis, tendovaginitis,bursitis, mastitis,wounds, burns treatment.
-As fermentation stopping material is applied by mouth 2 % solution or as a bolus.
-Do not use in food-producing animals because for an ichthammol there is no established
MRLs
birch tar or -bandaging of wounds of the hoof and horn. as a keratoplastic tool ‒ in the hoof cracks ‒ 5‒10 % black oily, Containing
ointments, liniments or emulsions. phenol, cresol, guaiacol,
pine tar
-Enters in Wisniewski liniment composition used to treat wounds, ulcers,bed sores, burns and toluene, tar and others
others skin diseases.
-Externally used in chronic skin diseases (weeping dermatitis, eczema, itch).
-Pine tar contains phenol derivatives that provide antimicrobial properties. It has antibacterial,
antiparasitic, irritant, anti-inflammatory and low conc. (3‒5 %) keratoplastic effects.
-Orally can be applied 5 % aqueous emulsion in case of the rumen atony with tympania.
-For respiratory diseases to facilitate coughing can be used tar vapor inhalation.
-Do not use food-producing animals as MRL is not established.
skin disease Iodine 2%+potassium iodide 6%/ Iodine 2% + ethanol 50%+sodium iodide 2.4%/ iodophores/ stop bleeding:3%hydrogen peroxide-iodine- decrease fever:ethanol ,
Ichthamol 10-20%/ Birchtar wisniewski liniment ichthamol 5-10% herb,p.o
anti- iodine 2%+potassium iodide 6% mouth cavity:hydrogen peroxide 0.3-0.5% stomach intoxication: potassium
inflammatory permanganate 0.01-0.1 %
couthing inhalation Birchtar keratoplastic:ichthamol,Birchtar
surgical hydrogen peroxide , 95% ethanol + potassium iodide increase digestive:ethanol p.o / potassium iodide
instruments
washing 3% hydrogen peroxide - 0.01-0.1% potassium permanganate - chloramine B 1.5 -2% - healing relief pain and sedation: ethanol in herbivores , i.v.
wounds wound edge by ethanol 95% + potassium iodide - iodophores - 1% chlorhexidine - Birchtar 5-10% p.o
, characterization mechanism of action Absorption Distribution into penetration metabolisation excretion side effect mixing w
relative water- -stop RNA digestive tract tears, bile, milk, -pet with acidosis: diamino
soluble, white production, dogs:very quickly rum: sweat and feces. form crystal in urine.
ne
crystalline replication, protein depends on age and type of feed -mostly from urine
synthesis. - calf: so slowly. -depends on Herbivores and unchanged.
powder, a weak metabolise more
inhibits folic acid horse :drug+feed:slower,biphase(1st MC pka. - -low PH in urin:
organic acid. the soft tissues,
Sulphonamides
synthesis, which is in one h, 2nd 8‒10 h).
CNS, cerebrospinal, acetylation quickly and to a resorption and t1/2
begins 4‒6 hours horse:drug without feed:quick but worst greater extent increases. -in
joint fluid. mostly in liver
after dosing.- than dog. compared to Alkaline urine
thymidine and and lungs. carnivores and excreted higher.
PABA reduces
sulfanilamides omnivores.
activity.
SULFAMERAZIN not indicated for gastrointestinal,Is quick but short-acting -80 % of the circulating plasma Up to 90 % of the not suitable to combined
short&fast acting goats, and cows sulfonamide not used in conjunction with concentration. drug substance is animals suffering trimethopr
producing milk for diuretic furosemide and fluids including the cerebrospinal fluid, 60 excreted in the from kidney, liver, be combin
human hydrochlorothiazide, group B vitamins, % of circulating plasma concentration. urine, the rest ‒ with blood-forming tylosin,
consumption. paraaminobenzoic acid derivatives, MPC after 2‒4 hours and lasts up to 12 sweat, saliva, milk organs diseases, sulfameth
phenacetin, medicines that contain sulfur. hours. and bile. haemorrhagic sulfadiazin
. T½, depending on the species, age and diathesis,
the dose . 2.5 to 14 hours. dehydrated.can
in liver lead to renal failure
SULFADIMIDINE Used p.o. metabolized to N4- gastrointestinal. 80 % drug substance bounds to plasma is a short
short&fast acting therapeutic acetilsulfametazine, proteins,t½ ‒ 5.5 sulfonam
concentration N4-glucose alone or w
reached after 6‒12 sulfametazine tylosin,
hours. compound and chlortetra
desaminosulfametaz penicillin
ine. procaine.
often with
trimethop
SULFADIAZINE gastrointestinal MPC 4‒6 hours. Within 24 hours 50 Dogs sulfadiazine combined
medium&long distributed in the skin, bones, eye tissue, % sulfonamide is tolerated better than trimethopr
acting prostate), but passes the blood-brain excreted in the cats, for which long sulfadimid
used drug causes
barrier with difficulty. urine and 60 % of drowsiness, anorexia,
sulfamera
T½, : 3.5 h up to 37 hours. this amount ‒ anemia, leucopenia. tylosin
Easily penetrates cell membranes. unchanged not used if animal is
Up to 40 % sulfadiazine circulating sensitive , in liver and
plasma is acetylated. kidney damage,
altered blood
composition and laying
hens
characterization mechanism of action Absorption Distribution into penetration metabolisation excretion side effect mixing w
GI, ear, eye tissues, MPC are 2 h, t½ urine (80‒100 %)
cerebrospinal liquid, ‒ 10 hours.It in about 30 % is
SULFAMETHOXAZ the highest penetrates the unchanged
OLE medium&long concentration placental barrier
acting reached after 8 and appear in the
hours.
milk.
medium acting
hydrogen peroxide sulphonamide fluroquenolone Nitrofurans cephalosporine aminoglycoside Pleuromutilin polymyxins
Dihydrostrepto
potassium permanganate sulphamerazine Enrofloxacin nitrufural cephalexin mycin sulphate Tiamulin fumarate Colistin
cephapirin Valnemulin
ethanol sulphadimidine Flumequine nitrufurantion sodium Gentamicin HYDROCHLORIDE Glycopeptides
ceftiofur
,chloramine B, SULFADIAZINE Methenamine sodium Spectinomycin ansamicines
cefovecin
iodine, SULFAMETHOXAZOLE sodium tetracyclines Rifaximin
cefquinome
,chlorhexidine, SULFADIMETHOXINE sulphate Oxytetracycline Past-antibiotic
cationic detergent, SULFACHLORPYRIDAZINE benzylpenicillin procaine salt Doxycycline lincosamides
Ichthammol Trimethoprim phenoxymethylpenicillin Amphenicols Lincomycin
birch tar NAFCILLIN SODIUM Thiamphenicol
CLOXACILLIN SODIUM Florfenicol
AMPICILLIN macrolides
amoxicillin Erythromycin
tulathromycin
tylosin
tylvalosin
, Use for Mechanism of action characteristic Side effect Abso
Hydrogen 3% :local haemostatic,washing wounds,skin peroxidise and catalase decompose,release atomic(from short,weak, poorly -not use for major blood vesseles bec
peroxide 0.3-0.5%:mastitis ,gingivitis (mouth cavity) peroxidase,kill microorganism) and molecular(catalase penetrate make embolism
-As a disinfectant in water treatment and food processing facilities and for sterilization of dental and decompose,formed bubble) oxigen.
surgical instruments. -as a local haemostatic :exposed to the oxygen
fibrinogen quickly turns into fibrin (activates prothrombin)
-against bacteria, spores alittle, mycobacteria, viruses, and fungi. stop bleeding.
potassium 0.01%-0.1%:washing wounds,mouth cavity,stomach intoxication atomic oxigen is formed manganese oxide, which
permangenate 0.01%:algicide reacts with the tissue proteins to form an
1%:virucide albuminates. Therefore, irritats and causticum
alcohols skin.they do not destroy bacterial spores. affect most of enveloped viruses and fungi.efficiency damages bacterial membranes and walls and their Alcohols dry out the skin and can cause local
decreases significantly if the tissues are covered with the excreta, mucus or blood. THE SAFEST ability to coagulate cytoplasmic proteins. inflammation.
ANTISPTIC;
ethanol -Bactericidal is 70 %.in general used in concentrations of 30–90% in aqueous. Ethanol accumulate in the fatty -if it contact with skin or mucous membrane: In the
-In herbivores:improves the secretion of digestive glands, increases digestion, improves motility, reduces tissue, but also in muscle and 2‒3 % ethanol solution causes hyperemia, is elim
fermentation of the stomach or rumen (tympany), in intestinal atony and colics. parenchymal organs. increased glandular secretion. and If the excre
-intravenous:20-33% ethanol solution.normalises blood circulation, increases respiration, increases the body's concentration is high (70‒90 %), ethanol is partly
resistance. Low doses of ethanol, injected intravenously, the body temperature raises, in large doses ‒
reduces.higher than 40% necrosis.
strongly irritating, large amounts of mucus
-For horse , cattle, goat and sheep: sedation p.o. or i.v.; pain relief p.o. or i.v.; to improve digestion p.o.; fever excret, the mucous membrane may be even
reduction p.o.; necrotised.90-95% CNS dysfunction.
-pig ‒ to improve digestion ‒ p.o.; -subcutaneous administration of 40 % ethanol,
-dog ‒ to improve digestion, increase activity ‒ p.o. becomes strongly irritated, possibly even
inflammation occurs
chloramine B not irritate the tissue.has a spermicidal effect. 1.5‒ through formation of undissociated white or yellowish crystalline
2 % solutions are used for wounds, hypochlorous acid (HOCl) in water at acid to powder, with weak chlorine
0.25‒0.5 % solution washed hands or teats odor. 1:20 soluble in water, in
neutral pH. alcohol ‒ 1:25.
iodine -Iodine:Disinfect and prevent bleeding,Especially sensitive to iodine is Staphylococcus spp., E. coli and inhibits important enzymatic systems( interfere with vital . It is poorly soluble in water but -In serose cavities and cysts iodine causes - excr
Proteus spp. metabolic reactions), react with water and release the readily dissolves in ethanol. inflammation and the cavity obliteration. Especially amoun
-is well absorbed through the skin and mucous membranes active -The iodine compound with iodine irritates the mucous membranes bronch
-oral administration potassium iodide acts anti inflammatory as well as metabolic processes activating. oxidizing oxygen.therefor oxidize protein. polyvinyl alcohol does not
-2 % iodine, 6 % of potassium iodide used as an anti-inflammatory and resorption stimulating drug for udder, irritate the skin and mucous
joints, skin, muscle, tendon inflammation, blackleg, boils and treatment of pyoderma. membranes
-Ethanolic 5% iodine solution:
--potassium iodide is dissolved in 95 % ethanol and water is used in surgical practice for initial treatment of the
wound edges and to prepare the surgeon's hands.Slows wound healing. Not to be used externally for cats, as
it causes severe epidermal necrolysis.
--Iodine tincture contains 2% iodine and 2.4% sodium iodide (NaI) dissolved in 50% ethanol; it is used as a
skin disinfectant.
-POVIDONE IODINE . Iodophors. used as skin disinfectants, particularly before surgery and treatment of
wounds and burns. effective against bacteria, viruses, and fungi but less so against spores. Used Utersol .
uterine foam for cattle.and Betadine dermal solution.
--Phosphoric acid is often mixed with iodophors. used in teat dips to control mastitis.
chlorhexidine shampoo,skin,ointment,surgical,dental,wound cleansers, teat dips.. Used for dogs, cats disrupts the cytoplasmic membrane. is unaffected or enhanced by is decressed by high concentrations of organic
chlorhexidine can be toxic. alcohols, quaternary matter (pus, not blood, etc), hard water, and contact
-1% chlorhexidine acetate ointment:wounds cat,dog,horse ammonium compounds, and with cork. It is incompatible with anionic compounds,
- against most gram+ and some gram- bacteria but not against spores,not virus not fungi so much. alkaline pH. including soap.
A 0.1 % aqueous solution is bactericidal against Staphylococcus aureus, Escherichia coli, and
Pseudomonas aeruginosa
cationic not against nonenveloped viruses, mycobacteria, and spores.effective especially in alkaline ph. action from cell membrane.changes in permeability
good for surface not skin.
detergents
,ichthamol -When applied to the affected area shrinks blood vessels, inhibit secretion and exudation.For dark brown,black .Soluble in
external bleeding use 5‒10 % ichthammol solution swabs. water and glycerol..
-reduces pain,partly anesthesise -
anti-inflammatory,keratoplastic substance
-promotes tissue regeneration.
-10‒20 % ointment is used in skin diseases(dermatitis, scabies, dermatomycoses, furunculosis,
pyoderma,eczema), subcutaneous tissue and muscle diseases(cellulitis, myositis) , arthritis,
neuralgia, tendinitis, tendovaginitis,bursitis, mastitis,wounds, burns treatment.
-As fermentation stopping material is applied by mouth 2 % solution or as a bolus.
-Do not use in food-producing animals because for an ichthammol there is no established
MRLs
birch tar or -bandaging of wounds of the hoof and horn. as a keratoplastic tool ‒ in the hoof cracks ‒ 5‒10 % black oily, Containing
ointments, liniments or emulsions. phenol, cresol, guaiacol,
pine tar
-Enters in Wisniewski liniment composition used to treat wounds, ulcers,bed sores, burns and toluene, tar and others
others skin diseases.
-Externally used in chronic skin diseases (weeping dermatitis, eczema, itch).
-Pine tar contains phenol derivatives that provide antimicrobial properties. It has antibacterial,
antiparasitic, irritant, anti-inflammatory and low conc. (3‒5 %) keratoplastic effects.
-Orally can be applied 5 % aqueous emulsion in case of the rumen atony with tympania.
-For respiratory diseases to facilitate coughing can be used tar vapor inhalation.
-Do not use food-producing animals as MRL is not established.
skin disease Iodine 2%+potassium iodide 6%/ Iodine 2% + ethanol 50%+sodium iodide 2.4%/ iodophores/ stop bleeding:3%hydrogen peroxide-iodine- decrease fever:ethanol ,
Ichthamol 10-20%/ Birchtar wisniewski liniment ichthamol 5-10% herb,p.o
anti- iodine 2%+potassium iodide 6% mouth cavity:hydrogen peroxide 0.3-0.5% stomach intoxication: potassium
inflammatory permanganate 0.01-0.1 %
couthing inhalation Birchtar keratoplastic:ichthamol,Birchtar
surgical hydrogen peroxide , 95% ethanol + potassium iodide increase digestive:ethanol p.o / potassium iodide
instruments
washing 3% hydrogen peroxide - 0.01-0.1% potassium permanganate - chloramine B 1.5 -2% - healing relief pain and sedation: ethanol in herbivores , i.v.
wounds wound edge by ethanol 95% + potassium iodide - iodophores - 1% chlorhexidine - Birchtar 5-10% p.o
, characterization mechanism of action Absorption Distribution into penetration metabolisation excretion side effect mixing w
relative water- -stop RNA digestive tract tears, bile, milk, -pet with acidosis: diamino
soluble, white production, dogs:very quickly rum: sweat and feces. form crystal in urine.
ne
crystalline replication, protein depends on age and type of feed -mostly from urine
synthesis. - calf: so slowly. -depends on Herbivores and unchanged.
powder, a weak metabolise more
inhibits folic acid horse :drug+feed:slower,biphase(1st MC pka. - -low PH in urin:
organic acid. the soft tissues,
Sulphonamides
synthesis, which is in one h, 2nd 8‒10 h).
CNS, cerebrospinal, acetylation quickly and to a resorption and t1/2
begins 4‒6 hours horse:drug without feed:quick but worst greater extent increases. -in
joint fluid. mostly in liver
after dosing.- than dog. compared to Alkaline urine
thymidine and and lungs. carnivores and excreted higher.
PABA reduces
sulfanilamides omnivores.
activity.
SULFAMERAZIN not indicated for gastrointestinal,Is quick but short-acting -80 % of the circulating plasma Up to 90 % of the not suitable to combined
short&fast acting goats, and cows sulfonamide not used in conjunction with concentration. drug substance is animals suffering trimethopr
producing milk for diuretic furosemide and fluids including the cerebrospinal fluid, 60 excreted in the from kidney, liver, be combin
human hydrochlorothiazide, group B vitamins, % of circulating plasma concentration. urine, the rest ‒ with blood-forming tylosin,
consumption. paraaminobenzoic acid derivatives, MPC after 2‒4 hours and lasts up to 12 sweat, saliva, milk organs diseases, sulfameth
phenacetin, medicines that contain sulfur. hours. and bile. haemorrhagic sulfadiazin
. T½, depending on the species, age and diathesis,
the dose . 2.5 to 14 hours. dehydrated.can
in liver lead to renal failure
SULFADIMIDINE Used p.o. metabolized to N4- gastrointestinal. 80 % drug substance bounds to plasma is a short
short&fast acting therapeutic acetilsulfametazine, proteins,t½ ‒ 5.5 sulfonam
concentration N4-glucose alone or w
reached after 6‒12 sulfametazine tylosin,
hours. compound and chlortetra
desaminosulfametaz penicillin
ine. procaine.
often with
trimethop
SULFADIAZINE gastrointestinal MPC 4‒6 hours. Within 24 hours 50 Dogs sulfadiazine combined
medium&long distributed in the skin, bones, eye tissue, % sulfonamide is tolerated better than trimethopr
acting prostate), but passes the blood-brain excreted in the cats, for which long sulfadimid
used drug causes
barrier with difficulty. urine and 60 % of drowsiness, anorexia,
sulfamera
T½, : 3.5 h up to 37 hours. this amount ‒ anemia, leucopenia. tylosin
Easily penetrates cell membranes. unchanged not used if animal is
Up to 40 % sulfadiazine circulating sensitive , in liver and
plasma is acetylated. kidney damage,
altered blood
composition and laying
hens
characterization mechanism of action Absorption Distribution into penetration metabolisation excretion side effect mixing w
GI, ear, eye tissues, MPC are 2 h, t½ urine (80‒100 %)
cerebrospinal liquid, ‒ 10 hours.It in about 30 % is
SULFAMETHOXAZ the highest penetrates the unchanged
OLE medium&long concentration placental barrier
acting reached after 8 and appear in the
hours.
milk.
medium acting
