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PHARM 615 EXAM 3 MARYVILLE STUDY GUIDE | 2025/2026

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PHARM 615 EXAM 3 MARYVILLE STUDY GUIDE | 2025/2026 1. What vitamin will decrease peripheral neuropathy? The use of pyridoxine or Vitamin B6 can be administered for patients who are on isoniazid therapy for tuberculosis 2. What lab values should be assessed when administering valacyclovir? Some antiviral drugs that are effective in treating herpes including acyclovir (first discovered and also available in generic form), valacyclovir (also available in generic form), famcyclovir, and pencyclovir. 10% of Valacyclovir is metabolized by the liver, while 90% is metabolized by the kidney. Thus, Blood Urea Nitrogen (BUN) and creatinine levels should be assessed prior to administering Valacyclovir. Food slows down the absorption, but overall, it does not affect the absorption of valcyclovir. Valacyclovir should be taken with a full glass of water and the patient should increase the water intake.

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PHARM 615 EXAM 3 MARYVILLE STUDY GUIDE | 2025/2026




1. What vitamin will decrease The use of pyridoxine or Vitamin B6 can be administered for

peripheral neuropathy? patients who are on isoniazid therapy for tuberculosis

Some antiviral drugs that are effective in treating herpes

including acyclovir (first discovered and also available in

generic form), valacyclovir (also available in generic

form), famcyclovir, and pencyclovir. 10% of Valacyclovir is

2. What lab values should be metabolized by the liver, while 90% is metabolized by the

assessed when administering kidney. Thus, Blood Urea Nitrogen (BUN) and creatinine

valacyclovir? levels should be assessed prior to administering

Valacyclovir. Food slows down the absorption, but

overall, it does not affect the absorption of valcyclovir.

Valacyclovir should be taken with a full glass of water and

the patient should increase the water intake.

Oseltamivit, marketed under the trade name Tamiflu, is an

antiviral medication used to treat influenza A and influenza B

3. When should oseltamivir and to prevent flu after exposure. The medications taken

phosphate be prescribed? orally. The CDC recommends use of oseltamivir for

people who have complications or are at high risk for

complications who percent within 48 hours of the first

, symptoms infection.

Rifampin is an antibiotic used to treat a number of bacterial

infections. This includes tuberculosis, leprosy, and legionella

among others. It often is used with other antibiotics. It is also

used to prevent haemophilus influenzae type b and

meningococcal disease in those who have been exposed,

such as people who live in close quarters like soldiers and

4. For what is rifampin prescribed? college students. Before treating someone for a long period

of time testing the liver function and blood counts are

recommended. It is available by mouth and IV. It is also part

of the recommended treatment of active tuberculosis during

pregnancy, even though its safety and pregnancy is not

known. Rifampin is of the erythromycin group of

antibiotics and works. by stopping production of

bacterial RNA

, The adverse effects of Isoniazid that is an antibiotic used a

first line agent for the prevention and treatment of

tuberculosis include; Peripheral neuropathy which is involved

in patients taking isoniazid and it occurs in about 2% of

patients taking 5 mg/kg/d, and the prevalence is higher for

patients taking higher doses, up to about 44% for patients

taking 16 mg/kg/d. The symptoms of peripheral neuropathy

include symmetrical numbness and tingling in the

extremities. The patients who are predisposed to this

adverse reaction include people who are malnourished,

slow acetylators, pregnant women, older adults, diabetics,

and patients with chronic liver disease, including alcoholics.

Peripheral neuropathy with the use of isonazid can be
5. What are the adverse effects
prevented with the use of Pyridoxine (Vitamin B6) and is
of isoniazid (INH)?
recommended for patients in the at-risk groups. The

recommended prophylactic doses range from 10 to 50 mg

daily, while the treatment of established neuropathy requires

50 to 200 mg daily.

Other adverse effects include; elevated serum

transaminases (AST/ALT; liver enzymes) observed in 10% to

20% of patients taking isoniazid occurring usually in the first

3 months of therapy that is asymptomatic, and will return to

normal with continued isoniazid therapy. However, in a small

portion of patients (0.4%), this condition may progress to

hepatic failure or necrosis, and progressive liver damage

that increases with age and the risk is increased by

concurrent alcohol use, and increased 4-fold with concurrent

rifampin administration. In addition, some adverse reactions

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