Terms in this set (60)
Serotonin-Dopamine Antagonist
Quetiapine (Seroquel)
Atypical antipsychotic
Psychotic and manic symptoms can improve within one
How long does it take for
week. It will take several week to have full effect on
quetiapine (Seroquel) to work
behavior. Recommended to wait 4-6 weeks to determine
efficacy. May take 16-20 weeks to show good response
on cognitive symptoms
What does quetiapine do? Decrease positive symptoms of schizophrenia 3 multiple choice
options
BMI
What should be monitored
closely before patients are on Waist circumference
atypical antipsychotics? Blood glucose levels (fasting blood glucose between 100-125)
Sedation (by blocking H1 receptors)
Dizziness, sedation, hypotension (by blocking alpha 1
How are side effects of adrenergic receptors Dry mouth, constipation, sedation
quetiapine caused? (by blocking muscarinic 1 receptors) Weight gain,
increased incidence of diabetes, dislipidemia, (reason
for cause unknown)
, Weight gain based on dose
Increased risk for diabetes and
dyslipidemia Dizziness
Sedation
Constipatio
What are the side effects of n Dry
quetiapine? mouth
Dyspepsia
Orthostatic hypotension (in the beginning trial
period) Potentially tardive dyskinesia
, 1. Hyperglycemia causing ketoacidosis or Hyperosmolar
hyperglycemic state (HHS) is a complication of diabetes
mellitus in which high blood sugar results in high
osmolarity without significant ketoacidosis.
What are adverse effects of (resulting in coma)
quetiapine (potentially life 2. NMS
threatening)
3. Seizures
4. Increased risk of death and cerebral vascular incident
Aripiprazole (Abilify, Aristada) atypical antipsychotic (sometimes second generation) 2 multiple
choice options
Schizophrenia
Maintaining stability in
Aripiprazole is commonly schizophrenia Depression
prescribed for Autism related irritability
1. Partial agonism at dopamine 2 receptors
2. Reduces dopamine output when dopamine is high
thus improving positive symptoms and mediating
antipsychotic actions.
How does aripiprazole work? 3. Increases dopamine output when dopamine levels
are low thus improving cognition, negative, and
mood symptoms
4. Also acts on dopamine 3 receptors
5. Blocks serotonin 2A receptors thus increasing dopamine
How long does it take May begin working in one week. It is best to wait 4-6 weeks to see full
aripiprazole to work? efficacy.
1. Blocking alpha 1 adrenergic receptors causing
dizziness, sedation, and hypertension