NR 546 week 5 (Latest Update 2025 /
2026) Advanced Pharmacology:
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner
Questions & Answers100% Correct
[Grade A] – Chamberlain
Neural Networks of MDD and BPD -correct answer The classic monoamine hypothesis
of depression posits that depression occurs as a result of a deficiency of one or all three
monoamine transmitters (serotonin, norepinephrine, and dopamine), while mania may
result from an excess; however, this hypothesis has limitations. Stahl (2021)
acknowledged that depression is more complex than this simple theory but agrees that
the monoamine hypothesis is helpful to understand the physiological functioning of
these NTs. Emphasis is now shifted from the monoamines to their receptors and other
downstream events such as the regulation of gene expression, growth factors,
environmental factors, and epigenetic changes (Stahl, 2021).
Neural Signaling of MDD and BPD -correct answer Three principal neurotransmitters,
norepinephrine (NE), dopamine (DA), and serotonin 5HT, have implications for the
pathophysiology and treatment of mood disorders. Norepinephrine, dopamine, and
serotonin are monoamines. Monoamines work in concert and comprise the monoamine
neurotransmitter system. Many of the symptoms of mood disorders are hypothesized to
involve dysfunction of various combinations of the monoamine neurotransmitters. All
known pharmacologic treatments for mood disorders act upon one or more of these
three neurotransmitters.
symptoms in dysfunction: prefrontal cortex (PFC) -correct answer Concentration,
Mental fatigue, Mood
symptoms in dysfunction: striatum -correct answer Physical fatigue
, NR 546 week 5 (Latest Update 2025 /
2026) Advanced Pharmacology:
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner
Questions & Answers100% Correct
[Grade A] – Chamberlain
symptoms in dysfunction: nucleus accumbens -correct answer Pleasure interests
symptoms in dysfunction: hypothalamus -correct answer Sleep, appetite
symptoms in dysfunction: prefrontal cortex (PFC) and amygdala -correct answer Guilt,
suicidality, worthlessness
symptoms in dysfunction: thalamus and hypothalamus -correct answer Decreased
sleep/arousal
symptoms in dysfunction: striatum -correct answer Motor/agitation
symptoms in dysfunction: nucleus accumbens and the prefrontal cortex (PFC) -correct
answer Racing thoughts, grandiosity
symptoms in dysfunction: prefrontal cortex ((PFC) -correct answer Talkative/pressured
speech
symptoms in dysfunction: prefrontal cortex (PFC) and the amygdala -correct answer
Mood
symptoms in dysfunction: prefrontal cortex (PFC) -correct answer Risk taking
, NR 546 week 5 (Latest Update 2025 /
2026) Advanced Pharmacology:
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner
Questions & Answers100% Correct
[Grade A] – Chamberlain
First-line Treatment drug classes for depression -correct answer Selective Serotonin
Reuptake Inhibitors (SSRIs)
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
Norepinephrine Dopamine Reuptake Inhibitors (NDRI)
Serotonin Antagonist and Reuptake Inhibitors (SARIs
mechanism of action
Selective Serotonin Reuptake Inhibitors (SSRIs) -correct answer inhibits 5-HT reuptake
mechanism of action.
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) -correct answer inhibit 5-HT
reuptakeinhibit NE reuptake (↑ energy, focus)increase DA in prefrontal cortex (↑
cognition
mechanism of action.
Norepinephrine Dopamine Reuptake Inhibitors (NDRI) -correct answer inhibit DA
reuptake (↑alertness, motivation)inhibit NE reuptake (↑energy)
Adverse Effects of SSRI -correct answer diarrhea
headache
weight gain
sexual side effects
Adverse Effects of SNRI -correct answer elevated blood pressure
2026) Advanced Pharmacology:
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner
Questions & Answers100% Correct
[Grade A] – Chamberlain
Neural Networks of MDD and BPD -correct answer The classic monoamine hypothesis
of depression posits that depression occurs as a result of a deficiency of one or all three
monoamine transmitters (serotonin, norepinephrine, and dopamine), while mania may
result from an excess; however, this hypothesis has limitations. Stahl (2021)
acknowledged that depression is more complex than this simple theory but agrees that
the monoamine hypothesis is helpful to understand the physiological functioning of
these NTs. Emphasis is now shifted from the monoamines to their receptors and other
downstream events such as the regulation of gene expression, growth factors,
environmental factors, and epigenetic changes (Stahl, 2021).
Neural Signaling of MDD and BPD -correct answer Three principal neurotransmitters,
norepinephrine (NE), dopamine (DA), and serotonin 5HT, have implications for the
pathophysiology and treatment of mood disorders. Norepinephrine, dopamine, and
serotonin are monoamines. Monoamines work in concert and comprise the monoamine
neurotransmitter system. Many of the symptoms of mood disorders are hypothesized to
involve dysfunction of various combinations of the monoamine neurotransmitters. All
known pharmacologic treatments for mood disorders act upon one or more of these
three neurotransmitters.
symptoms in dysfunction: prefrontal cortex (PFC) -correct answer Concentration,
Mental fatigue, Mood
symptoms in dysfunction: striatum -correct answer Physical fatigue
, NR 546 week 5 (Latest Update 2025 /
2026) Advanced Pharmacology:
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner
Questions & Answers100% Correct
[Grade A] – Chamberlain
symptoms in dysfunction: nucleus accumbens -correct answer Pleasure interests
symptoms in dysfunction: hypothalamus -correct answer Sleep, appetite
symptoms in dysfunction: prefrontal cortex (PFC) and amygdala -correct answer Guilt,
suicidality, worthlessness
symptoms in dysfunction: thalamus and hypothalamus -correct answer Decreased
sleep/arousal
symptoms in dysfunction: striatum -correct answer Motor/agitation
symptoms in dysfunction: nucleus accumbens and the prefrontal cortex (PFC) -correct
answer Racing thoughts, grandiosity
symptoms in dysfunction: prefrontal cortex ((PFC) -correct answer Talkative/pressured
speech
symptoms in dysfunction: prefrontal cortex (PFC) and the amygdala -correct answer
Mood
symptoms in dysfunction: prefrontal cortex (PFC) -correct answer Risk taking
, NR 546 week 5 (Latest Update 2025 /
2026) Advanced Pharmacology:
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner
Questions & Answers100% Correct
[Grade A] – Chamberlain
First-line Treatment drug classes for depression -correct answer Selective Serotonin
Reuptake Inhibitors (SSRIs)
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
Norepinephrine Dopamine Reuptake Inhibitors (NDRI)
Serotonin Antagonist and Reuptake Inhibitors (SARIs
mechanism of action
Selective Serotonin Reuptake Inhibitors (SSRIs) -correct answer inhibits 5-HT reuptake
mechanism of action.
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) -correct answer inhibit 5-HT
reuptakeinhibit NE reuptake (↑ energy, focus)increase DA in prefrontal cortex (↑
cognition
mechanism of action.
Norepinephrine Dopamine Reuptake Inhibitors (NDRI) -correct answer inhibit DA
reuptake (↑alertness, motivation)inhibit NE reuptake (↑energy)
Adverse Effects of SSRI -correct answer diarrhea
headache
weight gain
sexual side effects
Adverse Effects of SNRI -correct answer elevated blood pressure
