NR546 COMBINED FINAL SET QUESTIONS WITH CORRECT VERIFIED ANSWERS | 100% PASS (A+ CERTIFIED)

NR546 COMBINED FINAL SET QUESTIONS WITH CORRECT VERIFIED ANSWERS | 100% PASS (A+ CERTIFIED) Monoamine Hypothesis Correct Answer Deficiency in serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Guides antidepressant selection based on symptom profile. SSRIs Correct Answer Screen for cardiac issues, bipolar disorder. Caution: 25 years (suicide risk). Sertraline Correct Answer Least CYP interaction, good tolerance. Paroxetine Correct Answer Discontinuation syndrome. Fluoxetine, Sertraline Correct Answer Early activation. Lithium Interactions Correct Answer Increase levels: NSAIDs, ACE inhibitors, thiazide diuretics. Decrease levels: Caffeine, theophylline. Serotonin Syndrome Correct Answer Symptoms: Agitation, clonus, hyperthermia. Causes: Combining serotonergic drugs. Pharmacologic Adjuncts Correct Answer Buspirone, atypical antipsychotics, L-methylfolate. Medication Comparisons Correct Answer SSRIs + Stimulants: Can worsen anxiety. Buspirone similar to SSRIs. MAOIs Correct Answer Short half-life; irreversible. Tyramine food interactions. Bipolar Disorder Correct Answer Mood stabilizers: Lithium, valproic acid, carbamazepine, lamotrigine. General Medication Knowledge Correct Answer Avoid bupropion in eating disorders (seizure risk). Trazodone risk: Priapism. Elderly-safe Correct Answer Sertraline, escitalopram. QTc prolongation Correct Answer Citalopram. L-Methylfolate Correct Answer Active folate form, supports neurotransmitter synthesis. Reward Circuits Correct Answer VTA to Nucleus accumbens (dopamine). Prefrontal cortex: Impulse control. Amygdala: Emotional memory. Addiction Medications Correct Answer Alcohol: Naltrexone, acamprosate, disulfiram. Opioids: Methadone, buprenorphine, naltrexone. Nicotine: NRT, varenicline, bupropion. Initiation Protocols Correct Answer Buprenorphine: After mild withdrawal (COWS greater than or equal to 8-12). Naltrexone (opioid): 7-10 days opioid-free. Substances of Abuse Correct Answer Opioids: Pinpoint pupils. Stimulants: Dilated pupils. Cannabis: Red eyes. Medication Timing Correct Answer Methadone: Immediate. Acamprosate: Post-detox. Lifespan Considerations Correct Answer Pregnancy: Methadone, buprenorphine. Elderly: Avoid varenicline (in frail elderly). ADHD Pathophysiology Correct Answer Prefrontal cortex dysfunction. DA and NE deficiencies. Stimulant vs Non-Stimulant Correct Answer Stimulants: Fast-acting, abuse risk. Non-stimulants: Slower, safer in anxiety/substance abuse. Lifespan Considerations for ADHD Correct Answer Children: Methylphenidate XR. Adults: Amphetamine salts XR. Elderly: Atomoxetine preferred. Anxiety-Exacerbating Combos Correct Answer SSRIs + Stimulants, stimulants + bupropion. Mechanisms of ADHD Medications Correct Answer Stimulants: Block NE/DA reuptake. Atomoxetine: Selective NE reuptake inhibitor. Guanfacine/Clonidine: Alpha-2 agonists. Extended-Release Impact Correct Answer Reduces dopamine peaks, lowers abuse potential. Delivery Forms