NURS5334 / NURS 5334: PSYCHIATRY STUDY
GUIDE | TERMS & COMPLETE DEFINITIONS | NEWEST
UPDATE 2025/2026 | UNIVERSITY OF TEXAS,
ARLINGTON*ARLINGTON, TEXAS
Antidepressants
Selective Serotonin Reuptake Inhibitors (SSRIs)
Fluoxetine (Prozac) Delayed onset of action, indicated for MDD, GAD, panic
disorder, OCD, PTSD, inappropriate sexual desire, AE: nausea,
Citalopram
sexual dysfunction, serotonin syndrome
Paroxetine
Escitalopram (Lexapro) Best AE profile of all SSRIs
Sertraline (Zoloft)
Serotonin Modulators
Trazodone Indicated for MDD and insomnia, AE: drowsiness
Nefazodone Less sedating than trazodone, BBW: hepatotoxicity
Vilazodone
Vortioxetine
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Duloxetine (Cymbalta) AE: orthostatic hypotension Indicated for MDD, GAD,
diabetic neuropathic pain,
Venlafaxine (Effexor)
AE: hypertension
Desvenlafaxine AE: hyperlipidemia
Levomilnacipran
Tricyclic Antidepressants (TCAs) (-pramine/-triptyline)
, Amitriptyline Indicated for MDD, insomnia and neuropathic pain (amitriptyline), OCD
(clomipramine), AE: sedation, anticholinergic effects, phenothiazine
Nortriptyline
effects, arrythmia, seizures
Clomipramine
Imipramine
Desipramine
Doxepin
Tetracyclic Antidepressants (TeCAs)
Amoxapine Indicated for MDD with psychosis
Mirtazapine Avoids sexual dysfunction, AE: weight gain
Monoamine Oxidase Inhibitors (MAOIs)
Isocarboxazid Long-lasting effects, 3rd line agent, AE: higher potential for serotonin
syndrome
Phenelzine
Selegiline
Tranylcypromine
NMDA Receptor Antagonist
Ketamine Promotes glutamine release, indicated for resistant MDD
Esketamine
Dextromethorphan/bupropion
Other Agents
Bupropion Indicated for MDD, smoking cessation, ADHD, AE: seizures
Zuranolone Indicated for post-partum depression, AE: impaired ability to drive
St. John’s Wort Unproven effectiveness
Anxiety
Generalized Anxiety Disorder
SSRIs Paroxetine, escitalopram, sertraline
SNRIs Duloxetine, venlafaxine
Pregabalin 2nd line agents
Imipramine
Buspirone Augmentation agent when SSRIs/SNRIs are partially responsive
Benzodiazepines For acute symptoms (alprazolam, lorazepam, clonazepam, diazepam)
Hydroxyzine Alternative agent
GUIDE | TERMS & COMPLETE DEFINITIONS | NEWEST
UPDATE 2025/2026 | UNIVERSITY OF TEXAS,
ARLINGTON*ARLINGTON, TEXAS
Antidepressants
Selective Serotonin Reuptake Inhibitors (SSRIs)
Fluoxetine (Prozac) Delayed onset of action, indicated for MDD, GAD, panic
disorder, OCD, PTSD, inappropriate sexual desire, AE: nausea,
Citalopram
sexual dysfunction, serotonin syndrome
Paroxetine
Escitalopram (Lexapro) Best AE profile of all SSRIs
Sertraline (Zoloft)
Serotonin Modulators
Trazodone Indicated for MDD and insomnia, AE: drowsiness
Nefazodone Less sedating than trazodone, BBW: hepatotoxicity
Vilazodone
Vortioxetine
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Duloxetine (Cymbalta) AE: orthostatic hypotension Indicated for MDD, GAD,
diabetic neuropathic pain,
Venlafaxine (Effexor)
AE: hypertension
Desvenlafaxine AE: hyperlipidemia
Levomilnacipran
Tricyclic Antidepressants (TCAs) (-pramine/-triptyline)
, Amitriptyline Indicated for MDD, insomnia and neuropathic pain (amitriptyline), OCD
(clomipramine), AE: sedation, anticholinergic effects, phenothiazine
Nortriptyline
effects, arrythmia, seizures
Clomipramine
Imipramine
Desipramine
Doxepin
Tetracyclic Antidepressants (TeCAs)
Amoxapine Indicated for MDD with psychosis
Mirtazapine Avoids sexual dysfunction, AE: weight gain
Monoamine Oxidase Inhibitors (MAOIs)
Isocarboxazid Long-lasting effects, 3rd line agent, AE: higher potential for serotonin
syndrome
Phenelzine
Selegiline
Tranylcypromine
NMDA Receptor Antagonist
Ketamine Promotes glutamine release, indicated for resistant MDD
Esketamine
Dextromethorphan/bupropion
Other Agents
Bupropion Indicated for MDD, smoking cessation, ADHD, AE: seizures
Zuranolone Indicated for post-partum depression, AE: impaired ability to drive
St. John’s Wort Unproven effectiveness
Anxiety
Generalized Anxiety Disorder
SSRIs Paroxetine, escitalopram, sertraline
SNRIs Duloxetine, venlafaxine
Pregabalin 2nd line agents
Imipramine
Buspirone Augmentation agent when SSRIs/SNRIs are partially responsive
Benzodiazepines For acute symptoms (alprazolam, lorazepam, clonazepam, diazepam)
Hydroxyzine Alternative agent
