Cancer Class Lecture (Exam 1) ACTUAL
QUESTIONS AND CORRECT ANSWERS
Tumor cells - CORRECT ANSWERS Involves one cell type
Paget's seed and soil hypothesis - CORRECT ANSWERS Particularly important in
metastasis but also relevant to primary tumors
Stroma (connective and supportive tissue) - CORRECT ANSWERS Provides a
microenvironment (the so-called congenial soil)
Tumors - CORRECT ANSWERS Manipulate the stroma to get the nutrients and to remain
protected from the immune system
Components of tumor microenvironment - CORRECT ANSWERS Extracellular matrix,
fibroblasts, pericytes and endothelial cells, innate immune cells, adaptive immune cells
Extra cellular matrix - CORRECT ANSWERS Acellular
Fibroblasts - CORRECT ANSWERS Predominant cell of the connective tissue
Pericytes and endothelial cells - CORRECT ANSWERS Components of blood vessels
Innate immune cells - CORRECT ANSWERS Macrophages, dendritic cells, etc.
Adaptive immune cells - CORRECT ANSWERS Regulatory T cells
, Extracellular matrix importance - CORRECT ANSWERS Determines the arrangement of
cells in tissues
Basement membrane - CORRECT ANSWERS Anchors epithelial tissues
Invasive tumors - CORRECT ANSWERS Break through the basement membrane and then
it must navigate and remodel the interstitial extracellular matrix to further invade into the organ
Matrix metalloproteinanses (MMPs) - CORRECT ANSWERS ECM remodeling enzymes
MMP inhibitors - CORRECT ANSWERS Have been invested in clinical trials, but all have
failed
Fibroblast structure and function - CORRECT ANSWERS Connective tissue that
produces/arranges the extracellular matrix, coordinates growth of other cells through growth
factors, influences immune cell recruitment, and moves toward sites of injury
Cancer-associated fibroblasts - CORRECT ANSWERS Are similar to activated fibroblasts
during wound healing (can secrete growth factors/influence immune system activity to aid tumor
growth and contribute to drug resistance
Epithelial to mesenchymal transition - CORRECT ANSWERS Can be necessary for
invasion and metastasis; can be mediated by fibroblasts
Two types of cancer-associated immune cells - CORRECT ANSWERS Innate and
adaptive immune cells
QUESTIONS AND CORRECT ANSWERS
Tumor cells - CORRECT ANSWERS Involves one cell type
Paget's seed and soil hypothesis - CORRECT ANSWERS Particularly important in
metastasis but also relevant to primary tumors
Stroma (connective and supportive tissue) - CORRECT ANSWERS Provides a
microenvironment (the so-called congenial soil)
Tumors - CORRECT ANSWERS Manipulate the stroma to get the nutrients and to remain
protected from the immune system
Components of tumor microenvironment - CORRECT ANSWERS Extracellular matrix,
fibroblasts, pericytes and endothelial cells, innate immune cells, adaptive immune cells
Extra cellular matrix - CORRECT ANSWERS Acellular
Fibroblasts - CORRECT ANSWERS Predominant cell of the connective tissue
Pericytes and endothelial cells - CORRECT ANSWERS Components of blood vessels
Innate immune cells - CORRECT ANSWERS Macrophages, dendritic cells, etc.
Adaptive immune cells - CORRECT ANSWERS Regulatory T cells
, Extracellular matrix importance - CORRECT ANSWERS Determines the arrangement of
cells in tissues
Basement membrane - CORRECT ANSWERS Anchors epithelial tissues
Invasive tumors - CORRECT ANSWERS Break through the basement membrane and then
it must navigate and remodel the interstitial extracellular matrix to further invade into the organ
Matrix metalloproteinanses (MMPs) - CORRECT ANSWERS ECM remodeling enzymes
MMP inhibitors - CORRECT ANSWERS Have been invested in clinical trials, but all have
failed
Fibroblast structure and function - CORRECT ANSWERS Connective tissue that
produces/arranges the extracellular matrix, coordinates growth of other cells through growth
factors, influences immune cell recruitment, and moves toward sites of injury
Cancer-associated fibroblasts - CORRECT ANSWERS Are similar to activated fibroblasts
during wound healing (can secrete growth factors/influence immune system activity to aid tumor
growth and contribute to drug resistance
Epithelial to mesenchymal transition - CORRECT ANSWERS Can be necessary for
invasion and metastasis; can be mediated by fibroblasts
Two types of cancer-associated immune cells - CORRECT ANSWERS Innate and
adaptive immune cells
