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MLS ASCP Exam 2025: Practice Questions, Study Guide & Prep Tips

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Get ready for the MLS ASCP certification exam with the newest 2025 practice test. This PDF includes actual exam-style questions, detailed answer explanations, and key topics for Medical Laboratory Science. Download your ultimate study guide to pass the ASCP MLS exam on your first try.

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MLS ASCP Actual Exam Newest 2025/2026
Complete All Questions And Correct Detailed
Answers (Verified Answers) |Already Graded
A+||Brand New Version!!


Procainamide - . . ANSWER ✔ ✔-Answer: NAPA
-p. 86-Ant antiarrhythmic drug that has a metabolite with
the same drug action
-Procainamide is metabolized to N-Acetylprocainamide
(NAPA)
- Must quantify both. Although they have the same drug
affect, difference in half- life may cause NAPA to
accumulate in the blood and produce toxic affects even at
therapeutic levels of procainamide.


loose clusters of small spherical microconidia, positive
urease - . . ANSWER ✔ ✔-Answer: Trichophyton
mentagrophytes -Trichophyton is the only Dermatophyte
with two colony types : macroconidia and microconidia. -
T. mentagrophytes characteristically produce "grapelike
clusters" of microconidia. - Positive in the hair perforation
test.

,2|Page


Beta -HCG tumor marker - . . ANSWER ✔ ✔Answer:
chorocarcinoma
-The are are 2 forms of hCG Alpha (common form) and
Beta (unique form)


5HIAA 5-hydroxyindoleacetic acid - . . ANSWER ✔ ✔-
Answer: carcinoid tumors -5HIAA: primary metabolite of
serotonin, a chemical substance (neurotransmitter) that
transmits messages between nerve cells. -Large quantities
of serotonin and 5-HIAA may be produced by some
carcinoid tumors.- Carcinoid tumors are slow-growing
noncancerous or cancerous neuroendocrine masses that
can form in the GI tract, especially in the appendix, and in
the lungs.


Proteus vulgaris vs P. mirabilis indole test - . . ANSWER ✔
✔P. vulgaris is indole pos. P. mirabilis is indole neg


Hydatid cyst fluid - . . ANSWER ✔ ✔used to neutralize
Anti-P1 antibody


Antacid overdose - . . ANSWER ✔ ✔Check pH

,3|Page


Prolonged PT, PTT, and thrombin after collecting from
catheter - . . ANSWER ✔ ✔heparin contamination


mixing study that was performed with a prolonged PTT
that couldn't be corrected - . . ANSWER ✔ ✔DRVVT
(Dilute Russell Viper Venom Test)


two pt's ran in duplicate (PT and PTT). The PTT seemed to
always be prolonged but PT looked ok - . . ANSWER ✔
✔check the CaCl/phospholipid reagent delivery


Patient is on coumadin therapy, what will be affected - . .
ANSWER ✔ ✔Decreased protein C


Lot's of stomatocytes - . . ANSWER ✔ ✔Liver disease


Burr cells - . . ANSWER ✔ ✔Uremia


Picture of target cells with hemoglobin C crystals. The
white count was high on instrument 1, so a second
instrument was used with a stronger lysing agent, and the
white count was corrected - . . ANSWER ✔ ✔anti-lysing

, 4|Page


target cells are what increased the white count?
Erythrocytes containing hemoglobin C do not lyse
normally (sickle cell diseases)


A sodium citrate tube was drawn for a HCT on a pt but the
hematocrit was abnormal - . . ANSWER ✔ ✔recollect with
decreased anticoagulant. high hct (>55%) causes low
plasma so you need less anticoagulant


Question that gives a red blood cells count, HGB, and
HCT. I did the rule of 3 and found that the HGB didn't
meet the rule of 3 because it was too high - . . ANSWER ✔
✔check for lipemia (elevates HGB)


PBS with an elevated reticulocyte count and howell jolly
bodies in the RBC's - . . ANSWER ✔ ✔-Answer: howell
jolly bodies= DNA= Wright Stain
-Peppenheimer- Prussian blue stain
-which is not taken up by reticulocytes
-helpful in differentiating the two.
-Reticulocytes=Supravital/ new methylene blue stain

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