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WGU D236 Pathophysiology Final Exam – 2025/2026 | 100 Questions | Systems Disorders, Labs, Inflammation, Hormones | Western Governors University

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This document provides a complete set of 100 multiple-choice questions and correct answers from the 2025/2026 Pathophysiology Final Exam for D236 at Western Governors University (WGU). It is designed as a focused, high-yield review tool for students preparing for final assessments, clinical application exams, or national licensing prep like the NCLEX. The material covers all major physiological systems and associated disease processes, including: Neurological (CVA, Alzheimer’s, Parkinson’s) Cardiac and circulatory (MI, CHF, DVT) Respiratory (asthma, COPD, pneumonia, ARDS) Endocrine (diabetes types 1 & 2, DKA, thyroid disorders) Renal (AKI, CKD, electrolyte balance) Gastrointestinal (hepatitis, Crohn’s, ulcerative colitis) Hematologic (anemia types, coagulation, sickle cell) Immune and inflammatory responses (cytokines, autoimmunity) Reproductive and Integumentary (STIs, skin lesions, burns) It also includes clinical lab interpretation, RAAS regulation, hormone pathways, and acute vs chronic disease management, all presented in NCLEX-style question formatting to build confidence in both knowledge retention and clinical reasoning. Recommended for: BSN and RN-to-BSN students at WGU Nursing students preparing for D236 exams Pre-licensure and NCLEX candidates Allied health students in medical science courses Learners reviewing disease pathogenesis and clinical correlations Keywords: WGU D236 pathophysiology, nursing final exam, disease mechanisms, endocrine disorders, cardiovascular conditions, lab values and diagnosis, immune response, RAAS system, fluid and electrolyte balance, NCLEX patho prep, GI and renal disease, inflammation cytokines, integumentary system disorders

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WGU Pathophysiology D236 2025/2026
Exam Questions and Correct Answers |
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What is Starling's Law of Capillary forces?




How does this explain why a nutritionally deficient child would have

edema? - 🧠ANSWER ✔✔Starling's Law describes how fluids move across

the capillary membrane. There are two major opposing forces that act to

balance each other, hydrostatic pressure (pushing water out of the

capillaries) and osmotic pressure (including oncontic pressure, which

pushes fluid into the capillaries).




Both electrolytes and proteins (oncontic pressure) in the blood affect

osmotic pressure, high electrolyte and protein concentrations in the blood

,would cause water to leave the cells and interstitial space and enter the

blood stream to dilute the high concentrations.




On, the other hand, low electrolyte and protein concentrations (as seen in a

nutritionally deficient child) would cause water to leave the capillaries and

enter the cells and interstitial fluid which can lead to edema.

How does the RAAS (Renin-Angiotensin-Aldosterone System) result in

increased blood volume and increased blood pressure? - 🧠ANSWER ✔✔A

drop in blood pressure is sensed by the kidneys by low perfusion, which in

turn begins to secrete renin.




Renin then triggers the liver to produce angiotensinogen, which is

converted to Angiotensin I in the lungs and then angiotensin II by the

enzyme




Angiotensin-converting enzyme (ACE). Angiotensin II stimulates peripheral

arterial vasoconstriction which raises BP.

,Angiotensin II is also stimulating the adrenal gland to release aldosterone,

which acts to increase sodium and water reabsorption increasing blood

volume, while also increased potassium secretion in urine.


How can hyperkalemia lead to cardiac arrest? - 🧠ANSWER ✔✔Normal

levels of potassium are between 3.5 and 5.2 mEq/dL. Hyperkalemia refers

to potassium levels higher that 5.2 mEq/dL.




A major function of potassium is to conduct nerve impulses in muscles. Too

low and muscle weakness occurs and too much can cause muscle

spasms.




This is especially dangerous in the heart muscle and an irregular heartbeat

can cause a heart attack

The body uses the Protein Buffering System, Phosphate Buffering System,

and Carbonic Acid-Bicarbonate System to regulate and maintain

homeostatic pH, what is the consequence of a pH imbalance - 🧠ANSWER

✔✔Proteins contain many acidic and basic group that can be affected by




COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
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, pH changes. Any increase or decrease in blood pH can alter the structure

of the protein (denature), thereby affecting its function as well

Describe the laboratory findings associated with metabolic acidosis,

metabolic alkalosis, respiratory acidosis and respiratory alkalosis. (ie

relative pH and CO2 levels). - 🧠ANSWER ✔✔Normal ABGs (Arterial Blood

Gases) Blood pH: 7.35-7.45 PCO2: 35-45 mm Hg PO2: 90-100 mm Hg

HCO3-: 22-26 mEq/L SaO2: 95-100%




Respiratory acidosis and alkalosis are marked by changes in PCO2. Higher

= acidosis and lower = alkalosis




Metabolic acidosis and alkalosis are caused by something other than

abnormal CO2 levels. This could include toxicity, diabetes, renal failure or

excessive GI losses.




Here are the rules to follow to determine if is respiratory or metabolic in

nature. -If pH and PCO2 are moving in opposite directions, then it is the

pCO2 levels that are causing the imbalance and it is respiratory in nature.

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