CERTIFICATE | 160 QUESTIONS | WITH
COMPLETE SOLUTIONS 2025/26.
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Anthracycline antitumor abx work by:
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Interfering with enzymes
necessary for DNA to replicate in Disrupting energy production in
ALL phases of the mitochondria
cell cycle
Inhibiting cell membrane function
, Blocking protein synthesis in the G1
phase
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mAbs ending in "-ximab" source
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Fully human Chimeric human-mouse
Murine MAbs
mouse
Cancer vaccines
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mAbs ending in "-zumab" source
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Monoclonal
Humanized mouse antibodies Cytokines
, Cancer vaccines Fully human
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These agents are typically categorized as highly emetogenic:
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Anthracyclines 1. Alkylating agents
Non-anthracyclines 2.Nitrosoureas
Cells 1. EGFR inhibitor therapies
with high division rates
2. Antimetabolites
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Immunotherapy works by the following 3 ways:
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Prevent cancer cells from turning off T cells --> allows T cells to infiltrate a tumor
and stop it from growing
, 1. Nitrogen mustards
2.Platinum-based agents (do not possess an alkyl group but still termed
alkylating agents as they work similarly)
3. Nitrosoureas
Passive
Aggressive
Specific
Nonspecifi
c
1. Stopping or slowing the growth of cancer cells
2.Stopping cancer cells from spreading to other parts of the body
3. Helping the immune system recognize cancer cells and increase
its effectiveness at eliminating cancer cells
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Examples of specific immunotherapy
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Humanized mAbs
mouse
Cancer vaccines
Naked mAbs
Corticosteroids
Conjugated monoclonal antibodies
Bispecific monoclonal antibodies