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how do antibiotic drugs work against bacteria? - 🧠 ANSWER ✔✔cell wall
synthesis, cell membrane permeability, protein synthesis (lethal), nonlethal
inhibitors of protein synthesis, synthesis of nucleic acids, antimetabolites,
viral enzyme inhibitors
how do antibiotics have selective toxicity? - 🧠 ANSWER ✔✔toxic to
microbes but harmless to host, disruption of the bacterial cell wall, inhibition
of an enzyme unique to bacteria, disruption of bacterial protein synthesis
what microorganisms have a significant antibiotic resistance? - 🧠 ANSWER
✔✔Enterococcus faecium, Staphylococcus aureus, Enterobacter species,
Klebsiella species, Pseudomonas aeruginosa, Acinetobacter baumannii,
Clostridium difficile
,what are the mechanisms of antibiotic resistance? - 🧠 ANSWER ✔✔-
Enzymatic destruction of drug
- Prevention of penetration of drug
- Alteration of drug's target site
- Rapid ejection of the drug
how to delay emergence of drug resistance - 🧠 ANSWER ✔✔Treat
infection, not contamination
Treat infection, not colonization
Know when to say "No to vanco"
Stop treatment when infection is cured or unlikely
Isolate the pathogen
Break the chain of contagion
Vaccinate
Get the catheters out
Target the pathogen
Access the experts
,Practice antimicrobial control
Use local data
what factors contribute to the selection of antibiotics? - 🧠 ANSWER
✔✔Identify organism
Drug sensitivity of organism
Host factors
Host defenses
Site of infection
Age
Pregnancy and lactation
Previous allergic reactions
Genetic factors
why do patients need to complete the antibiotic they are taking? - 🧠
ANSWER ✔✔can lead to a drug resistant bacteria
susceptible - 🧠 ANSWER ✔✔indicates that the pathogen is likely to be
inhibited if the antimicrobial compound in the blood reaches the
concentration usually achievable
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, intermediate - 🧠 ANSWER ✔✔indicates that the results should be
considered equivocal, and if the microorganism is not fully susceptible to
alternative, clinically feasible drugs, the test should be repeated. This
category implies possible clinical applicability in body sites where the drug
is physiologically concentrated or in situations where high dosage of drug
can be used
resistant - 🧠 ANSWER ✔✔indicates that the pathogen is not likely to be
inhibited if the antimicrobial compound in the blood reaches the
concentration usually achievable; other therapy should be considered
penicillin mechanism of action - 🧠 ANSWER ✔✔weaken the cell wall,
causing bacteria to take up excessive water and rupture, active only
against bacteria that are undergoing growth and division, bactericidal
beta lactam antibiotics - 🧠 ANSWER ✔✔contain a β-lactam ring, ex.
penicillin and cephalosporins;
β-lactam ring of antibiotic fits into bacterial cell wall and inhibits
transpeptidation, bacteria will eventually rupture because the unsupported
cell wall cannot withstand its growth