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Comprehensive PN Adult Medical-Surgical Content
Mastery Series (CMS) Exam 2025 – ATI Practice Test,
Study Guide, and Rationales
Prepare for the Comprehensive PN Adult Medical-Surgical CMS Exam 2025 with this ATI-
style study guide and practice test. Covers adult health, nursing interventions, clinical
reasoning, disease management, and pharmacology to help you master PN medical-surgical
concepts and boost your NCLEX readiness.
• PN Adult Medical-Surgical CMS Exam
• ATI Comprehensive PN CMS
• PN Med-Surg Content Mastery Series
• ATI PN practice test
A nurse in a long-term care unit is assisting in the care of a client who has Alzheimer's disease. Which of
the following actions should the nurse take?
A. Alternate the client's daily routine
B. Keep the lights dimmed.
C. Raise the four side rails on the client's bed.
D. Participate in reminiscence therapy with the client. - ANSWER-D. Participate in reminiscence therapy
with the client.
TEST
A nurse is reinforcing teaching with a client who is taking oxybutynin. The nurse should tell the client
that the medication will have which of the following effects?
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a) Relaxes the muscles of the bladder
b) Increases venous return to the heart
c) Relaxes the muscles of the colon
d) Increases tissue perfusion in the lungs - ANSWER-A. Relaxes the muscles of the bladder.
Rationale:
Oxybutynin relaxes the bladder muscles to decrease the urge of constant urination.
Option B does not increase or promote venous return.
Option C the bladder is the target organ not the colon.
Option D not associated with increased blood flow and perfusion to lungs.
TEST
A nurse is reviewing the laboratory report of a client who has cancer and is experiencing anorexia. Which
of the following laboratory values should indicate to the nurse that the client is experiencing
malnutrition?
a) Prealbumin 10.5 mg/dL
b) Hematocrit 45%
c) WBC count 6,000/mm3
d) BUN 15 mg/dL - ANSWER-A. Prealbumin 10.5 mg/dL
Rationale:
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Prealbumin normal range is 15-36mg/dL. Prealbumin helps in the thyroid hormone and Vitamin A
circulation in our bloodstream. It also helps in regulation of how the body uses energy. Below normal
prealbumin is indicative of malnutrition.
A nurse is reinforcing teaching about immunizations with an older adult client. Which of the following
instructions should the nurse include?
a) "You should receive the live, attenuated influenza vaccine every other year."
b) "You should receive the hepatitis A vaccine
every 10 years."
c) "You should receive the human
papillomavirus vaccine."
d) "You should receive one dose of the pneumococcal vaccine." - ANSWER-D. "You should receive one
dose of the pneumococcal vaccine."
Rationale:
One dose Pneumococcal vaccine is given to elderly 65 yrs old above. Influenza vaccine is given annually
to this age group. HPV is given to women in reproductive age.
TEST
A nurse is monitoring a client who is receiving a transfusion of packed RBCs. Which of the following
findings should the nurse identify as an indication that the client should receive diphenhydramine?
a) Pulmonary congestion
b) Urticaria
c) Vomiting
d) Jugular vein distention - ANSWER-B. Urticaria
Rationale:
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Acute hypersensitivity reaction following blood transfusion includes symptoms of localized pruritus and
urticaria unrelated to infusion site. Diphenhydramine is an antihistamine use to treat hypersensitivity or
allergic reaction.
TEST
A nurse is caring for a client who is expecting a generalized tonic-clonic seizure. Which of the following
actions should the nurse take?
a) Apply restraints to the client.
b) Insert a tongue blade into the client's mouth.
c) Administer an IV bolus of lorazepam.
d) Place the client in the prone position. - ANSWER-c) Administer an IV bolus of lorazepam
Rationale:
Administering an IV bolus of lorazepam is the appropriate action for a patient who is expecting a
generalized tonic-clonic seizure, as it can help prevent or reduce the severity of the seizure.
TEST
A nurse is prioritizing care for four clients following a change-of-shift report. Which of the following
clients should the nurse attend to first?
a) A client who has diverticulitis and a
temperature of 38.3C (100.9F)
b) A client who has a prescription for a sputum
specimen to be obtained before breakfast
c) A client who sustained a head injury 2 days
ago and has a decreased level of
consciousness
d) A client who has Alzheimer's disease and
Comprehensive PN Adult Medical-Surgical Content
Mastery Series (CMS) Exam 2025 – ATI Practice Test,
Study Guide, and Rationales
Prepare for the Comprehensive PN Adult Medical-Surgical CMS Exam 2025 with this ATI-
style study guide and practice test. Covers adult health, nursing interventions, clinical
reasoning, disease management, and pharmacology to help you master PN medical-surgical
concepts and boost your NCLEX readiness.
• PN Adult Medical-Surgical CMS Exam
• ATI Comprehensive PN CMS
• PN Med-Surg Content Mastery Series
• ATI PN practice test
A nurse in a long-term care unit is assisting in the care of a client who has Alzheimer's disease. Which of
the following actions should the nurse take?
A. Alternate the client's daily routine
B. Keep the lights dimmed.
C. Raise the four side rails on the client's bed.
D. Participate in reminiscence therapy with the client. - ANSWER-D. Participate in reminiscence therapy
with the client.
TEST
A nurse is reinforcing teaching with a client who is taking oxybutynin. The nurse should tell the client
that the medication will have which of the following effects?
,2|Page
a) Relaxes the muscles of the bladder
b) Increases venous return to the heart
c) Relaxes the muscles of the colon
d) Increases tissue perfusion in the lungs - ANSWER-A. Relaxes the muscles of the bladder.
Rationale:
Oxybutynin relaxes the bladder muscles to decrease the urge of constant urination.
Option B does not increase or promote venous return.
Option C the bladder is the target organ not the colon.
Option D not associated with increased blood flow and perfusion to lungs.
TEST
A nurse is reviewing the laboratory report of a client who has cancer and is experiencing anorexia. Which
of the following laboratory values should indicate to the nurse that the client is experiencing
malnutrition?
a) Prealbumin 10.5 mg/dL
b) Hematocrit 45%
c) WBC count 6,000/mm3
d) BUN 15 mg/dL - ANSWER-A. Prealbumin 10.5 mg/dL
Rationale:
,3|Page
Prealbumin normal range is 15-36mg/dL. Prealbumin helps in the thyroid hormone and Vitamin A
circulation in our bloodstream. It also helps in regulation of how the body uses energy. Below normal
prealbumin is indicative of malnutrition.
A nurse is reinforcing teaching about immunizations with an older adult client. Which of the following
instructions should the nurse include?
a) "You should receive the live, attenuated influenza vaccine every other year."
b) "You should receive the hepatitis A vaccine
every 10 years."
c) "You should receive the human
papillomavirus vaccine."
d) "You should receive one dose of the pneumococcal vaccine." - ANSWER-D. "You should receive one
dose of the pneumococcal vaccine."
Rationale:
One dose Pneumococcal vaccine is given to elderly 65 yrs old above. Influenza vaccine is given annually
to this age group. HPV is given to women in reproductive age.
TEST
A nurse is monitoring a client who is receiving a transfusion of packed RBCs. Which of the following
findings should the nurse identify as an indication that the client should receive diphenhydramine?
a) Pulmonary congestion
b) Urticaria
c) Vomiting
d) Jugular vein distention - ANSWER-B. Urticaria
Rationale:
, 4|Page
Acute hypersensitivity reaction following blood transfusion includes symptoms of localized pruritus and
urticaria unrelated to infusion site. Diphenhydramine is an antihistamine use to treat hypersensitivity or
allergic reaction.
TEST
A nurse is caring for a client who is expecting a generalized tonic-clonic seizure. Which of the following
actions should the nurse take?
a) Apply restraints to the client.
b) Insert a tongue blade into the client's mouth.
c) Administer an IV bolus of lorazepam.
d) Place the client in the prone position. - ANSWER-c) Administer an IV bolus of lorazepam
Rationale:
Administering an IV bolus of lorazepam is the appropriate action for a patient who is expecting a
generalized tonic-clonic seizure, as it can help prevent or reduce the severity of the seizure.
TEST
A nurse is prioritizing care for four clients following a change-of-shift report. Which of the following
clients should the nurse attend to first?
a) A client who has diverticulitis and a
temperature of 38.3C (100.9F)
b) A client who has a prescription for a sputum
specimen to be obtained before breakfast
c) A client who sustained a head injury 2 days
ago and has a decreased level of
consciousness
d) A client who has Alzheimer's disease and
