ROLE OF THE (MICROBIOTA-) GUT-BRAIN AXIS IN FUNCTIONAL GASTROINTESTINAL,
FOOD INTAKE AND AFFECTIVE DISORDERS
ANATOMY & PHYSIOLOGY OF THE “(MICROBIOTA-) BRAIN-GUT AXIS”
Gastrointestinal (GI) tract: (Microbiota)-Gut-Brain Axis:
Communication between brain and gastrointestinal tract à 2 ways of communication:
- Systemic: through
bloodstream, circulation
- Neural route
à Bidirectional communication
systems
Enteric Nervous System (ENS)
(afbeelding rechts):
Lumen: where food passes by,
where microbiota are
1
,Autonomic Nervous System (ANS):
Hypothalamo-Pituitary-Adrenal (HPA) axis:
- CRH
o hypothalamus → pituitary → ACTH
o hypothalamus → ANS outflow
o CRH in GI tract
- ACTH
o pituitary → adrenal cortex → cortisol
- cortisol
o negative feedback hypothalamus
o effects on body
à Chronic activation à negative effects
2
, HPA axis:
CRH w ook veel aangemaakt in GI tract zelf
CRH2: dampening effect on most systems
à Balance between the 2
Vagal anti-inflammatory pathway:
Altijd eten in GI, bevat bacterieën
à Door nervus vagus signalen naar brein
à brain influences degree of
inflammation in respons to food stimuli
FUNCTIONAL GASTROINTESTINAL DISORDERS: DEFINITIONS & EPIDEMIOLOGY
(unexplained) gastrointestinal symptoms
à magnitude of the problem
62% à groot problem
Huisartsen zien veel GI problemen, maar veel
blijven onverklaard
3
FOOD INTAKE AND AFFECTIVE DISORDERS
ANATOMY & PHYSIOLOGY OF THE “(MICROBIOTA-) BRAIN-GUT AXIS”
Gastrointestinal (GI) tract: (Microbiota)-Gut-Brain Axis:
Communication between brain and gastrointestinal tract à 2 ways of communication:
- Systemic: through
bloodstream, circulation
- Neural route
à Bidirectional communication
systems
Enteric Nervous System (ENS)
(afbeelding rechts):
Lumen: where food passes by,
where microbiota are
1
,Autonomic Nervous System (ANS):
Hypothalamo-Pituitary-Adrenal (HPA) axis:
- CRH
o hypothalamus → pituitary → ACTH
o hypothalamus → ANS outflow
o CRH in GI tract
- ACTH
o pituitary → adrenal cortex → cortisol
- cortisol
o negative feedback hypothalamus
o effects on body
à Chronic activation à negative effects
2
, HPA axis:
CRH w ook veel aangemaakt in GI tract zelf
CRH2: dampening effect on most systems
à Balance between the 2
Vagal anti-inflammatory pathway:
Altijd eten in GI, bevat bacterieën
à Door nervus vagus signalen naar brein
à brain influences degree of
inflammation in respons to food stimuli
FUNCTIONAL GASTROINTESTINAL DISORDERS: DEFINITIONS & EPIDEMIOLOGY
(unexplained) gastrointestinal symptoms
à magnitude of the problem
62% à groot problem
Huisartsen zien veel GI problemen, maar veel
blijven onverklaard
3
