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A Level Biology: Primary Non-Specific Defences against Pathogens Exam

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Give three examples of exchange surfaces that are thinner and less protected from infection - answer-air ways, lungs, digestive system What physical non-specific defence protects epithelial cells on exchange surfaces from pathogens? - answer-mucous membranes What cells produce mucus? - answer-goblet cells Where are mucous producing glands found? - answer-under the epithelium What two things does mucous contain that removes pathogens? - answer-lysozymes and phagocytes What is the role of lysozymes in mucus? - answer-to break down bacterial and fungal cell walls What is the role of cilia in the mucociliary escalator ? - answer-to waft mucous along the top of the trachea where it can be swallowed How is the stomach involved in the mucociliary escalator? - answer-pathogens are killed by the acidity of the stomach as the low pH denatures pathogen's enzymes Give 4 examples of when mucous membranes are found in the body other than the trachea - answer-nose, ear, anus, genitals Give three examples of expulsive reflexes - answer-coughing, sneezing, vomiting What is the role of expulsive reflexes? - answer-to expel pathogens from the body Give four symptoms of inflammation - answer-redness, swelling, heat, pain What cells detect microorganisms entering the body which release histamine which thus causes inflammation? - answer-mast cells What cell signalling substance do mast cells produce that causes inflammation? - answer-histamine What effect does histamine have that causes inflammation? - answer-vasodilation of arterioles and increased permeability of capillary walls that allows blood plasma and phagocytic white blood cells to enter tissue fluid What is another term for swelling? - answer-oedema What is the result of increased phagocytes and blood plasma entering tissue fluid during inflammation? - answer-swelling

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A Level Biology: Primary Non-Specific
Defences against Pathogens Exam
With answers

Give four examples of primary non-specific defences against pathogens in animals - answer-
skin, blood clotting, mucous, expulsive reflexes

What is the outer layer of skin called? - answer-epidermis

What are keratinocytes? - answer-epidermal cells that produce keratin

What % of cells in the epidermis are keratinocytes? - answer-90%

How and where are keratinocytes produced? - answer-by mitosis at the base of the epidermis

True or false: keratinocytes migrate out to the skins surface but die by the time they get there -
answer-true

What is the process called whereby the cytoplasm of keratinocytes dries out and replaced by
keratin-causing the cells to die? - answer-keratinisation

What protein is exposed when damage to a blood vessel occurs? - answer-collagen

What does exposed collagen from the vessel wall cause platelets to do? - answer-attract to the
collagen and become active platelets

Give the equation that produces thrombin enzymes - answer-thromboplastin -> prothrombin ->
thrombin

What two substances aid the production of prothrombin from thrombin? - answer-vitamin k and
calcium

What reaction does the thrombin enzyme catalyse? - answer-the formation of insoluble fibrin
from soluble fibrinogen

What is the function of fibrin in a blood clot? - answer-it creates fibres to hold a scab together

What three substances make up a scab? - answer-fibrin, platelets, red blood cells

What are the four steps when repairing skin under a scab? - answer-a deposition of fibrous
collagen is created, stem cells divide by mitosis to form new cells and migrate to the edges of
the cut to differentiate, new blood vessels grow and the tissue contracts to draw the edges of
the cut together and the scab is released

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