NUR-641E Advanced Pathophysiology and
Pharmacology for the Nurse Educator Exam
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Terms in this set (210)
Involves ADME (absorption, distribution, metabolism
and elimination).
Absorption: absorption from the administration site
either directly or indirectly into the blood/plasma.
Distribution: reversibly or irreversibly move from the
Pharmacokinetics
bloodstream into the interstitial and intracellular fluid.
Metabolism: bio-transformed via hepatic metabolism
or by other tissues.
Elimination: lastly, the drug & its metabolites are
eliminated from the body
The route of Intravenous; putting entire dose into a patient's vein
administration with the and bypassing absorption. Intravenous route avoids
highest bio-availability is first-pass metabolism in the liver.
rectal administration variable and erratic absorption
disadvantages
Steady state (SS) is usually reached within 4-5 half-lives of a drug
, The half-life of a drug is how long it takes for half the drug to be excreted
defined as from the body
Half-life of a drug Drug administration frequently
determines:
Predicts: How long toxic effects can last
First-order pharmacokinetics of a drug
Half-life is constant with: Zero-order (nonlinear) pharmacokinetics means a
drug is metabolized at a constant rate per unit time,
independent of the concentration.
May have enhanced activity if any CYP3A4 inducer
CYP3A4 substrate drugs
drugs are used along with it.
Discovery: laboratory research to develop the new
drug
Pre-clinical research with animal testing for safety
(Phase I)
Clinical research on human subjects for medication
safety (Phase II)
Drug development steps
(according to the FDA)
Clinical research in humans comparing the new drug
to accepted medications or placebo depending on
the study (Phase III)
FDA review of the results to determine approval
Post-marketing study to identify adverse effects not
found in earlier clinical studies (Phase IV)
Pharmacology for the Nurse Educator Exam
Questions and Answers (Verified Answers) (Latest
Update 2025) UPDATE!!
Save
Terms in this set (210)
Involves ADME (absorption, distribution, metabolism
and elimination).
Absorption: absorption from the administration site
either directly or indirectly into the blood/plasma.
Distribution: reversibly or irreversibly move from the
Pharmacokinetics
bloodstream into the interstitial and intracellular fluid.
Metabolism: bio-transformed via hepatic metabolism
or by other tissues.
Elimination: lastly, the drug & its metabolites are
eliminated from the body
The route of Intravenous; putting entire dose into a patient's vein
administration with the and bypassing absorption. Intravenous route avoids
highest bio-availability is first-pass metabolism in the liver.
rectal administration variable and erratic absorption
disadvantages
Steady state (SS) is usually reached within 4-5 half-lives of a drug
, The half-life of a drug is how long it takes for half the drug to be excreted
defined as from the body
Half-life of a drug Drug administration frequently
determines:
Predicts: How long toxic effects can last
First-order pharmacokinetics of a drug
Half-life is constant with: Zero-order (nonlinear) pharmacokinetics means a
drug is metabolized at a constant rate per unit time,
independent of the concentration.
May have enhanced activity if any CYP3A4 inducer
CYP3A4 substrate drugs
drugs are used along with it.
Discovery: laboratory research to develop the new
drug
Pre-clinical research with animal testing for safety
(Phase I)
Clinical research on human subjects for medication
safety (Phase II)
Drug development steps
(according to the FDA)
Clinical research in humans comparing the new drug
to accepted medications or placebo depending on
the study (Phase III)
FDA review of the results to determine approval
Post-marketing study to identify adverse effects not
found in earlier clinical studies (Phase IV)
