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Advanced Pharmacology Nurs 5334 UT Arlington
Week 7 Endocrine Drugs Mini Quiz Questions and
Answers
Beta lactamase inhibitors - ...ANSWER...✓✓ Clavulanic
acid, sublactam, taxobactam
Unasyn - ...ANSWER...✓✓ Ampicillin and sulbactam
Augmentin - ...ANSWER...✓✓ Amoxicillin clavulanic acid
Hapten - ...ANSWER...✓✓ Drug +plasma protein severe
allergic reaction
Mechanisms resistance to beta lactamase -
...ANSWER...✓✓ Inactivation by beta lactamase, mutation
trans peptidase target, impaired penetration of drug into
organism, drug effluent pumps
MRSA - ...ANSWER...✓✓ Resistant organisms produce
PBPs with decreased affinity for binding beta lactam
antibiotics
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Impaired penetration of drug into organosm -
...ANSWER...✓✓ Absence of porins or down regulation of
porins or porins smaller
Drug efflux pumps - ...ANSWER...✓✓ Nonspecific, spit out
whatever bacteria doesn't need, major mechanism MDR
Prevention of resistance steains - ...ANSWER...✓✓
Testing, choose right antibiotic, complete course therapy,
don't use antibiotic when not indicated
Mutidrug resistant organisms - ...ANSWER...✓✓
Organisms that are resistant to 1 or more class of
organisms. Drug efflux pumps
Penicillin - ...ANSWER...✓✓ Bactericidal
Penicillin adverse effects - ...ANSWER...✓✓ GI distress,
oral/vaginal candidiasis, rash, anaphylaxis
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Cephalosporins - ...ANSWER...✓✓ More stable against
beta lactamases, increased range activity
1st generation cephalosporin - ...ANSWER...✓✓ Cefazolin,
cephalexin
G+, susceptible beta lactamase
2,3 generations cephalosporins - ...ANSWER...✓✓
Broader spectrum,
Increase resistance beta lactamase, increase half life,
some cross BBB
4,5 generations cephalosporins - ...ANSWER...✓✓
Cefepine, excellent resistance most beta lactamase,
excellent CNS penetration, ceftaroline against MRSA
Adverse reactions cephalosporins - ...ANSWER...✓✓
Hypersensitivity, fever, skin rashes, nephritis,
granulocytopenia, hemolytic anemia, anorexia
Cefotetan - ...ANSWER...✓✓ Avoid ETOH! Disulfiram like
reaction with this cephalosporins
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Treatment for C diff from broad spectrum cephalosporin -
...ANSWER...✓✓ Vancomycin, metrondiszole
Example monobactam - ...ANSWER...✓✓ Aztreonam
IV or IM
Active against G neg only
Tolerated by PCN allergic patiemts
Example carbapenem - ...ANSWER...✓✓ Imipenem, IV or
IM only
Widest spectrum of any beta lactam, must prescribe with
cilastin to inhibit first pass elimination by renal enzyme
dehydropeptidase, low crossreactivity for PCNs. Good for
meningitis, peritonitis in really sick patients
Vancomycin - ...ANSWER...✓✓ Cell wall inhibitor but not
beta lactam, glycopeptide structure, best treatment for
MRSA and G+. Only use Italy to treat antibiotic induced
colitis, C. difficile and staph entericolitis
Must monitor peak and trough, poorly absorbed po
Advanced Pharmacology Nurs 5334 UT Arlington
Week 7 Endocrine Drugs Mini Quiz Questions and
Answers
Beta lactamase inhibitors - ...ANSWER...✓✓ Clavulanic
acid, sublactam, taxobactam
Unasyn - ...ANSWER...✓✓ Ampicillin and sulbactam
Augmentin - ...ANSWER...✓✓ Amoxicillin clavulanic acid
Hapten - ...ANSWER...✓✓ Drug +plasma protein severe
allergic reaction
Mechanisms resistance to beta lactamase -
...ANSWER...✓✓ Inactivation by beta lactamase, mutation
trans peptidase target, impaired penetration of drug into
organism, drug effluent pumps
MRSA - ...ANSWER...✓✓ Resistant organisms produce
PBPs with decreased affinity for binding beta lactam
antibiotics
,2|Page
Impaired penetration of drug into organosm -
...ANSWER...✓✓ Absence of porins or down regulation of
porins or porins smaller
Drug efflux pumps - ...ANSWER...✓✓ Nonspecific, spit out
whatever bacteria doesn't need, major mechanism MDR
Prevention of resistance steains - ...ANSWER...✓✓
Testing, choose right antibiotic, complete course therapy,
don't use antibiotic when not indicated
Mutidrug resistant organisms - ...ANSWER...✓✓
Organisms that are resistant to 1 or more class of
organisms. Drug efflux pumps
Penicillin - ...ANSWER...✓✓ Bactericidal
Penicillin adverse effects - ...ANSWER...✓✓ GI distress,
oral/vaginal candidiasis, rash, anaphylaxis
,3|Page
Cephalosporins - ...ANSWER...✓✓ More stable against
beta lactamases, increased range activity
1st generation cephalosporin - ...ANSWER...✓✓ Cefazolin,
cephalexin
G+, susceptible beta lactamase
2,3 generations cephalosporins - ...ANSWER...✓✓
Broader spectrum,
Increase resistance beta lactamase, increase half life,
some cross BBB
4,5 generations cephalosporins - ...ANSWER...✓✓
Cefepine, excellent resistance most beta lactamase,
excellent CNS penetration, ceftaroline against MRSA
Adverse reactions cephalosporins - ...ANSWER...✓✓
Hypersensitivity, fever, skin rashes, nephritis,
granulocytopenia, hemolytic anemia, anorexia
Cefotetan - ...ANSWER...✓✓ Avoid ETOH! Disulfiram like
reaction with this cephalosporins
, 4|Page
Treatment for C diff from broad spectrum cephalosporin -
...ANSWER...✓✓ Vancomycin, metrondiszole
Example monobactam - ...ANSWER...✓✓ Aztreonam
IV or IM
Active against G neg only
Tolerated by PCN allergic patiemts
Example carbapenem - ...ANSWER...✓✓ Imipenem, IV or
IM only
Widest spectrum of any beta lactam, must prescribe with
cilastin to inhibit first pass elimination by renal enzyme
dehydropeptidase, low crossreactivity for PCNs. Good for
meningitis, peritonitis in really sick patients
Vancomycin - ...ANSWER...✓✓ Cell wall inhibitor but not
beta lactam, glycopeptide structure, best treatment for
MRSA and G+. Only use Italy to treat antibiotic induced
colitis, C. difficile and staph entericolitis
Must monitor peak and trough, poorly absorbed po
