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Certified Histocompatibility Specialist - CHS Exam
2025 Preparation Test Bank With 230 Questions and
Correct Answers/ ASHI CHS Exam Practice Test
Which of the following is not a secondary lymphoid organ?
a. Spleen
b. Thymus
c. Lymph nodes
d. Liver
e. Tonsils - ...ANSWER...✓✓ Thymus
Primary lymphatic organs are where lymphocytes are
formed and mature.
stem cells to divide and mature into B- and T- cells:
There are two primary lymphatic organs: the red bone
marrow and the thymus gland.
Which of the following is not a component of the
reticuloendothelial cell system?
a. Microglial cells
b. Kupffer cells
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c. Langerhans cells
d. Neutrophils
e. Monocytes - ...ANSWER...✓✓ Neutrophils
Macrophages = tissue
Monocytes = blood
Kupffer cells = liver
Microgial cells = nervous system
Langerhans = skin
Not = endothelial cells, fibroblasts, and most leukocytes
Opsonization is a term to describe what?
a. Lysis of bacteria
b. Coating of bacteria
c. Ingestion of bacteria
d. Killing of bacteria
e. Phagocytosis - ...ANSWER...✓✓ Coating of bacteria
Antibody opsonization is the process by which a pathogen
is marked for ingestion and eliminated by a phagocyte.
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Which of the following does not describe a role of
antibodies in host defense?
a. They serve as a bridge between bacteria and
phagocytes
b. They lyse bacteria
c. They enhance complement binding to the bacterial cell
wall
d. They prevent viruses from infecting cells
e. They bind pathogens in mucus secretions -
...ANSWER...✓✓ They lyse bacteria
MHC Class I and II molecules differ in all of the following
except
a. Types of T cells they stimulate
b. Types of cells they are expressed on
c. Which chromosome they are located on
d. Types of antigens they present
e. Whether or not they have foreign peptides in the
antigen-binding groove - ...ANSWER...✓✓ Which
chromosome they are located on
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The primary role of the proteasome in antigen
presentation is to
a. Prevent premature folding of MHC class I molecules
b. Process cytoplasmic proteins
c. Degrade recycled MHC molecules
d. Bind HLA-DM in the endosome
e. Chaperone peptides to the cell surface -
...ANSWER...✓✓ Process cytoplasmic proteins
The main function of the proteasome is to degrade
unneeded or damaged proteins by proteolysis, a chemical
reaction that breaks peptide bonds.
Peptides that bind to MHC class I molecules differ from
peptides that bind to MHC class II molecules in all
except which of the following ways?
a. They are shorter
b. They were processed by different proteases
c. They anchor in the middle instead of the end of the MHC
molecule
Certified Histocompatibility Specialist - CHS Exam
2025 Preparation Test Bank With 230 Questions and
Correct Answers/ ASHI CHS Exam Practice Test
Which of the following is not a secondary lymphoid organ?
a. Spleen
b. Thymus
c. Lymph nodes
d. Liver
e. Tonsils - ...ANSWER...✓✓ Thymus
Primary lymphatic organs are where lymphocytes are
formed and mature.
stem cells to divide and mature into B- and T- cells:
There are two primary lymphatic organs: the red bone
marrow and the thymus gland.
Which of the following is not a component of the
reticuloendothelial cell system?
a. Microglial cells
b. Kupffer cells
,2|Page
c. Langerhans cells
d. Neutrophils
e. Monocytes - ...ANSWER...✓✓ Neutrophils
Macrophages = tissue
Monocytes = blood
Kupffer cells = liver
Microgial cells = nervous system
Langerhans = skin
Not = endothelial cells, fibroblasts, and most leukocytes
Opsonization is a term to describe what?
a. Lysis of bacteria
b. Coating of bacteria
c. Ingestion of bacteria
d. Killing of bacteria
e. Phagocytosis - ...ANSWER...✓✓ Coating of bacteria
Antibody opsonization is the process by which a pathogen
is marked for ingestion and eliminated by a phagocyte.
,3|Page
Which of the following does not describe a role of
antibodies in host defense?
a. They serve as a bridge between bacteria and
phagocytes
b. They lyse bacteria
c. They enhance complement binding to the bacterial cell
wall
d. They prevent viruses from infecting cells
e. They bind pathogens in mucus secretions -
...ANSWER...✓✓ They lyse bacteria
MHC Class I and II molecules differ in all of the following
except
a. Types of T cells they stimulate
b. Types of cells they are expressed on
c. Which chromosome they are located on
d. Types of antigens they present
e. Whether or not they have foreign peptides in the
antigen-binding groove - ...ANSWER...✓✓ Which
chromosome they are located on
, 4|Page
The primary role of the proteasome in antigen
presentation is to
a. Prevent premature folding of MHC class I molecules
b. Process cytoplasmic proteins
c. Degrade recycled MHC molecules
d. Bind HLA-DM in the endosome
e. Chaperone peptides to the cell surface -
...ANSWER...✓✓ Process cytoplasmic proteins
The main function of the proteasome is to degrade
unneeded or damaged proteins by proteolysis, a chemical
reaction that breaks peptide bonds.
Peptides that bind to MHC class I molecules differ from
peptides that bind to MHC class II molecules in all
except which of the following ways?
a. They are shorter
b. They were processed by different proteases
c. They anchor in the middle instead of the end of the MHC
molecule
