Werkgroep module 5
MD-K 5.1 Bloedverlies in de eerste helft van de zwangerschap.............................................. 5
Oorzaken van bloedverlies <16 wk......................................................................................................5
Oorzaken van bloedverlies 16-24 wk................................................................................................. 6
Miskraam (spontane abortus)................................................................................................................ 6
EUG.............................................................................................................................................................. 12
Mola hydatidosa.......................................................................................................................................15
Niet gynaecologische oorzaken blv................................................................................................... 16
Gynaecologische oorzaken blv............................................................................................................16
Werkcollege....................................................................................................................................... 17
MD-K 5.2 afwijkingen placenta vliezen en navelstreng........................................................... 21
Placenta locaties......................................................................................................................................21
Afwijkingen placenta..............................................................................................................................24
Afwijkingen vliezen.................................................................................................................................26
Afwijkingen navelstreng....................................................................................................................... 27
Werkcollege....................................................................................................................................... 27
MD-K 5.3 Bloedverlies in het 2e en 3e trimester....................................................................... 28
Obstetrische oorzaken van bloedverlies >24 weken...................................................................28
● Placenta praevia...................................................................................................................................28
● Abruptio placentae..............................................................................................................................29
● (Gescheurde) vasa praevia................................................................................................................32
● Dreigende vroeggeboorte.................................................................................................................33
● Randvenebloeding.............................................................................................................................. 33
● Placenta circumvallata....................................................................................................................... 33
● Uteruslitteken........................................................................................................................................34
Werkcollege....................................................................................................................................... 36
MD-K 5.4 Oligo en polyhydramnion..............................................................................................38
Vruchtwater...............................................................................................................................................38
Embryologie nieren.................................................................................................................................39
● Polyhydramnion................................................................................................................................... 42
Polyhydramnion door infectie..............................................................................................................43
Polyhydramnion door rhesusincompabiliteit.................................................................................. 43
● Oligohydramnion................................................................................................................................. 44
● Potter sequentie......................................................................................................................................1
● Oligohydramion door TTST twin to twin transfusion syndrome............................................ 1
● Oligohydramnion door ACE remmers of NSAID’s.......................................................................1
, Werkcollege..........................................................................................................................................1
MD-K 5.5 Caput beweeglijk op bekkeningang..............................................................................1
Prevalentie....................................................................................................................................................1
Oorzaak..........................................................................................................................................................1
Diagnostiek.................................................................................................................................................. 1
Gevolgen.......................................................................................................................................................1
Beleid............................................................................................................................................................. 1
MD-K 5.6 Schildklieraandoeningen................................................................................................. 1
Fysiologie schildklier.................................................................................................................................1
Hyperthyroïdie............................................................................................................................................ 1
Hypothyroidie.............................................................................................................................................. 1
Fysiologie schildklier zwangerschap................................................................................................... 1
Schildklier aandoeningen en zwanger................................................................................................ 1
Hyperthyroidie in de zwangerschap.................................................................................................... 1
Hypothyreoïdie en zwangerschap........................................................................................................ 1
Postpartum thyroiditis.............................................................................................................................. 1
Werkcollege..........................................................................................................................................1
MD-K 5.7 Hemoglobinopathieën...................................................................................................... 1
Erytropoëse..................................................................................................................................................1
Sikkelcelanemie.......................................................................................................................................... 1
Sikkelcelanemie verloskunde................................................................................................................. 1
Thalassemie.................................................................................................................................................1
Laboratoriumonderzoek anemie............................................................................................................1
Screening HbP’s......................................................................................................................................... 1
Werkcollege..........................................................................................................................................1
MD-K 5.8 Tractus uropoeticus...........................................................................................................1
Anatomie TU................................................................................................................................................1
Urineproductie.............................................................................................................................................1
Glomerulaire filtratie................................................................................................................................. 1
Glomerulaire filtratie druk....................................................................................................................... 1
Tubulaire reabsorbtie................................................................................................................................ 1
Reabsorbtieproces..................................................................................................................................... 1
Tubulaire secretie....................................................................................................................................... 1
Na+ en waterhuishouding....................................................................................................................... 1
RAAS systeem............................................................................................................................................ 1
Atriaal natriuretische peptide.................................................................................................................1
Osmoregulatie: regulatie van water.................................................................................................... 1
Regulatie van calcium...............................................................................................................................1
, Zuur base evenwicht................................................................................................................................. 1
Endocriene functies................................................................................................................................... 1
Werkcollege.................................................................................................................................................1
MD-K 5.9 Aandoeningen tractus uropoeticus............................................................................... 1
Hydronefrose...............................................................................................................................................1
Nierstuwing..................................................................................................................................................1
UWI.................................................................................................................................................................1
Nierstenen.................................................................................................................................................... 1
Urine retentie/ retentieblaas...................................................................................................................1
Urine incontinentie.....................................................................................................................................1
Nefrotisch syndroom.................................................................................................................................1
Werkcollege..........................................................................................................................................1
MD-K 5.10 Tensieregulatie................................................................................................................ 1
Tensieregulatie............................................................................................................................................1
Zenuwstelsel en bloedvaten.................................................................................................................. 1
RAAS systeem............................................................................................................................................ 1
MD-K 5.11 Hypertensieve aandoeningen.......................................................................................1
Pathofysiologie........................................................................................................................................... 1
Screening...................................................................................................................................................... 1
Preventie....................................................................................................................................................... 1
Diagnostiek.................................................................................................................................................. 1
Monitoring.................................................................................................................................................... 1
Behandeling.................................................................................................................................................1
Postpartum en toekomst......................................................................................................................... 1
Werkcollege..........................................................................................................................................1
MD-K 5.12 Hemostase........................................................................................................................ 1
Bloeding........................................................................................................................................................ 1
Hemostase................................................................................................................................................... 1
Cascades....................................................................................................................................................... 1
Antistolling...................................................................................................................................................1
Vitamine K.................................................................................................................................................... 1
Veranderingen zwangerschap............................................................................................................... 1
MD-K 5.13 Bloedgroepimmunisatie................................................................................................ 1
Bloedgroepsystemen................................................................................................................................ 1
Bloedgroep antagonisme........................................................................................................................ 1
Gevolgen IEA............................................................................................................................................... 1
Diagnostiek.................................................................................................................................................. 1
Behandeling.................................................................................................................................................1
, Screening...................................................................................................................................................... 1
Preventie....................................................................................................................................................... 1
Trombocytenimmunisatie........................................................................................................................ 1
Werkcollege..........................................................................................................................................1
MD-K 5.14 Neonatale problematiek................................................................................................ 1
Enterohepatische kringloop....................................................................................................................1
Neonatale enterohepatische kringloop...............................................................................................1
Bilirubine en icterus...................................................................................................................................1
Hyperbilirubinemie.................................................................................................................................... 1
Pathologische icterus................................................................................................................................1
Polycytemie..................................................................................................................................................1
MD-K 5.15 Psychologie.......................................................................................................................1
MD-K 5.16 Seksualiteit....................................................................................................................... 1
Seksuele disfuncties..................................................................................................................................1
Werkcollege..........................................................................................................................................1
MD-K 5.1 Bloedverlies in de eerste helft van de zwangerschap.............................................. 5
Oorzaken van bloedverlies <16 wk......................................................................................................5
Oorzaken van bloedverlies 16-24 wk................................................................................................. 6
Miskraam (spontane abortus)................................................................................................................ 6
EUG.............................................................................................................................................................. 12
Mola hydatidosa.......................................................................................................................................15
Niet gynaecologische oorzaken blv................................................................................................... 16
Gynaecologische oorzaken blv............................................................................................................16
Werkcollege....................................................................................................................................... 17
MD-K 5.2 afwijkingen placenta vliezen en navelstreng........................................................... 21
Placenta locaties......................................................................................................................................21
Afwijkingen placenta..............................................................................................................................24
Afwijkingen vliezen.................................................................................................................................26
Afwijkingen navelstreng....................................................................................................................... 27
Werkcollege....................................................................................................................................... 27
MD-K 5.3 Bloedverlies in het 2e en 3e trimester....................................................................... 28
Obstetrische oorzaken van bloedverlies >24 weken...................................................................28
● Placenta praevia...................................................................................................................................28
● Abruptio placentae..............................................................................................................................29
● (Gescheurde) vasa praevia................................................................................................................32
● Dreigende vroeggeboorte.................................................................................................................33
● Randvenebloeding.............................................................................................................................. 33
● Placenta circumvallata....................................................................................................................... 33
● Uteruslitteken........................................................................................................................................34
Werkcollege....................................................................................................................................... 36
MD-K 5.4 Oligo en polyhydramnion..............................................................................................38
Vruchtwater...............................................................................................................................................38
Embryologie nieren.................................................................................................................................39
● Polyhydramnion................................................................................................................................... 42
Polyhydramnion door infectie..............................................................................................................43
Polyhydramnion door rhesusincompabiliteit.................................................................................. 43
● Oligohydramnion................................................................................................................................. 44
● Potter sequentie......................................................................................................................................1
● Oligohydramion door TTST twin to twin transfusion syndrome............................................ 1
● Oligohydramnion door ACE remmers of NSAID’s.......................................................................1
, Werkcollege..........................................................................................................................................1
MD-K 5.5 Caput beweeglijk op bekkeningang..............................................................................1
Prevalentie....................................................................................................................................................1
Oorzaak..........................................................................................................................................................1
Diagnostiek.................................................................................................................................................. 1
Gevolgen.......................................................................................................................................................1
Beleid............................................................................................................................................................. 1
MD-K 5.6 Schildklieraandoeningen................................................................................................. 1
Fysiologie schildklier.................................................................................................................................1
Hyperthyroïdie............................................................................................................................................ 1
Hypothyroidie.............................................................................................................................................. 1
Fysiologie schildklier zwangerschap................................................................................................... 1
Schildklier aandoeningen en zwanger................................................................................................ 1
Hyperthyroidie in de zwangerschap.................................................................................................... 1
Hypothyreoïdie en zwangerschap........................................................................................................ 1
Postpartum thyroiditis.............................................................................................................................. 1
Werkcollege..........................................................................................................................................1
MD-K 5.7 Hemoglobinopathieën...................................................................................................... 1
Erytropoëse..................................................................................................................................................1
Sikkelcelanemie.......................................................................................................................................... 1
Sikkelcelanemie verloskunde................................................................................................................. 1
Thalassemie.................................................................................................................................................1
Laboratoriumonderzoek anemie............................................................................................................1
Screening HbP’s......................................................................................................................................... 1
Werkcollege..........................................................................................................................................1
MD-K 5.8 Tractus uropoeticus...........................................................................................................1
Anatomie TU................................................................................................................................................1
Urineproductie.............................................................................................................................................1
Glomerulaire filtratie................................................................................................................................. 1
Glomerulaire filtratie druk....................................................................................................................... 1
Tubulaire reabsorbtie................................................................................................................................ 1
Reabsorbtieproces..................................................................................................................................... 1
Tubulaire secretie....................................................................................................................................... 1
Na+ en waterhuishouding....................................................................................................................... 1
RAAS systeem............................................................................................................................................ 1
Atriaal natriuretische peptide.................................................................................................................1
Osmoregulatie: regulatie van water.................................................................................................... 1
Regulatie van calcium...............................................................................................................................1
, Zuur base evenwicht................................................................................................................................. 1
Endocriene functies................................................................................................................................... 1
Werkcollege.................................................................................................................................................1
MD-K 5.9 Aandoeningen tractus uropoeticus............................................................................... 1
Hydronefrose...............................................................................................................................................1
Nierstuwing..................................................................................................................................................1
UWI.................................................................................................................................................................1
Nierstenen.................................................................................................................................................... 1
Urine retentie/ retentieblaas...................................................................................................................1
Urine incontinentie.....................................................................................................................................1
Nefrotisch syndroom.................................................................................................................................1
Werkcollege..........................................................................................................................................1
MD-K 5.10 Tensieregulatie................................................................................................................ 1
Tensieregulatie............................................................................................................................................1
Zenuwstelsel en bloedvaten.................................................................................................................. 1
RAAS systeem............................................................................................................................................ 1
MD-K 5.11 Hypertensieve aandoeningen.......................................................................................1
Pathofysiologie........................................................................................................................................... 1
Screening...................................................................................................................................................... 1
Preventie....................................................................................................................................................... 1
Diagnostiek.................................................................................................................................................. 1
Monitoring.................................................................................................................................................... 1
Behandeling.................................................................................................................................................1
Postpartum en toekomst......................................................................................................................... 1
Werkcollege..........................................................................................................................................1
MD-K 5.12 Hemostase........................................................................................................................ 1
Bloeding........................................................................................................................................................ 1
Hemostase................................................................................................................................................... 1
Cascades....................................................................................................................................................... 1
Antistolling...................................................................................................................................................1
Vitamine K.................................................................................................................................................... 1
Veranderingen zwangerschap............................................................................................................... 1
MD-K 5.13 Bloedgroepimmunisatie................................................................................................ 1
Bloedgroepsystemen................................................................................................................................ 1
Bloedgroep antagonisme........................................................................................................................ 1
Gevolgen IEA............................................................................................................................................... 1
Diagnostiek.................................................................................................................................................. 1
Behandeling.................................................................................................................................................1
, Screening...................................................................................................................................................... 1
Preventie....................................................................................................................................................... 1
Trombocytenimmunisatie........................................................................................................................ 1
Werkcollege..........................................................................................................................................1
MD-K 5.14 Neonatale problematiek................................................................................................ 1
Enterohepatische kringloop....................................................................................................................1
Neonatale enterohepatische kringloop...............................................................................................1
Bilirubine en icterus...................................................................................................................................1
Hyperbilirubinemie.................................................................................................................................... 1
Pathologische icterus................................................................................................................................1
Polycytemie..................................................................................................................................................1
MD-K 5.15 Psychologie.......................................................................................................................1
MD-K 5.16 Seksualiteit....................................................................................................................... 1
Seksuele disfuncties..................................................................................................................................1
Werkcollege..........................................................................................................................................1
