ANSWERS CURRENTLY TESTING COMPLETE QUESTIONS WITH DETAILED VERIFIED
ANSWERS /ALREADY GRADED A+
MOA of beta-blockers - (ANSWER)Drug class which inhibits the binding of noradrenaline/adrenaline to
beta receptors
Major effects of beta blockers - (ANSWER)-Negatively inotropic (reduces force of contraction)
-Negatively chronotropic (reduces heart rate)
-Reduced juxtaglomerular renin release
-Because of this, it reduces cardiac oxygen consumption
Metoprolol and propanolol - (ANSWER)-Beta receptor antagonists
-extensive first pass metabolism, poor bio-availability
-Lipophilic so can cross blood/brain barrier (e.g. nightmares)
-olol suffix - (ANSWER)Suffix for beta-blockers
Atenolol - (ANSWER)-Beta receptor antagonist
-poor lipid solubility
-longer half life
-doesn't cross blood-brain barrier
Main therapeutic uses of beta blockers - (ANSWER)-cardiac rate control (decreases HR e.g. atrial
fibrillation)
-angina (decreases O2 demand)
-heart failure
-anxiety
Adverse effects of beta blockers - (ANSWER)-bronchospasm due to beta-2 receptor interaction
-CNS effects