Walden 6630 Psychopharmacology
Final Exam Nurs6630N Questions and Answers
D2
in 1976 in by Creese and Colleagues who demonstrated that the antipsychotic
potency of a wide range of agents correlated closely with affinity for the
_________receptor which explained the equivalency of efficacy between agents
since they were all acting via the same mechanism
Risperidone
a D2 and 5HT2a antagonist, the first agent designed to follow clozapine’s example
as an "atypical anti-psychotic' with the goal of reduced EPS and enhanced efficacy
Olanzapine (Zyprexa)
a chemical derivative of clozapine, similarly demonstrated reduced EPS and
superior efficacy compared to haloperidol.
Risperidone and olanzapine
rapidly replaced the first generation of neuroleptics, particularly after clinicians
became convinced that the risk of Tardive Dyskinesia was substantially lower
Risperidone
markedly elevates prolactin levels
olanzapine
side effect is weight gain
Aripiprazole (Abilify)
differed from the other second generation anti-psychotics by possessing partial
agonist activity at the D2 receptor rather than full antagonism.
Risperdone
became the first atypical agent available as a long acting injection in the form of
"risperdone microspheres."
Paliperidone (Invega)
Walden 6630 Psychopharmacology
, Walden 6630 Psychopharmacology
several additional atypical agents have become available , inluding a metabolite of
risperdone
atypical anti-psychotics
a series of studies linked these _______ with insulin resistance and a heightened
risk for diabetes mellitus and dyslipidemia.
anti-psychotics
all _______________________ share dopamine 2 blockade as the presumed main
mechanism of action
Positive symptoms of psychosis
disorganization, delusions and hallucinations
positive symptoms of psychosis and agitation
primary symptom targets of anti-psychotics are , their efficacy for negative
symptoms and cognitive deficits of schizophrenia is questionable
first generation antipsychotics (typical) or conventional
characterized by their Extrapyramidal side effects,
first generation anti-psychotics (typical)
the main risks of these ________ are neurological side effects (dystonias, akathisia,
parkinsonism, TD
second generation anti-psychotics (atypical)
metabolic problems have emerged as major problems such as weight gain,
dyslipidemia, hyperglycemia
olanzapine, clozapine
for refractory patients these anti-psychotics have been most efficacious
clozapine
this medications clinical use is limited to refractory patients because of serious side
effects (including agranulocytosis and metabolic problems) even though it is the
most effective anti-psychotic and has minimal to no risk for EPS.
Walden 6630 Psychopharmacology
Final Exam Nurs6630N Questions and Answers
D2
in 1976 in by Creese and Colleagues who demonstrated that the antipsychotic
potency of a wide range of agents correlated closely with affinity for the
_________receptor which explained the equivalency of efficacy between agents
since they were all acting via the same mechanism
Risperidone
a D2 and 5HT2a antagonist, the first agent designed to follow clozapine’s example
as an "atypical anti-psychotic' with the goal of reduced EPS and enhanced efficacy
Olanzapine (Zyprexa)
a chemical derivative of clozapine, similarly demonstrated reduced EPS and
superior efficacy compared to haloperidol.
Risperidone and olanzapine
rapidly replaced the first generation of neuroleptics, particularly after clinicians
became convinced that the risk of Tardive Dyskinesia was substantially lower
Risperidone
markedly elevates prolactin levels
olanzapine
side effect is weight gain
Aripiprazole (Abilify)
differed from the other second generation anti-psychotics by possessing partial
agonist activity at the D2 receptor rather than full antagonism.
Risperdone
became the first atypical agent available as a long acting injection in the form of
"risperdone microspheres."
Paliperidone (Invega)
Walden 6630 Psychopharmacology
, Walden 6630 Psychopharmacology
several additional atypical agents have become available , inluding a metabolite of
risperdone
atypical anti-psychotics
a series of studies linked these _______ with insulin resistance and a heightened
risk for diabetes mellitus and dyslipidemia.
anti-psychotics
all _______________________ share dopamine 2 blockade as the presumed main
mechanism of action
Positive symptoms of psychosis
disorganization, delusions and hallucinations
positive symptoms of psychosis and agitation
primary symptom targets of anti-psychotics are , their efficacy for negative
symptoms and cognitive deficits of schizophrenia is questionable
first generation antipsychotics (typical) or conventional
characterized by their Extrapyramidal side effects,
first generation anti-psychotics (typical)
the main risks of these ________ are neurological side effects (dystonias, akathisia,
parkinsonism, TD
second generation anti-psychotics (atypical)
metabolic problems have emerged as major problems such as weight gain,
dyslipidemia, hyperglycemia
olanzapine, clozapine
for refractory patients these anti-psychotics have been most efficacious
clozapine
this medications clinical use is limited to refractory patients because of serious side
effects (including agranulocytosis and metabolic problems) even though it is the
most effective anti-psychotic and has minimal to no risk for EPS.
Walden 6630 Psychopharmacology
