Solutions for Organic
Synthesis, 5th Edition
retrosynthetic analysis - ANSWERSdesigning a synthesis by working backward from product to
reactant
5 or less - ANSWERSho many carbon atoms do 'readily available starting materials' have?
synthons - ANSWERSterm used to describe idealized fragments in retrosynthesis
functional group interconversion - ANSWERSterm used in retroynthesis to describe the process of
converting one functional group into another e.g. by oxidation or reduction
E2 - ANSWERSthe bimolecular and concerted elimination reaction
no - ANSWERSdoes the RDS of an E1 reaction involve a base?
alkenes - ANSWERSwhat are the products of an elimination reaction?
E1 - ANSWERSname this reaction
E2 - ANSWERSname this reaction
E - ANSWERSare Z or E alkenes usually lower in energy?
anti-periplanar - ANSWERSwhat orientation do the orbitals have to have for E2 to take place?
polar - ANSWERSwhat type of solvents favour E1?
aldol reactions - ANSWERSname these reactions
, beta-hydroxy ketone - ANSWERSwhat is the product of an aldol reaction?
Wittig Reaction - ANSWERSgive an example of an elimination reaction that does not involve the loss
of H
syn - ANSWERSis the wittig reaction a syn or anti elimination?
carbonyl compound and a phophonium ylide - ANSWERSwhat are the two reactants of a wittig
reaction?
ylide - ANSWERSa neutral molecule with positive and negative charges on adjacent atoms
Wittig Reaction - ANSWERSname this overall reaction
phosphonium ylide - ANSWERSname this compound
phosphine oxide formation - ANSWERSwhat is the driving force of the wittig reaction?
alkene and phosphine oxide - ANSWERSwhat are the two products of the wittig reaciton?
stabilized ylides - ANSWERStype of ylide that has conjugation or anion stabilizing substituents
unstabilized ylides - ANSWERSyildes that do not have conjugation or anion stabilizing substituents
E - ANSWERSdo stablized ylides in the wittig reaciton produce E or Z alkenes?
Z - ANSWERSdo unstablized ylides in the wittig reaciton produce E or Z alkenes?
stereoselective - ANSWERSterm to describe when one isomer is favoured over the other
Synthesis, 5th Edition
retrosynthetic analysis - ANSWERSdesigning a synthesis by working backward from product to
reactant
5 or less - ANSWERSho many carbon atoms do 'readily available starting materials' have?
synthons - ANSWERSterm used to describe idealized fragments in retrosynthesis
functional group interconversion - ANSWERSterm used in retroynthesis to describe the process of
converting one functional group into another e.g. by oxidation or reduction
E2 - ANSWERSthe bimolecular and concerted elimination reaction
no - ANSWERSdoes the RDS of an E1 reaction involve a base?
alkenes - ANSWERSwhat are the products of an elimination reaction?
E1 - ANSWERSname this reaction
E2 - ANSWERSname this reaction
E - ANSWERSare Z or E alkenes usually lower in energy?
anti-periplanar - ANSWERSwhat orientation do the orbitals have to have for E2 to take place?
polar - ANSWERSwhat type of solvents favour E1?
aldol reactions - ANSWERSname these reactions
, beta-hydroxy ketone - ANSWERSwhat is the product of an aldol reaction?
Wittig Reaction - ANSWERSgive an example of an elimination reaction that does not involve the loss
of H
syn - ANSWERSis the wittig reaction a syn or anti elimination?
carbonyl compound and a phophonium ylide - ANSWERSwhat are the two reactants of a wittig
reaction?
ylide - ANSWERSa neutral molecule with positive and negative charges on adjacent atoms
Wittig Reaction - ANSWERSname this overall reaction
phosphonium ylide - ANSWERSname this compound
phosphine oxide formation - ANSWERSwhat is the driving force of the wittig reaction?
alkene and phosphine oxide - ANSWERSwhat are the two products of the wittig reaciton?
stabilized ylides - ANSWERStype of ylide that has conjugation or anion stabilizing substituents
unstabilized ylides - ANSWERSyildes that do not have conjugation or anion stabilizing substituents
E - ANSWERSdo stablized ylides in the wittig reaciton produce E or Z alkenes?
Z - ANSWERSdo unstablized ylides in the wittig reaciton produce E or Z alkenes?
stereoselective - ANSWERSterm to describe when one isomer is favoured over the other
