Immunologie
,Inhoud
Kick-Off dag............................................................................................................................................5
Celbiologie..........................................................................................................................................5
Immunologie......................................................................................................................................5
CBO.....................................................................................................................................................5
CIE.......................................................................................................................................................5
Intro................................................................................................................................................7
Ziek worden....................................................................................................................................7
Het binnengedrongen pathogeen.......................................................................................................8
Cellulair immuunsysteem...............................................................................................................8
Humorale immuunsysteem............................................................................................................9
Immuniteit..........................................................................................................................................9
Aangeboren....................................................................................................................................9
Verworven......................................................................................................................................9
Fagocytose............................................................................................................................................10
Fagocytose in extracellulaire pathogenen....................................................................................10
Fagocytose in Intracellulaire pathogenen.....................................................................................11
T cellen.............................................................................................................................................12
Inhoud hoorcollege.......................................................................................................................13
Eerstelijnsdefensie mechanisme..........................................................................................................13
Huid..............................................................................................................................................13
Slijmvliezen...................................................................................................................................15
Microbioom in darmen.................................................................................................................15
Complementsysteem....................................................................................................................16
Leerdoelen....................................................................................................................................16
Pathway........................................................................................................................................16
Activatie complement systeem.....................................................................................................16
Na de activatie..............................................................................................................................17
Complement activatie...................................................................................................................17
Effector functies............................................................................................................................18
Zelf en niet-zelf.............................................................................................................................19
PAMPs..........................................................................................................................................19
Leerdoelen....................................................................................................................................20
Macrofagen..................................................................................................................................20
PRR’s.............................................................................................................................................21
2|Pagina
, TLR en NLR....................................................................................................................................22
Cytokines......................................................................................................................................25
IL- 1β & TNF-α...............................................................................................................................25
CXCL8............................................................................................................................................25
Ontsteking herkennen..................................................................................................................26
Neutrofiele granulocyten..............................................................................................................27
Functie..........................................................................................................................................27
Korte herinnering aan fagocytose.................................................................................................27
Granules neutrofiel.......................................................................................................................27
Doodgaan van Neutrofiel..............................................................................................................28
Bacteriën..............................................................................................................................................29
Antilichamen.....................................................................................................................................29
B-lymfocyten................................................................................................................................29
Neutrofiele granulocyt..................................................................................................................30
Virussen............................................................................................................................................30
Cytotoxische T cellen....................................................................................................................30
Macrofagen..................................................................................................................................30
Antilichamen.................................................................................................................................30
Parasieten.........................................................................................................................................31
Hoe gaat dit precies te werk.........................................................................................................31
Hoe weet je lichaam welke cellen er nodig zijn?..........................................................................31
B-cellen > andere route........................................................................................................................32
Naive T cel....................................................................................................................................33
T cel en zijn receptor........................................................................................................................33
MHC..............................................................................................................................................34
TCR-diversiteit..............................................................................................................................36
T cel ontwikkeling en training.......................................................................................................37
Primaire weefsels.........................................................................................................................38
Positieve selectie..............................................................................................................................38
Negatieve selectie.........................................................................................................................39
Van T cel > Effector cel..................................................................................................................39
Naïve T- cellen (Tn)...........................................................................................................................40
Effector T-cellen................................................................................................................................40
De activatie van de Tn cellen........................................................................................................40
Lymfeknoop..................................................................................................................................41
Activatie van Tn cellen door dc’ s.....................................................................................................42
3|Pagina
, CD80/CD86...................................................................................................................................42
Naïve CD4 T cellen........................................................................................................................43
Innate vs Adaptive........................................................................................................................45
Infectie..........................................................................................................................................45
Geheugen T cel.............................................................................................................................45
Herhaling......................................................................................................................................47
Antigen- antilichaam interactie....................................................................................................47
Verschillende klasse antilichamen................................................................................................48
IgD................................................................................................................................................48
IgE.................................................................................................................................................48
IgM................................................................................................................................................48
IgA.................................................................................................................................................48
IgG................................................................................................................................................48
Affiniteit en aviditeit.....................................................................................................................49
Antilichaam variatie......................................................................................................................49
Hoe husselt de B cel de fragmenten.............................................................................................50
B cel ontwikkeling in het beenmerg..............................................................................................50
En dan...........................................................................................................................................51
Cross presentatie..........................................................................................................................61
Antilichamen tegen intracellulaire pathogenen...........................................................................62
Celgemedieerde cytotoxiciteit..........................................................................................................63
NK-cellen......................................................................................................................................66
Regulatoire T cellen (Treg)............................................................................................................69
iTregs............................................................................................................................................71
nTregs...........................................................................................................................................71
4|Pagina
,Inhoud
Kick-Off dag............................................................................................................................................5
Celbiologie..........................................................................................................................................5
Immunologie......................................................................................................................................5
CBO.....................................................................................................................................................5
CIE.......................................................................................................................................................5
Intro................................................................................................................................................7
Ziek worden....................................................................................................................................7
Het binnengedrongen pathogeen.......................................................................................................8
Cellulair immuunsysteem...............................................................................................................8
Humorale immuunsysteem............................................................................................................9
Immuniteit..........................................................................................................................................9
Aangeboren....................................................................................................................................9
Verworven......................................................................................................................................9
Fagocytose............................................................................................................................................10
Fagocytose in extracellulaire pathogenen....................................................................................10
Fagocytose in Intracellulaire pathogenen.....................................................................................11
T cellen.............................................................................................................................................12
Inhoud hoorcollege.......................................................................................................................13
Eerstelijnsdefensie mechanisme..........................................................................................................13
Huid..............................................................................................................................................13
Slijmvliezen...................................................................................................................................15
Microbioom in darmen.................................................................................................................15
Complementsysteem....................................................................................................................16
Leerdoelen....................................................................................................................................16
Pathway........................................................................................................................................16
Activatie complement systeem.....................................................................................................16
Na de activatie..............................................................................................................................17
Complement activatie...................................................................................................................17
Effector functies............................................................................................................................18
Zelf en niet-zelf.............................................................................................................................19
PAMPs..........................................................................................................................................19
Leerdoelen....................................................................................................................................20
Macrofagen..................................................................................................................................20
PRR’s.............................................................................................................................................21
2|Pagina
, TLR en NLR....................................................................................................................................22
Cytokines......................................................................................................................................25
IL- 1β & TNF-α...............................................................................................................................25
CXCL8............................................................................................................................................25
Ontsteking herkennen..................................................................................................................26
Neutrofiele granulocyten..............................................................................................................27
Functie..........................................................................................................................................27
Korte herinnering aan fagocytose.................................................................................................27
Granules neutrofiel.......................................................................................................................27
Doodgaan van Neutrofiel..............................................................................................................28
Bacteriën..............................................................................................................................................29
Antilichamen.....................................................................................................................................29
B-lymfocyten................................................................................................................................29
Neutrofiele granulocyt..................................................................................................................30
Virussen............................................................................................................................................30
Cytotoxische T cellen....................................................................................................................30
Macrofagen..................................................................................................................................30
Antilichamen.................................................................................................................................30
Parasieten.........................................................................................................................................31
Hoe gaat dit precies te werk.........................................................................................................31
Hoe weet je lichaam welke cellen er nodig zijn?..........................................................................31
B-cellen > andere route........................................................................................................................32
Naive T cel....................................................................................................................................33
T cel en zijn receptor........................................................................................................................33
MHC..............................................................................................................................................34
TCR-diversiteit..............................................................................................................................36
T cel ontwikkeling en training.......................................................................................................37
Primaire weefsels.........................................................................................................................38
Positieve selectie..............................................................................................................................38
Negatieve selectie.........................................................................................................................39
Van T cel > Effector cel..................................................................................................................39
Naïve T- cellen (Tn)...........................................................................................................................40
Effector T-cellen................................................................................................................................40
De activatie van de Tn cellen........................................................................................................40
Lymfeknoop..................................................................................................................................41
Activatie van Tn cellen door dc’ s.....................................................................................................42
3|Pagina
, CD80/CD86...................................................................................................................................42
Naïve CD4 T cellen........................................................................................................................43
Innate vs Adaptive........................................................................................................................45
Infectie..........................................................................................................................................45
Geheugen T cel.............................................................................................................................45
Herhaling......................................................................................................................................47
Antigen- antilichaam interactie....................................................................................................47
Verschillende klasse antilichamen................................................................................................48
IgD................................................................................................................................................48
IgE.................................................................................................................................................48
IgM................................................................................................................................................48
IgA.................................................................................................................................................48
IgG................................................................................................................................................48
Affiniteit en aviditeit.....................................................................................................................49
Antilichaam variatie......................................................................................................................49
Hoe husselt de B cel de fragmenten.............................................................................................50
B cel ontwikkeling in het beenmerg..............................................................................................50
En dan...........................................................................................................................................51
Cross presentatie..........................................................................................................................61
Antilichamen tegen intracellulaire pathogenen...........................................................................62
Celgemedieerde cytotoxiciteit..........................................................................................................63
NK-cellen......................................................................................................................................66
Regulatoire T cellen (Treg)............................................................................................................69
iTregs............................................................................................................................................71
nTregs...........................................................................................................................................71
4|Pagina
