DRUG TREAMENT FOR PARKINSON'S DISEASE
Dr Ofor
, PAR
ARS DIS S
&
Parkinson's disease is a
progressive neurodegenerative disorder
of
the
I
topaminergia nigra pars compacta (SNPC)
the substantia
neurons in that
generates dopamine to the striatum This disorder affects the strictur and the
.
basal
substantia the
gra in These
gangha
the brain
parts of are
charged
-
- This disorder results
with the vote of coordinating movement in motor
dysfunction in
the
body .
The disease
pathognomonic feature of this is loss
of prgmented dopaminergia
substantia and untracellular inclusions called
~ curons
of migra appearance of
Lawy bodies
.
↑ was first discovered by James Parkinson in 1817 when he called it
paralysis agorans (shaling Balsy)
.
&ATHOY310LOGY
Parkinson's disease develops when the neurons
connecting the substantia
nigra
to the stratum
progressively degenerates -
Since the
dopaminergic neurons that
originate in the substantia nigua normally
GAA neurons located in the striatum
exert
inhibitory effects on
,
too little dopamine
well
results in more GABA ,
causing
inhibition
of
the thalamus as as
reducing
. This increased inhibition
to the motor cortex thalamo-
the
excitatory unput of the
cortical pathway suppresses movement .
excation, samefopnogrfneurons Again rambatory effects
The also exert on
he re
,
without
sufficient levels of
dopamine ,
the production of Ach is uncreased which triggers a chain
of abnormal
signalingradingtimpressesisare afresturingthebalana
lords
a
on the brain
by the use
of dopaminergic agents or
anticholinergic agents
-
Dr Ofor
, PAR
ARS DIS S
&
Parkinson's disease is a
progressive neurodegenerative disorder
of
the
I
topaminergia nigra pars compacta (SNPC)
the substantia
neurons in that
generates dopamine to the striatum This disorder affects the strictur and the
.
basal
substantia the
gra in These
gangha
the brain
parts of are
charged
-
- This disorder results
with the vote of coordinating movement in motor
dysfunction in
the
body .
The disease
pathognomonic feature of this is loss
of prgmented dopaminergia
substantia and untracellular inclusions called
~ curons
of migra appearance of
Lawy bodies
.
↑ was first discovered by James Parkinson in 1817 when he called it
paralysis agorans (shaling Balsy)
.
&ATHOY310LOGY
Parkinson's disease develops when the neurons
connecting the substantia
nigra
to the stratum
progressively degenerates -
Since the
dopaminergic neurons that
originate in the substantia nigua normally
GAA neurons located in the striatum
exert
inhibitory effects on
,
too little dopamine
well
results in more GABA ,
causing
inhibition
of
the thalamus as as
reducing
. This increased inhibition
to the motor cortex thalamo-
the
excitatory unput of the
cortical pathway suppresses movement .
excation, samefopnogrfneurons Again rambatory effects
The also exert on
he re
,
without
sufficient levels of
dopamine ,
the production of Ach is uncreased which triggers a chain
of abnormal
signalingradingtimpressesisare afresturingthebalana
lords
a
on the brain
by the use
of dopaminergic agents or
anticholinergic agents
-
