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DLBCL ESMO Guideline Questions with
Answers (100% Correct Answers)
What percentage of non-Hodgkin lymphoma series does DLBCL constitute?
Answer: 30%-58%
What is the crude incidence of DLBCL in Europe? Answer: 3.8/100,000/year
What increases the risk of DLBCL? Answer: Family history of lymphoma,
autoimmune disease, HIV infection, HCV seropositivity, high body mass as a
young adult, some occupational exposures
What type of biopsy remains the optimal method of diagnosis for DLBCL?
Answer: Surgical excision biopsy
What should be avoided as the sole basis for diagnosing DLBCL? Answer:
Fine-needle aspirate
What must confirm a morphological diagnosis of DLBCL? Answer:
Immunophenotypic investigations
What should be considered if there is doubt in the diagnosis of DLBCL?
Answer: Demonstration of B-cell monoclonality by a PCR-based method
What is the recommended gold standard for staging DLBCL patients? Answer:
FDG-PET/CT scan
What staging classification system is used for DLBCL? Answer: Ann Arbor
classification system
What should be calculated for prognostic purposes in DLBCL? Answer:
International Prognostic Index (IPI) and age-adjusted IPI (aa-IPI)
What treatment strategy is the current standard for young low-risk DLBCL
patients without bulky disease? Answer: Six cycles of R-CHOP21
, 2
What is the recommended treatment for elderly DLBCL patients aged >80
years? Answer: R-miniCHOP
What is recommended for patients with high-intermediate-risk and high-risk
IPI in DLBCL? Answer: CNS prophylaxis
What should HIV-positive DLBCL patients receive in addition to antiviral
therapy? Answer: Same treatment as HIV-negative patients
What is the recommended standard for post-treatment assessment in DLBCL?
Answer: FDG-PET/CT
What percentage of DLBCL cases ultimately relapse? Answer: More than 30%
What is a common salvage regimen for relapsed DLBCL? Answer: R-DHAP
or R-ICE
What type of transplantation may be considered for patients with refractory
disease, early relapse, or relapse after ASCT? Answer: Allogeneic
transplantation
What is the molecular subtype of DLBCL associated with a worse prognosis
when treated with R-CHOP? Answer: Activated B-cell (ABC) subtype
Which kinase inhibitor has shown selective activity in ABC-DLBCL? Answer:
Ibrutinib
What is the standard treatment for DLBCL in patients aged 60-80 years?
Answer: Six to eight cycles of R-CHOP21
What is the main therapeutic concern for patients with cardiac dysfunction or
who are frail or unfit? Answer: Substitution or omission of doxorubicin
What is the predictive value of early PET evaluation in DLBCL treatment?
Answer: Predictive of outcome, reserved for clinical trials
What type of assessment is crucial in guiding treatment choices for elderly
DLBCL patients? Answer: Comprehensive geriatric assessment
DLBCL ESMO Guideline Questions with
Answers (100% Correct Answers)
What percentage of non-Hodgkin lymphoma series does DLBCL constitute?
Answer: 30%-58%
What is the crude incidence of DLBCL in Europe? Answer: 3.8/100,000/year
What increases the risk of DLBCL? Answer: Family history of lymphoma,
autoimmune disease, HIV infection, HCV seropositivity, high body mass as a
young adult, some occupational exposures
What type of biopsy remains the optimal method of diagnosis for DLBCL?
Answer: Surgical excision biopsy
What should be avoided as the sole basis for diagnosing DLBCL? Answer:
Fine-needle aspirate
What must confirm a morphological diagnosis of DLBCL? Answer:
Immunophenotypic investigations
What should be considered if there is doubt in the diagnosis of DLBCL?
Answer: Demonstration of B-cell monoclonality by a PCR-based method
What is the recommended gold standard for staging DLBCL patients? Answer:
FDG-PET/CT scan
What staging classification system is used for DLBCL? Answer: Ann Arbor
classification system
What should be calculated for prognostic purposes in DLBCL? Answer:
International Prognostic Index (IPI) and age-adjusted IPI (aa-IPI)
What treatment strategy is the current standard for young low-risk DLBCL
patients without bulky disease? Answer: Six cycles of R-CHOP21
, 2
What is the recommended treatment for elderly DLBCL patients aged >80
years? Answer: R-miniCHOP
What is recommended for patients with high-intermediate-risk and high-risk
IPI in DLBCL? Answer: CNS prophylaxis
What should HIV-positive DLBCL patients receive in addition to antiviral
therapy? Answer: Same treatment as HIV-negative patients
What is the recommended standard for post-treatment assessment in DLBCL?
Answer: FDG-PET/CT
What percentage of DLBCL cases ultimately relapse? Answer: More than 30%
What is a common salvage regimen for relapsed DLBCL? Answer: R-DHAP
or R-ICE
What type of transplantation may be considered for patients with refractory
disease, early relapse, or relapse after ASCT? Answer: Allogeneic
transplantation
What is the molecular subtype of DLBCL associated with a worse prognosis
when treated with R-CHOP? Answer: Activated B-cell (ABC) subtype
Which kinase inhibitor has shown selective activity in ABC-DLBCL? Answer:
Ibrutinib
What is the standard treatment for DLBCL in patients aged 60-80 years?
Answer: Six to eight cycles of R-CHOP21
What is the main therapeutic concern for patients with cardiac dysfunction or
who are frail or unfit? Answer: Substitution or omission of doxorubicin
What is the predictive value of early PET evaluation in DLBCL treatment?
Answer: Predictive of outcome, reserved for clinical trials
What type of assessment is crucial in guiding treatment choices for elderly
DLBCL patients? Answer: Comprehensive geriatric assessment
