DLBCL ESMO GUIDELINE EXAMINATION
TEST 2026 QUESTIONS WITH ANSWERS
GRADED A+
⩥ What is the crude incidence of DLBCL in Europe? Answer:
3.8/100,000/year
⩥ What increases the risk of DLBCL? Answer: Family history of
lymphoma, autoimmune disease, HIV infection, HCV seropositivity,
high body mass as a young adult, some occupational exposures
⩥ What type of biopsy remains the optimal method of diagnosis for
DLBCL? Answer: Surgical excision biopsy
⩥ What should be avoided as the sole basis for diagnosing DLBCL?
Answer: Fine-needle aspirate
⩥ What must confirm a morphological diagnosis of DLBCL? Answer:
Immunophenotypic investigations
⩥ What should be considered if there is doubt in the diagnosis of
DLBCL? Answer: Demonstration of B-cell monoclonality by a PCR-
based method
, ⩥ What is the recommended gold standard for staging DLBCL patients?
Answer: FDG-PET/CT scan
⩥ What staging classification system is used for DLBCL? Answer: Ann
Arbor classification system
⩥ What should be calculated for prognostic purposes in DLBCL?
Answer: International Prognostic Index (IPI) and age-adjusted IPI (aa-
IPI)
⩥ What treatment strategy is the current standard for young low-risk
DLBCL patients without bulky disease? Answer: Six cycles of R-
CHOP21
⩥ What is the recommended treatment for elderly DLBCL patients aged
>80 years? Answer: R-miniCHOP
⩥ What is recommended for patients with high-intermediate-risk and
high-risk IPI in DLBCL? Answer: CNS prophylaxis
⩥ What should HIV-positive DLBCL patients receive in addition to
antiviral therapy? Answer: Same treatment as HIV-negative patients
⩥ What is the recommended standard for post-treatment assessment in
DLBCL? Answer: FDG-PET/CT
TEST 2026 QUESTIONS WITH ANSWERS
GRADED A+
⩥ What is the crude incidence of DLBCL in Europe? Answer:
3.8/100,000/year
⩥ What increases the risk of DLBCL? Answer: Family history of
lymphoma, autoimmune disease, HIV infection, HCV seropositivity,
high body mass as a young adult, some occupational exposures
⩥ What type of biopsy remains the optimal method of diagnosis for
DLBCL? Answer: Surgical excision biopsy
⩥ What should be avoided as the sole basis for diagnosing DLBCL?
Answer: Fine-needle aspirate
⩥ What must confirm a morphological diagnosis of DLBCL? Answer:
Immunophenotypic investigations
⩥ What should be considered if there is doubt in the diagnosis of
DLBCL? Answer: Demonstration of B-cell monoclonality by a PCR-
based method
, ⩥ What is the recommended gold standard for staging DLBCL patients?
Answer: FDG-PET/CT scan
⩥ What staging classification system is used for DLBCL? Answer: Ann
Arbor classification system
⩥ What should be calculated for prognostic purposes in DLBCL?
Answer: International Prognostic Index (IPI) and age-adjusted IPI (aa-
IPI)
⩥ What treatment strategy is the current standard for young low-risk
DLBCL patients without bulky disease? Answer: Six cycles of R-
CHOP21
⩥ What is the recommended treatment for elderly DLBCL patients aged
>80 years? Answer: R-miniCHOP
⩥ What is recommended for patients with high-intermediate-risk and
high-risk IPI in DLBCL? Answer: CNS prophylaxis
⩥ What should HIV-positive DLBCL patients receive in addition to
antiviral therapy? Answer: Same treatment as HIV-negative patients
⩥ What is the recommended standard for post-treatment assessment in
DLBCL? Answer: FDG-PET/CT
