DRUGS FOR BRONCHIAL AST
(MBBS Pharmacology Notes)
1. Bronchial Asthma: Pathophysiology Sn
Asthma is a chronic inflammatory disorder of the airways, leading
wheezing, cough, chest tightness, and dyspnea.
👉 *Key Features:* Airway inflammation, *bronchial hyperresponsivenes
reversible airflow obstruction.
👉 *Inflammation:* Involves mast cells, eosinophils, T-lymphocytes, an
like *Leukotrienes* and *Histamine*.
👉 *Autonomic Link (Relevant from ANS): **Parasympathetic (Vagus)
receptors* causes *Bronchoconstriction* (hence, Anticholinergics are
stimulation via *β2 receptors* causes *Bronchodilation* (hence, β2
mainstay).
2. Classification of Anti-Asthma Drugs
Anti-asthmatic drugs are broadly divided into two major functional ca
A. Quick-Relief Medications (RESCUERS)
Used to provide rapid, short-term symptom relief during an acute atta
⭐ *Short-Acting β2 Agonists (SABAs):* Salbutamol (Albuterol) , T
the first-line choice for acute attacks.
⭐ *Anticholinergics:* Ipratropium Bromide (especially for severe exace
with SABA).
⭐ *Systemic Corticosteroids:* Oral/IV Glucocorticoids (e.g., Prednisolon
exacerbations.
(MBBS Pharmacology Notes)
1. Bronchial Asthma: Pathophysiology Sn
Asthma is a chronic inflammatory disorder of the airways, leading
wheezing, cough, chest tightness, and dyspnea.
👉 *Key Features:* Airway inflammation, *bronchial hyperresponsivenes
reversible airflow obstruction.
👉 *Inflammation:* Involves mast cells, eosinophils, T-lymphocytes, an
like *Leukotrienes* and *Histamine*.
👉 *Autonomic Link (Relevant from ANS): **Parasympathetic (Vagus)
receptors* causes *Bronchoconstriction* (hence, Anticholinergics are
stimulation via *β2 receptors* causes *Bronchodilation* (hence, β2
mainstay).
2. Classification of Anti-Asthma Drugs
Anti-asthmatic drugs are broadly divided into two major functional ca
A. Quick-Relief Medications (RESCUERS)
Used to provide rapid, short-term symptom relief during an acute atta
⭐ *Short-Acting β2 Agonists (SABAs):* Salbutamol (Albuterol) , T
the first-line choice for acute attacks.
⭐ *Anticholinergics:* Ipratropium Bromide (especially for severe exace
with SABA).
⭐ *Systemic Corticosteroids:* Oral/IV Glucocorticoids (e.g., Prednisolon
exacerbations.
