CMN 548 -study guide 5 Practice Exam QUESTIONS AND CORRECT VERIFIED ANS WERS LATEST UPDATE JUST RELEASED

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CMN 548 -study guide 5 Practice Exam QUESTIONS
AND CORRECT VERIFIED ANS WERS LATEST UPDATE
JUST RELEASED


Question: Withdrawal symptoms are worse with drugs that have this pharmacokinetic property. -

ANSWER✔✔Short elimination half life




Question: Which medications are most often associated with mentally and physically distressing

discontinuation reactions? - ANSWER✔✔- Sedative hypnotics and opiates


- Barbiturate (part of the sedative hypnotic class) withdrawal can be fatal




Question: Which benzodiazepine produces more intense withdrawal symptoms that it's counterparts? -

ANSWER✔✔Alprazolam (Xanax)




Question: Which SSRI produces more intense withdrawal symptoms that it's counterparts? -

ANSWER✔✔Paroxetine (Paxil)




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Q:What are the two basic mechanisms for studying receptors? - ANSWER✔✔- Measure the binding of a

ligand (radioactively traced)


- Measure the physiologic consequences of agonist binding (and effects of the antagonist)




Question: How do didactic depictions of neurotransmitter signaling differ from real life? - ANSWER✔✔-

There are hundreds to thousands of axons connecting to one dendrite


- A single transmitter can evoke multiple pathways




Question: Pharmacokinetic drug interactions are... - ANSWER✔✔the effects of drugs on the PLASMA

concentrations of each other




Question: Pharmacokinetic concepts describe and predict... - ANSWER✔✔- the time course of drug

concentration in different parts of the body


- onset, duration, absorption, distribution, metabolism, excretion




Question: Remission - ANSWER✔✔- Preferred outcome of treatment


- Absolute score of 7 or less on the HAMD (Hamilton depression) scale


- <10 on the MADRS (Montgomery-Asberg Depression Rating Scale)


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Question: Responders are patients who... - ANSWER✔✔improve but do not experience full resolution

of symptoms


- 50% of greater decrease from baseline on HAMD and MADRS depression ratings




Question: What is the probability of remission from OCD with SSRI treatment over 3 years of

treatment? - ANSWER✔✔- 38% full remission


- 65% partial remission




Question: Medications with this pharmacokinetic property have delayed discontinuation symptoms. -

ANSWER✔✔Long elimination half life


- Fluoxetine (Prozac, SSRI) has a long elimination half life of its active metabolite




Question: What is autoinhibition? - ANSWER✔✔Dose dependent inhibition of a medication's own

metabolism


- Paroxetine (Paxil, SSRI) inhibits P450 CYP 2D6 which is what metabolizes the medication


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Question: Bupropion (Wellbutrin, atypical antidepressant) inhibits this enzyme system and paroxetine

(Paxil, SSRI) is metabolized by it. - ANSWER✔✔CYP 2D6


- Discontinuing bupropion would result in a rapid increase in metabolism of Paroxetine and drop in

plasma concentrations


- Paroxetine would need to be increased




Question: What effect have sustained release alprazolam, paroxetine, and venlafaxine had on

withdrawal reactions? - ANSWER✔✔None.


- They do not reduce severity of withdrawal because the long half life is due to delayed absorption not

prolonged elimination


- Only benefit is the in reduced dosing frequency




Question: Withdrawal symptoms present after hours or days of dose reduction or discontinuation and

resolve within... - ANSWER✔✔A few weeks


- Persistent symptoms would indicate something besides withdrawal


- Psychotic and mood symptoms DO NOT usually reappear abruptly after discontinuing long term

treatment




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