UNIT 3 - Quizzes and Exams, UNE
Biochemistry Unit 3 Questions
And Answers
An 11-year-old girl is brought to the emergency department by her father. He
reports she has recently been very thirsty and needing to make frequent trips
to the bathroom. At her soccer game today, she complained of
lightheadedness and that the symptoms did not resolve even after drinking a
power beverage. A rapid dipstick test revealed glucose in her urine and
further diagnostics are consistent with a diagnosis of type 1 diabetes.
Evaluation of this girl's liver would reveal an increased rate of which of the
following processes? Answers Ketogenesis
Which of the following lipoproteins distributes dietary lipids? Answers
chylomicron
In the fasted state, fatty acyl-CoA are transported across the mitochondrial
membrane. The transport of fatty acids via carnitine palmitoyl transferase I
(CPTI) can be directly inhibited by which of the following compounds?
a. Malonyl CoA
b. Carnitine
c. Acetyl CoA
d. Palmitate Answers Malonyl CoA
what is the role of adipose in metabolism Answers storage of TAG
The interaction of chylomicrons with lipoprotein lipase is stimulated by
which of the following Apo proteins? Answers ApoC II
Under fasting conditions (ratio of insulin to glucagon <1), elevated glucagon
will activate which of the following enzymes?
,a. glycogen synthase
b. lipoprotein lipase
c. hormone sensitive lipase
d. pyruvate dehydrogenase complex Answers hormone sensitive lipase
A 5-year-old female is brought to the emergency department by her mother.
She is a type 1 diabetic and has not taken her insulin while away at a day
camp. The child is unresponsive. Which of the following enzymes is
phosphorylated and active under these conditions? Answers Hormone
Sensitive lipase
Nascent chylomicrons are synthesized in which tissue? Answers Intestine
ATP can be generated by many metabolic pathways in the body. Which of the
following processes generates the most ATP?
a. glycogenolysis
b. fatty acid β-oxidation
c. pentose phosphate pathway
d. citric acid cycle Answers Fatty acid β-oxidation
During the fasted state, lipolysis is facilitated by the action of hormone
sensitive lipase. This enzyme requires which of the following modifications
for activation? Answers Phosphorylation
Bile salts are synthesized from cholesterol and are used for the
emulsification of dietary lipids. What is the primary fate of bile salts during
digestion? Answers They are reabsorbed in the ileum
In liver, which of the following key inhibitory events ensures that newly
synthesized palmitoyl-CoA is not immediately oxidized?
a. Inhibition of CPT-II by acetyl-CoA
b. Inhibition of CPT-I by malonyl-CoA
c. Inhibition of CPT-I by palmitoyl-carnitine
d. Inhibition of acyl-CoA synthetase by malonyl-CoA Answers Inhibition of
CPT-I by malonyl-CoA
,Ketonuria, hyperglycemia and severe acidosis are prime diagnostic
indicators of the presentation of Type I diabetic ketoacidosis. Which of the
following compounds are "ketone bodies" that would be elevated in serum
and urine of a patient in this condition?
a. fumarate and succinate
b. pyruvate and lactate
c. acetone and ethanol
d. D-3-hydroxybutyrate and acetoacetate
e. oxaloacetate and pyruvate Answers D-3-hydroxybutyrate and
acetoacetate
Nascent chylomicrons interact with HDL particles and obtain which of the
following Apo protiens? Answers ApoCII and ApoE
A well, 2-year-old girl contracted a vi ral i l lness at day care with vomiting,
diarrhea, and progressive lethargy. She presents to the cl inic with
disorientation, a barely rousable sensorium, cracked l ips, sunken eyes, lack
of tears, flaccid skin with "tenting" weak pulse with low blood pressure, and
increased deep tendon reflexes. Laboratory tests show low blood glucose,
normal electrolytes, elevated l iver enzymes, and (on chest X-ray) a dilated
heart. Urinalysis reveals no infection and no ketones. The child i s
hospitalized and stabilized with 10% glucose infusion. Admission laboratories
show elevated medium-chain fatty acylcarnitines in blood and 6-8 carbon
dicarboxylic acids in the urine. Which of the following abnormalities i s the
most l ikely diagnosis in this child? Answers Defect of medium-chain
coenzyme A deydrogenase
An individual is on a hunger strike and has not eaten in 13 days. Which of the
following best describes their metabolic state? Answers The brain will be
preferentially oxidizing ketones.
The activity of pancreatic lipase is inhibited by which of the following
compounds? Answers Bile salts
Which of the following is NOT a product of β-oxidation?
a. NADH
b. FADH2
, c. NADPH
d. Acetyl-CoA Answers NADPH
Under fasting conditions (ratio of insulin to glucagon <1), elevated glucagon
will activate which of the following enzymes? Answers Hormone sensitive
lipase
Which of the following statements regarding lipid digestion and absorption is
true?
A. The products of lipid digestion travel in the circulatory system in the form
of micelles.
B. The products of lipid digestion diffuse into capillaries in the vicinity of the
intestinal epithelium.
C. Pancreatic lipase emulsifies lipids.
D. The products of lipid digestion are resynthesized into triacylglycerols in
intestinal epithelial cells.
E. In the absence of bile salts, no digestion of lipids would occur. Answers
The products of lipid digestion are resynthesized into triacylglycerols in
intestinal epithelial cells.
A well, 2-year-old girl presents to the clinic with symptoms of a viral illness.
Her parents report she has had bouts of vomiting and diarrhea over the last
24 hours. This morning they could barely wake her from her crib and she was
very weak. Laboratory tests show low blood glucose (hypoglycemia) and
elevated liver enzymes. There are no ketones present in her urine. The child
is hospitalized and glucose is administered by I.V. Additional laboratory tests
showed elevated medium-chain fatty acyl carnitines in blood and 6-8 carbon
dicarboxylic acids in the urine. Which of the following abnormalities is the
most likely diagnosis for this child? Answers Defect of medium-chain
coenzyme A dehydrogenase
Biochemistry Unit 3 Questions
And Answers
An 11-year-old girl is brought to the emergency department by her father. He
reports she has recently been very thirsty and needing to make frequent trips
to the bathroom. At her soccer game today, she complained of
lightheadedness and that the symptoms did not resolve even after drinking a
power beverage. A rapid dipstick test revealed glucose in her urine and
further diagnostics are consistent with a diagnosis of type 1 diabetes.
Evaluation of this girl's liver would reveal an increased rate of which of the
following processes? Answers Ketogenesis
Which of the following lipoproteins distributes dietary lipids? Answers
chylomicron
In the fasted state, fatty acyl-CoA are transported across the mitochondrial
membrane. The transport of fatty acids via carnitine palmitoyl transferase I
(CPTI) can be directly inhibited by which of the following compounds?
a. Malonyl CoA
b. Carnitine
c. Acetyl CoA
d. Palmitate Answers Malonyl CoA
what is the role of adipose in metabolism Answers storage of TAG
The interaction of chylomicrons with lipoprotein lipase is stimulated by
which of the following Apo proteins? Answers ApoC II
Under fasting conditions (ratio of insulin to glucagon <1), elevated glucagon
will activate which of the following enzymes?
,a. glycogen synthase
b. lipoprotein lipase
c. hormone sensitive lipase
d. pyruvate dehydrogenase complex Answers hormone sensitive lipase
A 5-year-old female is brought to the emergency department by her mother.
She is a type 1 diabetic and has not taken her insulin while away at a day
camp. The child is unresponsive. Which of the following enzymes is
phosphorylated and active under these conditions? Answers Hormone
Sensitive lipase
Nascent chylomicrons are synthesized in which tissue? Answers Intestine
ATP can be generated by many metabolic pathways in the body. Which of the
following processes generates the most ATP?
a. glycogenolysis
b. fatty acid β-oxidation
c. pentose phosphate pathway
d. citric acid cycle Answers Fatty acid β-oxidation
During the fasted state, lipolysis is facilitated by the action of hormone
sensitive lipase. This enzyme requires which of the following modifications
for activation? Answers Phosphorylation
Bile salts are synthesized from cholesterol and are used for the
emulsification of dietary lipids. What is the primary fate of bile salts during
digestion? Answers They are reabsorbed in the ileum
In liver, which of the following key inhibitory events ensures that newly
synthesized palmitoyl-CoA is not immediately oxidized?
a. Inhibition of CPT-II by acetyl-CoA
b. Inhibition of CPT-I by malonyl-CoA
c. Inhibition of CPT-I by palmitoyl-carnitine
d. Inhibition of acyl-CoA synthetase by malonyl-CoA Answers Inhibition of
CPT-I by malonyl-CoA
,Ketonuria, hyperglycemia and severe acidosis are prime diagnostic
indicators of the presentation of Type I diabetic ketoacidosis. Which of the
following compounds are "ketone bodies" that would be elevated in serum
and urine of a patient in this condition?
a. fumarate and succinate
b. pyruvate and lactate
c. acetone and ethanol
d. D-3-hydroxybutyrate and acetoacetate
e. oxaloacetate and pyruvate Answers D-3-hydroxybutyrate and
acetoacetate
Nascent chylomicrons interact with HDL particles and obtain which of the
following Apo protiens? Answers ApoCII and ApoE
A well, 2-year-old girl contracted a vi ral i l lness at day care with vomiting,
diarrhea, and progressive lethargy. She presents to the cl inic with
disorientation, a barely rousable sensorium, cracked l ips, sunken eyes, lack
of tears, flaccid skin with "tenting" weak pulse with low blood pressure, and
increased deep tendon reflexes. Laboratory tests show low blood glucose,
normal electrolytes, elevated l iver enzymes, and (on chest X-ray) a dilated
heart. Urinalysis reveals no infection and no ketones. The child i s
hospitalized and stabilized with 10% glucose infusion. Admission laboratories
show elevated medium-chain fatty acylcarnitines in blood and 6-8 carbon
dicarboxylic acids in the urine. Which of the following abnormalities i s the
most l ikely diagnosis in this child? Answers Defect of medium-chain
coenzyme A deydrogenase
An individual is on a hunger strike and has not eaten in 13 days. Which of the
following best describes their metabolic state? Answers The brain will be
preferentially oxidizing ketones.
The activity of pancreatic lipase is inhibited by which of the following
compounds? Answers Bile salts
Which of the following is NOT a product of β-oxidation?
a. NADH
b. FADH2
, c. NADPH
d. Acetyl-CoA Answers NADPH
Under fasting conditions (ratio of insulin to glucagon <1), elevated glucagon
will activate which of the following enzymes? Answers Hormone sensitive
lipase
Which of the following statements regarding lipid digestion and absorption is
true?
A. The products of lipid digestion travel in the circulatory system in the form
of micelles.
B. The products of lipid digestion diffuse into capillaries in the vicinity of the
intestinal epithelium.
C. Pancreatic lipase emulsifies lipids.
D. The products of lipid digestion are resynthesized into triacylglycerols in
intestinal epithelial cells.
E. In the absence of bile salts, no digestion of lipids would occur. Answers
The products of lipid digestion are resynthesized into triacylglycerols in
intestinal epithelial cells.
A well, 2-year-old girl presents to the clinic with symptoms of a viral illness.
Her parents report she has had bouts of vomiting and diarrhea over the last
24 hours. This morning they could barely wake her from her crib and she was
very weak. Laboratory tests show low blood glucose (hypoglycemia) and
elevated liver enzymes. There are no ketones present in her urine. The child
is hospitalized and glucose is administered by I.V. Additional laboratory tests
showed elevated medium-chain fatty acyl carnitines in blood and 6-8 carbon
dicarboxylic acids in the urine. Which of the following abnormalities is the
most likely diagnosis for this child? Answers Defect of medium-chain
coenzyme A dehydrogenase
