WGU D116 ADVANCED PHARMACOLOGY ACTUAL EXAM STUDY GUIDE 2025/2026 QUESTIONS WITH VERIFIED CORRECT SOLUTIONS || 100% GUARANTEED PASS BRAND NEW VERSION

Doxorubicin BBW - ANSWER Cardiotoxicity (cumulative dose), secondary malignancy Trastuzumab BBW - ANSWER Cardiomyopathy, fetal toxicity Bevacizumab BBW - ANSWER GI perforation, impaired wound healing, hemorrhage Tamoxifen BBW - ANSWER Uterine cancer, thromboembolism Linezolid BBW - ANSWER Serotonin syndrome risk when combined with serotonergic agents Chloramphenicol BBW - ANSWER Aplastic anemia, bone marrow suppression Isoniazid BBW - ANSWER Hepatotoxicity ACE inhibitors / ARBs BBW (Pregnancy) - ANSWER Fetal renal damage, oligohydramnios, skull hypoplasia Valproic acid BBW (Pregnancy) - ANSWER Neural tube defects, cognitive deficits in fetus Warfarin BBW (Pregnancy) - ANSWER Fetal hemorrhage, skeletal abnormalities (especially 1st trimester) What factor can be attributed to limited prescriptive authority for APRNs? - ANSWER Inaccessibility of patient care A patient reports that a medication prescribed for recurrent migraine headaches is not working. Which action should be taken first? - ANSWER Ask the patient about the number and frequency of tablets taken. A patient is receiving intravenous gentamicin. A serum drug test reveals toxic levels. The dosing is correct, and this medication has been tolerated by this patient in the past. Which could be a probable cause of the test result? - ANSWER The patient is taking another medication that binds to serum albumin The nurse gives a patient multiple medications that compete for plasma albumin receptor sites. What might occur? - ANSWER Binding of one or both agents will be reduced; Plasma levels of free drug will rise; The increase in free drug will intensify effects A patient responds differently to a drug than a friend taking the same drug. What is the most common cause? - ANSWER Metabolism of drugs A patient with migraines is started on a beta blocker. Which statement indicates understanding? - ANSWER "I need to take it every day to reduce the frequency of migraines." A prescriber orders transdermal clonidine. What should the nurse teach? - ANSWER Change the patch every week. Before beginning pramipexole for Parkinson disease, what should the nurse ask about? - ANSWER Any history of alcohol abuse or compulsive behaviors A patient taking memantine has an increased creatinine. What will the provider do? - ANSWER Adjust the dose if the creatinine clearance is less than 30 mL/min Which statement by a student indicates understanding of memantine? - ANSWER "Memantine modulates the effects of glutamate to alter calcium influx into neurons." Cholinesterase inhibitor - ANSWER A drug that prevents breakdown of acetylcholine, used to treat Alzheimer symptoms Which statement indicates need for further teaching about cholinesterase inhibitors? - ANSWER "This drug significantly slows the progression of the disease." Which side effects of cholinesterase inhibitors concern the nurse? - ANSWER Slowed heart rate and lightheadedness A patient taking an FGA has shuffling gait and tremors. What action is needed? - ANSWER Giving an anticholinergic medication Which ACE inhibitor side effect will NOT occur with ARBs? - ANSWER Cough A nurse administers an ACE inhibitor for the first time. What should be done? - ANSWER Instruct the patient not to get up without assistance What should a pregnant patient taking an ACE inhibitor be told? - ANSWER Stop taking the medication and contact the provider immediately A patient begins an HMG-CoA reductase inhibitor. Which statement is correct? - ANSWER Statins lower LDL and total cholesterol An 88-year-old in Stage D heart failure is rehospitalized. What should be discussed? - ANSWER End-of-life care A patient with repeated BP readings of ~150/95 will likely receive what? - ANSWER A thiazide diuretic A diabetic patient develops hypertension. Which medication is preferred? - ANSWER ACE inhibitors A patient taking digoxin and furosemide reports yellow halos. What should the nurse do? - ANSWER Check for other symptoms of digitalis toxicity A patient trying to get pregnant asks about supplements. What should the nurse recommend? - ANSWER 400 to 800 mg of folic acid per day Which finding indicates terazosin has been effective for BPH? - ANSWER Improved urinary hesitation Which bronchodilator is preferred for stable COPD? - ANSWER A long-acting inhaled beta2 agonist A patient with asthma exacerbation still wheezes after SABA use. What should be added? - ANSWER Add a systemic glucocorticoid Which medication is used for step 1 asthma management? - ANSWER Short-acting beta2 agonists A patient asks about LABAs for frequent asthma exacerbations. What should the nurse say? - ANSWER LABAs should be combined with an inhaled glucocorticoid. A patient on theophylline will begin ciprofloxacin. What should the NP do? - ANSWER Reduce the theophylline dose A COPD patient receives inhaled glucocorticoid and LABA. Which statement shows understanding? - ANSWER "The glucocorticoid is used as prophylaxis to prevent exacerbations." A patient with niacin deficiency should report which side effects? - ANSWER Flushing, dizziness, and nausea A patient using bisacodyl laxatives for years is unsure how to stop. What do you tell them? - ANSWER Stop taking the laxative immediately and expect no stool for several days Which statement indicates understanding of bulk-forming laxatives? - ANSWER "I should take each dose with a full glass of water." How should a patient take antacids with cimetidine? - ANSWER "Take the antacid 1 hour after the ranitidine." A gout patient taking colchicine plus simvastatin—what should the NP consider? - ANSWER Potential risk of muscle injury when simvastatin is taken with colchicine Teaching allopurinol + colchicine: what do you tell the patient? - ANSWER "You will take both drugs initially and then stop taking the colchicine." A patient starting glipizide should be warned of what adverse effect? - ANSWER Weight gain When should insulin glargine be administered? - ANSWER Once daily at bedtime Teaching about methimazole for Graves disease: Which statement shows understanding? - ANSWER "I should report a sore throat or fever if either occurs." A pregnant patient refuses hypothyroid medication. What do you explain? - ANSWER Neuropsychologic deficits in the fetus can occur if the condition is not treated A woman with Graves disease trying to conceive asks about treatment. What do you tell her? - ANSWER Change to propylthiouracil until the second trimester Promethazine ordered for an 18-month-old—what should be considered? - ANSWER Reconsider order due to respiratory depression risk in children A woman beginning long-term glucocorticoids should take what to prevent osteoporosis? - ANSWER Calcium and vitamin D supplements Which vaccine should NOT be given to an immunocompromised child? - ANSWER Varicella virus vaccine A child has 103°F fever the day after MMR. What should the NP do? - ANSWER Reassure the parent that fever can occur with the MMR vaccine. Which vaccines should an immunocompromised child on high-dose steroids receive? - ANSWER DTaP and IPV only What is a drug agonist? - ANSWER A drug that interacts directly with receptor sites to mimic natural chemicals