NSG 552 PSYCHO PHARMACOLOGY
WILKES EXAM 3 STUDY GUIDE
QUESTIONS WITH 100% CORRECT
ANSWERS L LATEST VERSION 2025/2026.
First Line Treatments for alcohol use disorder (according to Study Guide & Dynamed) -
ANS naltrexone and acamprosate
Second Line Treatments for alcohol use disorder (according to study guide but not dynamed) -
ANS Disulfuram and Bupropion (not FDA approved for ETOH but second line according to
study guide)
Second Line Treatment for alcohol use disorder (according to Dynamed) - ANS Disulfuram
Other off label medications for alcohol use disorder according to Dynamed - ANS Topiramate,
gabapentin, baclofen
Other off label medications for alcohol use disorder according to Stahl's - ANS Topiramate,
ondansetron
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, MOA of Naltrexone - ANS Opioid Receptor Antagonist
MOA of Acamprosate - ANS - weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
MOA of Disulfuram - ANS inhibits enzyme (aldehyde dehydrogenase) in the liver
Bupropions role in alcohol use disorder - ANS Can diminish cravings for etoh, treat underlying
anxiety/depression
Safety Risk associated with bupropion and etoh - ANS bupropion increases the risk of
seizures in those going through etoh withdrawal
s/s ETOH intoxication - ANS impaired fine motor control, impaired judgement and
coordination, ataxic gait, poor balance, lethargy, difficulty sitting upright, difficulty with memory
and sitting upright, N/V, coma in levels 300mg/dL and over with respiratory depression and
death possible
S/S of etoh withdrawal - ANS Mild: insomnia, irritability, hand tremor
Moderate: autonomic hyperactivity (diaphoresis, tachycardia, HTN), fever
Severe: seizures (12-48 hours post consumption), hallucinations, Delirium Tremens
Delirium Tremens - ANS 48-96 hours after last etoh consumption includes anxiety, anorexia,
nausea/vomiting, psychomotor agitation
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
WILKES EXAM 3 STUDY GUIDE
QUESTIONS WITH 100% CORRECT
ANSWERS L LATEST VERSION 2025/2026.
First Line Treatments for alcohol use disorder (according to Study Guide & Dynamed) -
ANS naltrexone and acamprosate
Second Line Treatments for alcohol use disorder (according to study guide but not dynamed) -
ANS Disulfuram and Bupropion (not FDA approved for ETOH but second line according to
study guide)
Second Line Treatment for alcohol use disorder (according to Dynamed) - ANS Disulfuram
Other off label medications for alcohol use disorder according to Dynamed - ANS Topiramate,
gabapentin, baclofen
Other off label medications for alcohol use disorder according to Stahl's - ANS Topiramate,
ondansetron
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, MOA of Naltrexone - ANS Opioid Receptor Antagonist
MOA of Acamprosate - ANS - weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
MOA of Disulfuram - ANS inhibits enzyme (aldehyde dehydrogenase) in the liver
Bupropions role in alcohol use disorder - ANS Can diminish cravings for etoh, treat underlying
anxiety/depression
Safety Risk associated with bupropion and etoh - ANS bupropion increases the risk of
seizures in those going through etoh withdrawal
s/s ETOH intoxication - ANS impaired fine motor control, impaired judgement and
coordination, ataxic gait, poor balance, lethargy, difficulty sitting upright, difficulty with memory
and sitting upright, N/V, coma in levels 300mg/dL and over with respiratory depression and
death possible
S/S of etoh withdrawal - ANS Mild: insomnia, irritability, hand tremor
Moderate: autonomic hyperactivity (diaphoresis, tachycardia, HTN), fever
Severe: seizures (12-48 hours post consumption), hallucinations, Delirium Tremens
Delirium Tremens - ANS 48-96 hours after last etoh consumption includes anxiety, anorexia,
nausea/vomiting, psychomotor agitation
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
