NU578 - UNIT 1 EXAM QUESTIONS WITH
100% CORRECT ANSWERS LATEST
VERSION 2025/2026.
Schedule I - ANS Drugs in this schedule have no accepted medical use in the United States
and have a high abuse potential.
Examples are heroin, marijuana, LSD, peyote, etc.
Schedule II - ANS Drugs in this schedule have a high abuse potential with severe psychic or
physical dependence liability. Included are certain narcotic analgesics, stimulants, and
depressant drugs.
Examples are opium, morphine, codeine, hydromorphone, methadone, meperidine, oxycodone,
anileridine, cocaine, amphetamine, methamphetamine, phenmetrazine, methylphenidate,
amobarbital, pentobarbital, secobarbital, methaqualone, and phencyclidine.
Schedule III - ANS Drugs in this schedule have an abuse potential less than those in Schedules
I and II and include compounds containing limited quantities of certain narcotic analgesic drugs,
and other drugs such as barbiturates, glutethimide, methyprylon, and chlorphentemine.
Any suppository dosage form containing amobarbital, secobarbital, or pentobarbital is in this
schedule.
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
,Schedule IV - ANS Drugs in this schedule have an abuse potential less than those listed in
Schedule III and include such drugs as barbital, phenobarbital, chloral hydrate, ethchlorvynol,
meprobabmate, chlordizepoxide, diazepam, oxazepam, chloroazepate, flurazepam, etc.
Schedule V - ANS Drugs in this schedule have an abuse potential less than those listed in
Schedule IV and consist primarily of preparations containing limited quantities of certain
narcotic analgesic drugs used for antitussive and antidiarrheal purposes.
Absorption - ANS Process of drug movement from its site of administration into the blood
Most common mechanism for drug absorption - ANS passive diffusion
First-pass effect
(presystemic metabolism) - ANS Rapid hepatic inactivation of certain oral drugs
drug is metabolized (chemically altered) as it passes through either 1) gut wall, and 2) liver.
Distribution - ANS drug movement from the blood to the interstitial space of tissues and from
there into cells
Barriers to distribution - ANS - Blood brain barrier
- Placenta
Physiologic Factors Affecting Distribution - ANS - Perfusion
- Binding of drug to plasma protein
- Specialized Distribution Barriers
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, Albumin - ANS Binds acidic drugs
Protein (albumin) binding - ANS Prevents bound drug molecules from leaving the
bloodstream
Prolongs the distribution phase (Increases half-life)
alpha-1 acid glycoprotein - ANS Binds basic drugs
Reservoir effect - ANS
Blood-Brain Barrier (BBB) - ANS no intercellular pores between brain capillary endothelial
membranes due to the presence of tight junctions between cells
To gain access to the brain from the capillaries, drugs must - ANS 1) diffuse across cells (lipid-
soluble,
nonionized form)
or
2) or be actively transported by a carrier
Placental Barrier - ANS Transfer of drugs is relatively slow with the
equilibration time between maternal blood and fetal tissues estimated at about 15 minutes for
some drugs and almost an hour for other drugs.
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
100% CORRECT ANSWERS LATEST
VERSION 2025/2026.
Schedule I - ANS Drugs in this schedule have no accepted medical use in the United States
and have a high abuse potential.
Examples are heroin, marijuana, LSD, peyote, etc.
Schedule II - ANS Drugs in this schedule have a high abuse potential with severe psychic or
physical dependence liability. Included are certain narcotic analgesics, stimulants, and
depressant drugs.
Examples are opium, morphine, codeine, hydromorphone, methadone, meperidine, oxycodone,
anileridine, cocaine, amphetamine, methamphetamine, phenmetrazine, methylphenidate,
amobarbital, pentobarbital, secobarbital, methaqualone, and phencyclidine.
Schedule III - ANS Drugs in this schedule have an abuse potential less than those in Schedules
I and II and include compounds containing limited quantities of certain narcotic analgesic drugs,
and other drugs such as barbiturates, glutethimide, methyprylon, and chlorphentemine.
Any suppository dosage form containing amobarbital, secobarbital, or pentobarbital is in this
schedule.
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
,Schedule IV - ANS Drugs in this schedule have an abuse potential less than those listed in
Schedule III and include such drugs as barbital, phenobarbital, chloral hydrate, ethchlorvynol,
meprobabmate, chlordizepoxide, diazepam, oxazepam, chloroazepate, flurazepam, etc.
Schedule V - ANS Drugs in this schedule have an abuse potential less than those listed in
Schedule IV and consist primarily of preparations containing limited quantities of certain
narcotic analgesic drugs used for antitussive and antidiarrheal purposes.
Absorption - ANS Process of drug movement from its site of administration into the blood
Most common mechanism for drug absorption - ANS passive diffusion
First-pass effect
(presystemic metabolism) - ANS Rapid hepatic inactivation of certain oral drugs
drug is metabolized (chemically altered) as it passes through either 1) gut wall, and 2) liver.
Distribution - ANS drug movement from the blood to the interstitial space of tissues and from
there into cells
Barriers to distribution - ANS - Blood brain barrier
- Placenta
Physiologic Factors Affecting Distribution - ANS - Perfusion
- Binding of drug to plasma protein
- Specialized Distribution Barriers
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, Albumin - ANS Binds acidic drugs
Protein (albumin) binding - ANS Prevents bound drug molecules from leaving the
bloodstream
Prolongs the distribution phase (Increases half-life)
alpha-1 acid glycoprotein - ANS Binds basic drugs
Reservoir effect - ANS
Blood-Brain Barrier (BBB) - ANS no intercellular pores between brain capillary endothelial
membranes due to the presence of tight junctions between cells
To gain access to the brain from the capillaries, drugs must - ANS 1) diffuse across cells (lipid-
soluble,
nonionized form)
or
2) or be actively transported by a carrier
Placental Barrier - ANS Transfer of drugs is relatively slow with the
equilibration time between maternal blood and fetal tissues estimated at about 15 minutes for
some drugs and almost an hour for other drugs.
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
