PHM 431 FINAL: PRACTICE EXAM
QUESTIONS WITH 100% CORRECT
ANSWERS LATEST VERSION 2025/2026.
Although there are many types of nicotinic acetylcholine receptors in the brain, the rewarding
effects produced by chronic cigarette smoking are most probably mediate at:
a. Postsynaptic alpha-3-beta-4 receptors
b. Postsynaptic alpha-4-beta-2 receptors
c. Presynaptic alpha-7 receptors
d. Presynaptic alpha-4-beta-2 receptors - ANS Presynaptic alpha-7 receptors
Amphetamines increase attention and awareness by the user of his or her environment. The
brain region affected by amphetamine that mediates this response is the:
a. Nucleus accumbens
b. Prefrontal cortex
c. Locus ceruleus
d. Hypothalamus - ANS Locus ceruleus
Which of the following is an enzyme expressed in the liver that is responsible for degradation of
catecholamines found in the diet and absorbed from the small intestine?
a. Cytochrome P450
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, b. Dopamine-beta-hydroxylase
c. Tyrosine hydroxylase
d. Monoamine oxidase - ANS Monoamine oxidase
A 24-year-old graduate student has died of a drug overdose. Postmortem blood samples reveal
the presence of the following chemicals: methylecgonidine, benzoylecognidine, and ecgonidine
methylester. The drug overdose was caused by:
a. Cocaine hydrochloride
b. Crack cocaine
c. Cocaine hydrochloride/alcohol
d. Methylenedioxymethamphetamine - ANS Crack cocaine
Which of the following drugs is a substrate for the vesicular monoamine transporter?
a. Methylphenidate
b. Cocaine
c. Methamphetamine
d. LSD-25 - ANS Methamphetamine
Which of the following is not a target for the action of caffeine?
a. Phosphodiesterase
b. Adenosine A1 receptors
c. Adenosine A2 receptors
d. Dopamine-beta-hydroxylase - ANS Dopamine-beta-hydroxylase
Disruption of processing of sensory information in the thalamus is a mechanism of action of
which of the following drugs?
a. Cocaine
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
QUESTIONS WITH 100% CORRECT
ANSWERS LATEST VERSION 2025/2026.
Although there are many types of nicotinic acetylcholine receptors in the brain, the rewarding
effects produced by chronic cigarette smoking are most probably mediate at:
a. Postsynaptic alpha-3-beta-4 receptors
b. Postsynaptic alpha-4-beta-2 receptors
c. Presynaptic alpha-7 receptors
d. Presynaptic alpha-4-beta-2 receptors - ANS Presynaptic alpha-7 receptors
Amphetamines increase attention and awareness by the user of his or her environment. The
brain region affected by amphetamine that mediates this response is the:
a. Nucleus accumbens
b. Prefrontal cortex
c. Locus ceruleus
d. Hypothalamus - ANS Locus ceruleus
Which of the following is an enzyme expressed in the liver that is responsible for degradation of
catecholamines found in the diet and absorbed from the small intestine?
a. Cytochrome P450
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, b. Dopamine-beta-hydroxylase
c. Tyrosine hydroxylase
d. Monoamine oxidase - ANS Monoamine oxidase
A 24-year-old graduate student has died of a drug overdose. Postmortem blood samples reveal
the presence of the following chemicals: methylecgonidine, benzoylecognidine, and ecgonidine
methylester. The drug overdose was caused by:
a. Cocaine hydrochloride
b. Crack cocaine
c. Cocaine hydrochloride/alcohol
d. Methylenedioxymethamphetamine - ANS Crack cocaine
Which of the following drugs is a substrate for the vesicular monoamine transporter?
a. Methylphenidate
b. Cocaine
c. Methamphetamine
d. LSD-25 - ANS Methamphetamine
Which of the following is not a target for the action of caffeine?
a. Phosphodiesterase
b. Adenosine A1 receptors
c. Adenosine A2 receptors
d. Dopamine-beta-hydroxylase - ANS Dopamine-beta-hydroxylase
Disruption of processing of sensory information in the thalamus is a mechanism of action of
which of the following drugs?
a. Cocaine
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
