PHM 350 - EXAM 3 QUESTIONS WITH
100% CORRECT ANSWERS LATEST
VERSION 2025/2026.
A drug which induces sedation and is used in the treatment of muscle spasms and for which
flumazenil (ROMAZICON) is a pharmacological antagonist:
A. Imipramine (TOFRANIL)
B. Diazepam (VALIUM)
C. Buspirone (BUSPAR)
D. Haloperidol (HALDOL)
E. A and C above - ANS B. Diazepam (VALIUM)
The first person in your clinic one morning is the patient of one of your practice partners. He,
the patient, is being treated for depression and has had a blood glucose assessment: he is
clearly hyperglycemic (although he has not previously been diagnosed as being diabetic). Which
of the following drugs (used to treat his depression) has caused this hyperglycemic state?
A. Aripiprazole (ABILIFY)
B. Imipramine (TOFRANIL)
C. Duloxetine (CYMBALTA)
D. Sertraline (ZOLOFT)
E. A and C above - ANS A. Aripiprazole (ABILIFY)
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
,Which of the following drugs is used in the treatment of insomnia and would also be expected
to be useful in treatment of anxiety (although it is not usually used for that purpose)?
A. Buspirone (BUSPAR)
B. Ramelteon (ROZEREM)
C. Doxepin (SILENOR)
D. Triazolam (HALCION)
E. A and C above - ANS D. Triazolam (HALCION)
Which of the following drugs is used to treat anxiety but does not produce sedation or sleep?
A. Doxepin (SILENOR)
B. Flumazenil (ROMAZICON)
C. Zolpidem (AMBIEN)
D. Buspirone (BUSPAR)
E. A and C above - ANS D. Buspirone (BUSPAR)
Opiate receptor agonists:
A. Acts as analgesics by blocking the formation of prostaglandins at the site of the wound
B. Block neurotransmission in central pain pathways
C. Reduce intracranial pressure and is therefore useful in treatment of head injuries
D. Increase the motility of the gastrointestinal tract
E. A and C above - ANS B. Block neurotransmission in central pain pathways
Which of the following drugs inhibits reuptake of norepinephrine and of serotonin (into
noradrenergic neurons and serotonergic neurons respectively), is used to treat depression, but
is not a "tricyclic antidepressant"?
A. Duloxetine (CYMBALTA)
B. Imipramine (TOFRANIL)
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
,C. Bupropion (WELLBUTRIN)
D. Aripiprazole (ABILIFY)
E. A and C above - ANS A. Duloxetine (CYMBALTA)
LevoDOPA or l-DOPA is used to treat Parkinson's Disease. This drug
A. May cause psychosis as a side effect
B. Has high affinity for dopamine receptors in the striatum
C. Is taken up selectively (preferentially) by dopaminergic neurons of the nigro-striatal system
D. Produces hyperprolactinemia as a side effect
E. A and C above - ANS A. May cause psychosis as a side effect
Naloxone (NARCAN)
A. Will induce withdrawal response in individuals being chronically treated with morphine
(ASTROMORPH)
B. Is an opiate receptor agonist
C. Is used to reverse the effects of acute morphine overdose
D. Is used as an anti-depressant because it activates serotonin receptors
E. A and C above - ANS E. A and C above
Which of the following drugs or classes of drug produce tardive dyskinesia and similar
movement disorders when administered repeatedly at therapeutic doses (i.e. administered as
intended for therapeutic benefit)?
A. Haloperidol (HALDOL)
B. Amitriptyline (ELAVIL)
C. Paroxetine (PAXIL)
D. Methadone (DOLOPHINE)
E. Midazolam (VERSED) - ANS A. Haloperidol (HALDOL)
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, Carbidopa is used with levodopa in treatment of Parkinson's Disease because:
A. Carbidopa reduces the proportion of each dose of levodopa being converted to
norepinephrine in postganglionic sympathetic neurons
B. Carbidopa reduces levodopa uptake into norepinephrine synthesizing and secreting neurons
in the central nervous system
C. Carbidopa increases the proportion of each dose of levodopa being converted to
norepinephrine in central noradrenergic neurons
D. Carbidopa reduces the potential psychosis-inducing effects of levodopa
E. A and C above - ANS E. A and C above
Which of the following competes for the same binding site as phenobarbital (LUMINAL)?
A. Flumazenil (ROMAZICON)
B. Imipramine (TOFRANIL)
C. Diazepam (VALIUM)
D. Thiopental (PENTOTHAL)
E. None of the above - ANS D. Thiopental (PENTOTHAL)
The problem with using levodopa alone in the treatment of Parkinson's Disease is that:
A. It is not effective (i.e. does not have therapeutic benefit)
B. Much of each dose of levodopa does not enter the brain
C. There is a high possibility that psychosis will develop
D. Release of levodopa from dopaminergic neurons in the brain can not be controlled
E. None of the above - ANS B. Much of each dose of levodopa does not enter the brain
The first person in your clinic one morning is the patient of one of your practice partners and is
being treated for depression. You note that since her last visit to the clinic she has gained
4 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
100% CORRECT ANSWERS LATEST
VERSION 2025/2026.
A drug which induces sedation and is used in the treatment of muscle spasms and for which
flumazenil (ROMAZICON) is a pharmacological antagonist:
A. Imipramine (TOFRANIL)
B. Diazepam (VALIUM)
C. Buspirone (BUSPAR)
D. Haloperidol (HALDOL)
E. A and C above - ANS B. Diazepam (VALIUM)
The first person in your clinic one morning is the patient of one of your practice partners. He,
the patient, is being treated for depression and has had a blood glucose assessment: he is
clearly hyperglycemic (although he has not previously been diagnosed as being diabetic). Which
of the following drugs (used to treat his depression) has caused this hyperglycemic state?
A. Aripiprazole (ABILIFY)
B. Imipramine (TOFRANIL)
C. Duloxetine (CYMBALTA)
D. Sertraline (ZOLOFT)
E. A and C above - ANS A. Aripiprazole (ABILIFY)
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
,Which of the following drugs is used in the treatment of insomnia and would also be expected
to be useful in treatment of anxiety (although it is not usually used for that purpose)?
A. Buspirone (BUSPAR)
B. Ramelteon (ROZEREM)
C. Doxepin (SILENOR)
D. Triazolam (HALCION)
E. A and C above - ANS D. Triazolam (HALCION)
Which of the following drugs is used to treat anxiety but does not produce sedation or sleep?
A. Doxepin (SILENOR)
B. Flumazenil (ROMAZICON)
C. Zolpidem (AMBIEN)
D. Buspirone (BUSPAR)
E. A and C above - ANS D. Buspirone (BUSPAR)
Opiate receptor agonists:
A. Acts as analgesics by blocking the formation of prostaglandins at the site of the wound
B. Block neurotransmission in central pain pathways
C. Reduce intracranial pressure and is therefore useful in treatment of head injuries
D. Increase the motility of the gastrointestinal tract
E. A and C above - ANS B. Block neurotransmission in central pain pathways
Which of the following drugs inhibits reuptake of norepinephrine and of serotonin (into
noradrenergic neurons and serotonergic neurons respectively), is used to treat depression, but
is not a "tricyclic antidepressant"?
A. Duloxetine (CYMBALTA)
B. Imipramine (TOFRANIL)
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
,C. Bupropion (WELLBUTRIN)
D. Aripiprazole (ABILIFY)
E. A and C above - ANS A. Duloxetine (CYMBALTA)
LevoDOPA or l-DOPA is used to treat Parkinson's Disease. This drug
A. May cause psychosis as a side effect
B. Has high affinity for dopamine receptors in the striatum
C. Is taken up selectively (preferentially) by dopaminergic neurons of the nigro-striatal system
D. Produces hyperprolactinemia as a side effect
E. A and C above - ANS A. May cause psychosis as a side effect
Naloxone (NARCAN)
A. Will induce withdrawal response in individuals being chronically treated with morphine
(ASTROMORPH)
B. Is an opiate receptor agonist
C. Is used to reverse the effects of acute morphine overdose
D. Is used as an anti-depressant because it activates serotonin receptors
E. A and C above - ANS E. A and C above
Which of the following drugs or classes of drug produce tardive dyskinesia and similar
movement disorders when administered repeatedly at therapeutic doses (i.e. administered as
intended for therapeutic benefit)?
A. Haloperidol (HALDOL)
B. Amitriptyline (ELAVIL)
C. Paroxetine (PAXIL)
D. Methadone (DOLOPHINE)
E. Midazolam (VERSED) - ANS A. Haloperidol (HALDOL)
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, Carbidopa is used with levodopa in treatment of Parkinson's Disease because:
A. Carbidopa reduces the proportion of each dose of levodopa being converted to
norepinephrine in postganglionic sympathetic neurons
B. Carbidopa reduces levodopa uptake into norepinephrine synthesizing and secreting neurons
in the central nervous system
C. Carbidopa increases the proportion of each dose of levodopa being converted to
norepinephrine in central noradrenergic neurons
D. Carbidopa reduces the potential psychosis-inducing effects of levodopa
E. A and C above - ANS E. A and C above
Which of the following competes for the same binding site as phenobarbital (LUMINAL)?
A. Flumazenil (ROMAZICON)
B. Imipramine (TOFRANIL)
C. Diazepam (VALIUM)
D. Thiopental (PENTOTHAL)
E. None of the above - ANS D. Thiopental (PENTOTHAL)
The problem with using levodopa alone in the treatment of Parkinson's Disease is that:
A. It is not effective (i.e. does not have therapeutic benefit)
B. Much of each dose of levodopa does not enter the brain
C. There is a high possibility that psychosis will develop
D. Release of levodopa from dopaminergic neurons in the brain can not be controlled
E. None of the above - ANS B. Much of each dose of levodopa does not enter the brain
The first person in your clinic one morning is the patient of one of your practice partners and is
being treated for depression. You note that since her last visit to the clinic she has gained
4 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
