PHA 317 Quiz 10 & 11 Questions and Answers Latest Update 2025/2026
Time taken for 5% of a drug to decompose by first-order kinetics is: - Answers 0.05/k1
The following data were obtained for the hydrolysis of homatropin (which follows first order
kinetics) in 0.226 mol/L HCl at 90 degrees C - Answers 13.2 hr
For a single step (elementary) reaction, the molecularity and order are the same - Answers True
The plasma level of an orally administered tablet depends on:
i. The rate of tablet disintegration
ii. The rate of dissolution of the drug - Answers Both i and ii are correct
The hydraulic degradation of acetylsalicylic acid in its aqueous suspension follows which kind
of kinetic? - Answers Pseudo zero-order
In a zero order reaction:
i. The rate of decomposition is dependent on the concentration of one of the reactants
ii. The rate of decomposition is independent on the concentration of any of the reactants
iii. A plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k - Answers Only ii is correct
Prout-Tompkins Model best describes - Answers A solid state reaction
A base catalyzed hydrolysis of an ester such as chloramphenicol palmitate can exhibit:
i. a second-order kinetics only if the concentration of both -ester and base are changing
ii. a pseudo first-order kinetics if the concentration of the hydroxyl ion is maintained constant
iii. a pseudo first-order kinetics if the concentration of both ester and base are maintained
constant
iv. a first-order kinetics if the concentration of the hydroxyl ion is maintained constant
v. zero-order kinetics if the concentration of both ester and base are maintained constant -
Answers Only I, ii, and iii are correct
Which of the following is not a characteristic of solid state reaction? - Answers It happens in a
homogenous medium
It is not conceivable for a reaction to have zero or fractional molecularity - Answers True
In a second order reaction:
, i. The rate of reaction depends on the concentration of two reacting species
ii. A plot of time (as abscissa) against (a0-a)/(aa0) (as ordinate) is linear with a slope equal to
1/k2
iii. The half-life is independent of the concentration
iv. The unit of k is concentration/time - Answers Only i and ii are correct
Lineweaver-Burke equation for an enzymatic reaction is useful for:
i. Determining the constant Km in Michaelis Menton equation
ii. Determining the constant Vmax in Michaelis Menton equation
iii. Determining only the constant Km or Vmax but not simultaneously in Michaelis Menton
equation - Answers Both i and ii are correct
In a study of the hydrolysis of a drug in an aqueous solution a plot of logarithm of the amount of
drug remaining (as ordinate) against time (abscissa) is linear:
i. The reaction is zero order
ii. The slope is -2.303/k
iii. The unit of k is concentration-1 time -1
iv. The half-life does not depend on the initial concentration of reactant - Answers Only iv is
correct
The half-life of a drug in a solution is 30 minutes. What would be the concentration of the drug
in the solution after 90 minutes? - Answers 12.50% of the initial concentration
Select the correct order of degradation of a drug by hydrolysis - Answers Pseudo first-order
The ratio or speed of a process (a physical or chemical change) can be defined by:
i. The rate at which the concentration of a species undergoing the change decreases
ii. The rate at which the concentration of the resulting species increases with time.
iii. The rate at which the concentration of the resulting species decreases with time - Answers
Both i and ii are correct
In a zero order reaction:
i. The half-life is equal to 0.693/k
ii. The unit of k is concentration/time
Time taken for 5% of a drug to decompose by first-order kinetics is: - Answers 0.05/k1
The following data were obtained for the hydrolysis of homatropin (which follows first order
kinetics) in 0.226 mol/L HCl at 90 degrees C - Answers 13.2 hr
For a single step (elementary) reaction, the molecularity and order are the same - Answers True
The plasma level of an orally administered tablet depends on:
i. The rate of tablet disintegration
ii. The rate of dissolution of the drug - Answers Both i and ii are correct
The hydraulic degradation of acetylsalicylic acid in its aqueous suspension follows which kind
of kinetic? - Answers Pseudo zero-order
In a zero order reaction:
i. The rate of decomposition is dependent on the concentration of one of the reactants
ii. The rate of decomposition is independent on the concentration of any of the reactants
iii. A plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k - Answers Only ii is correct
Prout-Tompkins Model best describes - Answers A solid state reaction
A base catalyzed hydrolysis of an ester such as chloramphenicol palmitate can exhibit:
i. a second-order kinetics only if the concentration of both -ester and base are changing
ii. a pseudo first-order kinetics if the concentration of the hydroxyl ion is maintained constant
iii. a pseudo first-order kinetics if the concentration of both ester and base are maintained
constant
iv. a first-order kinetics if the concentration of the hydroxyl ion is maintained constant
v. zero-order kinetics if the concentration of both ester and base are maintained constant -
Answers Only I, ii, and iii are correct
Which of the following is not a characteristic of solid state reaction? - Answers It happens in a
homogenous medium
It is not conceivable for a reaction to have zero or fractional molecularity - Answers True
In a second order reaction:
, i. The rate of reaction depends on the concentration of two reacting species
ii. A plot of time (as abscissa) against (a0-a)/(aa0) (as ordinate) is linear with a slope equal to
1/k2
iii. The half-life is independent of the concentration
iv. The unit of k is concentration/time - Answers Only i and ii are correct
Lineweaver-Burke equation for an enzymatic reaction is useful for:
i. Determining the constant Km in Michaelis Menton equation
ii. Determining the constant Vmax in Michaelis Menton equation
iii. Determining only the constant Km or Vmax but not simultaneously in Michaelis Menton
equation - Answers Both i and ii are correct
In a study of the hydrolysis of a drug in an aqueous solution a plot of logarithm of the amount of
drug remaining (as ordinate) against time (abscissa) is linear:
i. The reaction is zero order
ii. The slope is -2.303/k
iii. The unit of k is concentration-1 time -1
iv. The half-life does not depend on the initial concentration of reactant - Answers Only iv is
correct
The half-life of a drug in a solution is 30 minutes. What would be the concentration of the drug
in the solution after 90 minutes? - Answers 12.50% of the initial concentration
Select the correct order of degradation of a drug by hydrolysis - Answers Pseudo first-order
The ratio or speed of a process (a physical or chemical change) can be defined by:
i. The rate at which the concentration of a species undergoing the change decreases
ii. The rate at which the concentration of the resulting species increases with time.
iii. The rate at which the concentration of the resulting species decreases with time - Answers
Both i and ii are correct
In a zero order reaction:
i. The half-life is equal to 0.693/k
ii. The unit of k is concentration/time
