Advanced Clinical Chemistry Final
ACTUAL UPDATED QUESTIONS AND
CORRECT ANSWERS
The parent substance in the biosynthesis of androgens and estrogens is: - CORRECT
ANSWERS✅✅cholesterol
The most potent estrogen, and the substance considered to be the true ovarian hormone, is: -
CORRECT ANSWERS✅✅estradiol
What disease/syndrome is associated with using aspirin in young children? - CORRECT
ANSWERS✅✅Reye's syndrome
Pre-eclampsia is associated with an increase in blood pressure and a decrease in: -
CORRECT ANSWERS✅✅glomerular filtration rate
A fairly common inborn error of metabolism that has an incidence of 1 in 2400 live births is:
- CORRECT ANSWERS✅✅cystic fibrosis
Measurement of the activity of the enzyme ___________________ in amniotic fluid
confirms the prenatal diagnosis of neural tube defects and anencephaly. - CORRECT
ANSWERS✅✅Acetylcholinesterase
The biologically most active, naturally occurring androgen is: - CORRECT
ANSWERS✅✅testosterone
Androgen secretion by the testes is stimulated by: - CORRECT ANSWERS✅✅luteinizing
hormone (LH)
What are the "triple markers" used to diagnose Down's syndrome in utero? - CORRECT
ANSWERS✅✅Alpha-fetoprotein (AFP), beta-hCG, estriol
,The Aminostat agglutination test is performed on amniotic fluid from pregnant women to
detect the presence of: - CORRECT ANSWERS✅✅phosphatidylglycerol
This is the major lipid component of pulmonary surfactant to confirm FLM: - CORRECT
ANSWERS✅✅lecithin (DCPG)
What lipid remains in a steady level state in amniotic fluid during the entire course of a
pregnancy? - CORRECT ANSWERS✅✅sphingomyelin
Chronic fetal metabolic distress is demonstrated by: - CORRECT ANSWERS✅✅decreased
urinary estriol excretion and decreased maternal serum estriol
There is no hormone from what class of chemicals? - CORRECT
ANSWERS✅✅carbohydrates
Synthetic secretion of the adrenal gland is stimulated by what? - CORRECT
ANSWERS✅✅cosyntropin (ACTH)
Measurement of what urinary compound would be the most useful for diagnosis of a
pheochromocytoma? - CORRECT ANSWERS✅✅metanephrines
A genetic disorder causing a deficiency of certain enzymes in the synthetic pathways leading
to cortisol and aldosterone production is referred to as: - CORRECT
ANSWERS✅✅congenital adrenal hyperplasia
The definitive diagnosis of primary adrenal insufficiency requires demonstration of: -
CORRECT ANSWERS✅✅impaired response to ACTH (cosyntropin) stimulation
A 25-year-old woman, who was 6 months postpartun (after childbirth), visits her physician
with complaints of tiredness, always feeling cold, muscle weakness, menorrhagia (heavy
menstrual bleeding), and weight gain. Her physician noted very dry skin.
Lab results show: normal plasma electrolytes, glucose, BUN, and creatinine; total T4 is on
the low side of normal with increased TSH; T3 uptake is low.
, Why is TSH elevated? - CORRECT ANSWERS✅✅normal pituitary response to primary
hypothyroidism
A 12-year-old girl collapsed at the breakfast table. She has been urinating and drinking more
than usual, plus getting up at night to urinate. Lab results show the following:
Plasma electrolytes: low sodium and chloride with high potassium, low bicarbonate; 3x
normal glucose; high BUN with normal creatinine.
If a blood gas was drawn on this patient, what would the pH be? - CORRECT
ANSWERS✅✅Acidotic
The major fraction of organic iodine circulating in the blood is: - CORRECT
ANSWERS✅✅tetraiodothyronine
What is the direct signal for the release of T4 from the thyroid gland? - CORRECT
ANSWERS✅✅thyroid-stimulating hormone (TSH)
A two-year-old with decreased serum T4 is described as being somewhat dwarfed, stocky,
and overweight and having coarse features. The most informative additional laboratory test
would be serum: - CORRECT ANSWERS✅✅thyroid-stimulating hormone (TSH)
What is monitored in the diagnosis of Grave's disease? - CORRECT ANSWERS✅✅thyroid-
stimulating immunoglobulin titer
True or false: When taken by a euthyroid individual, oral contraceptives will have an
increasing effect on thyroxine binding globulin. - CORRECT ANSWERS✅✅True
A 45-year-old woman comes into the clinic with the following clinical symptoms: flushed
cheeks, difficulty breathing, and very rapid heart rate. Her eyes are very prominent. Her lab
reports show high T3 and T4. What should her doctor be most concerned about? - CORRECT
ANSWERS✅✅Associated life-threatening cardiac irregularities
ACTUAL UPDATED QUESTIONS AND
CORRECT ANSWERS
The parent substance in the biosynthesis of androgens and estrogens is: - CORRECT
ANSWERS✅✅cholesterol
The most potent estrogen, and the substance considered to be the true ovarian hormone, is: -
CORRECT ANSWERS✅✅estradiol
What disease/syndrome is associated with using aspirin in young children? - CORRECT
ANSWERS✅✅Reye's syndrome
Pre-eclampsia is associated with an increase in blood pressure and a decrease in: -
CORRECT ANSWERS✅✅glomerular filtration rate
A fairly common inborn error of metabolism that has an incidence of 1 in 2400 live births is:
- CORRECT ANSWERS✅✅cystic fibrosis
Measurement of the activity of the enzyme ___________________ in amniotic fluid
confirms the prenatal diagnosis of neural tube defects and anencephaly. - CORRECT
ANSWERS✅✅Acetylcholinesterase
The biologically most active, naturally occurring androgen is: - CORRECT
ANSWERS✅✅testosterone
Androgen secretion by the testes is stimulated by: - CORRECT ANSWERS✅✅luteinizing
hormone (LH)
What are the "triple markers" used to diagnose Down's syndrome in utero? - CORRECT
ANSWERS✅✅Alpha-fetoprotein (AFP), beta-hCG, estriol
,The Aminostat agglutination test is performed on amniotic fluid from pregnant women to
detect the presence of: - CORRECT ANSWERS✅✅phosphatidylglycerol
This is the major lipid component of pulmonary surfactant to confirm FLM: - CORRECT
ANSWERS✅✅lecithin (DCPG)
What lipid remains in a steady level state in amniotic fluid during the entire course of a
pregnancy? - CORRECT ANSWERS✅✅sphingomyelin
Chronic fetal metabolic distress is demonstrated by: - CORRECT ANSWERS✅✅decreased
urinary estriol excretion and decreased maternal serum estriol
There is no hormone from what class of chemicals? - CORRECT
ANSWERS✅✅carbohydrates
Synthetic secretion of the adrenal gland is stimulated by what? - CORRECT
ANSWERS✅✅cosyntropin (ACTH)
Measurement of what urinary compound would be the most useful for diagnosis of a
pheochromocytoma? - CORRECT ANSWERS✅✅metanephrines
A genetic disorder causing a deficiency of certain enzymes in the synthetic pathways leading
to cortisol and aldosterone production is referred to as: - CORRECT
ANSWERS✅✅congenital adrenal hyperplasia
The definitive diagnosis of primary adrenal insufficiency requires demonstration of: -
CORRECT ANSWERS✅✅impaired response to ACTH (cosyntropin) stimulation
A 25-year-old woman, who was 6 months postpartun (after childbirth), visits her physician
with complaints of tiredness, always feeling cold, muscle weakness, menorrhagia (heavy
menstrual bleeding), and weight gain. Her physician noted very dry skin.
Lab results show: normal plasma electrolytes, glucose, BUN, and creatinine; total T4 is on
the low side of normal with increased TSH; T3 uptake is low.
, Why is TSH elevated? - CORRECT ANSWERS✅✅normal pituitary response to primary
hypothyroidism
A 12-year-old girl collapsed at the breakfast table. She has been urinating and drinking more
than usual, plus getting up at night to urinate. Lab results show the following:
Plasma electrolytes: low sodium and chloride with high potassium, low bicarbonate; 3x
normal glucose; high BUN with normal creatinine.
If a blood gas was drawn on this patient, what would the pH be? - CORRECT
ANSWERS✅✅Acidotic
The major fraction of organic iodine circulating in the blood is: - CORRECT
ANSWERS✅✅tetraiodothyronine
What is the direct signal for the release of T4 from the thyroid gland? - CORRECT
ANSWERS✅✅thyroid-stimulating hormone (TSH)
A two-year-old with decreased serum T4 is described as being somewhat dwarfed, stocky,
and overweight and having coarse features. The most informative additional laboratory test
would be serum: - CORRECT ANSWERS✅✅thyroid-stimulating hormone (TSH)
What is monitored in the diagnosis of Grave's disease? - CORRECT ANSWERS✅✅thyroid-
stimulating immunoglobulin titer
True or false: When taken by a euthyroid individual, oral contraceptives will have an
increasing effect on thyroxine binding globulin. - CORRECT ANSWERS✅✅True
A 45-year-old woman comes into the clinic with the following clinical symptoms: flushed
cheeks, difficulty breathing, and very rapid heart rate. Her eyes are very prominent. Her lab
reports show high T3 and T4. What should her doctor be most concerned about? - CORRECT
ANSWERS✅✅Associated life-threatening cardiac irregularities
