Pyc2605 exam preparation HIV and Aids
tool use to SCREEN for HIV - answers ELISA- enzyme linked immunosorbent assay
tool use to diagnose HIV - answers Western blot
steps to the HIV life cycle - answers 1. binding- blocked by entry inh (i.e. enfuvirtide,
selzentry)
2. reverse transcription- blocked by NRTIs and NNRTIs
3. integration- block by integrate inh (i.e. raltegravir)
4. transcription
5. translation
6. viral assembly and maturation- blocked by protease inh
name the protease inh - answers all go through the liver& all w/ food except indinavir &
fosamprenavir
-indinavir (crixivan)
-lopinavir + ritonavir (kaletra)
-nelfinavir (viracept)
-ritonavir (norvir)
-saquinavir (invirase)
-tipranavir (aptivus)
-fosamprenavir (lexiva)
-atazanavir (reyataz)
-darunavir (prezista)
class SE of protease inh - answers -weight gain
-lipodystrophy
-hyperglycemia
-hyperlipidemia
-GI SE (i.e. flatulence, N/V/D)
indinavir - answers crixivan (protease inh)
special note about indinavir (crixivan) - answers -take on an empty stomach "an
individual"
-cause kidney stone "crick crick CRIXIVAN"
-keep in same bottle
lopinavir & ritonavir - answers kaletra (protease inh)
special note about lopinavir & ritonavir (kaletra) - answers -store tabs in RT, soln in
fridge
-ritonavir inc lopinavir's conc
, -has EtOH in it
nelfinavir - answers viracept (protease inh)
special note about nelfinavir (viracept) - answers -very bad diarrhea
ritonavir - answers norvir (protease inh)
special note about ritonavir (norvir) - answers -tabs & soln in RT, caps in fridge
-has EtOH in it
-causes paresthesias
saquinavir - answers invirase (protease inh)
"IN SAQramento"
special note about saquinavir (invirase) - answers -has lactulose in it
-DDI w/ ritonavir: cardiac
-DDI w/ rifampin: hepatotoxicity
tipranavir - answers aptivus (protease inh)
special note about tipranavir (aptivus) - answers -bleeding risk
-sulfa allergy
-has EtOH in it
-take w/ high fat meal "so fat, TIP over"
fosamprenavir - answers lexiva (protease inh)
"LEXus is a FOSSil"
special note about fosamprenavir (lexiva) - answers -bleeding risk
-sulfa allergy
-avoid PPI & H2RA to prevent tx failure
-tk soln on an empty stomach
atazanavir - answers reyataz (protease inh)
"AT RAYnold's" :)
where i wish i was at..
i miss you booboogeez
special note about atazanavir (reyataz) - answers -bleeding risk "bleeding love"
-AV block "raynold makes my heart skip a beat"
-only PI that does not inc lipids
-do not combine w/ Viread and Cipro (inc viread levels)
darunavir - answers prezista (protease inh)
"DAR was the PREZident"
tool use to SCREEN for HIV - answers ELISA- enzyme linked immunosorbent assay
tool use to diagnose HIV - answers Western blot
steps to the HIV life cycle - answers 1. binding- blocked by entry inh (i.e. enfuvirtide,
selzentry)
2. reverse transcription- blocked by NRTIs and NNRTIs
3. integration- block by integrate inh (i.e. raltegravir)
4. transcription
5. translation
6. viral assembly and maturation- blocked by protease inh
name the protease inh - answers all go through the liver& all w/ food except indinavir &
fosamprenavir
-indinavir (crixivan)
-lopinavir + ritonavir (kaletra)
-nelfinavir (viracept)
-ritonavir (norvir)
-saquinavir (invirase)
-tipranavir (aptivus)
-fosamprenavir (lexiva)
-atazanavir (reyataz)
-darunavir (prezista)
class SE of protease inh - answers -weight gain
-lipodystrophy
-hyperglycemia
-hyperlipidemia
-GI SE (i.e. flatulence, N/V/D)
indinavir - answers crixivan (protease inh)
special note about indinavir (crixivan) - answers -take on an empty stomach "an
individual"
-cause kidney stone "crick crick CRIXIVAN"
-keep in same bottle
lopinavir & ritonavir - answers kaletra (protease inh)
special note about lopinavir & ritonavir (kaletra) - answers -store tabs in RT, soln in
fridge
-ritonavir inc lopinavir's conc
, -has EtOH in it
nelfinavir - answers viracept (protease inh)
special note about nelfinavir (viracept) - answers -very bad diarrhea
ritonavir - answers norvir (protease inh)
special note about ritonavir (norvir) - answers -tabs & soln in RT, caps in fridge
-has EtOH in it
-causes paresthesias
saquinavir - answers invirase (protease inh)
"IN SAQramento"
special note about saquinavir (invirase) - answers -has lactulose in it
-DDI w/ ritonavir: cardiac
-DDI w/ rifampin: hepatotoxicity
tipranavir - answers aptivus (protease inh)
special note about tipranavir (aptivus) - answers -bleeding risk
-sulfa allergy
-has EtOH in it
-take w/ high fat meal "so fat, TIP over"
fosamprenavir - answers lexiva (protease inh)
"LEXus is a FOSSil"
special note about fosamprenavir (lexiva) - answers -bleeding risk
-sulfa allergy
-avoid PPI & H2RA to prevent tx failure
-tk soln on an empty stomach
atazanavir - answers reyataz (protease inh)
"AT RAYnold's" :)
where i wish i was at..
i miss you booboogeez
special note about atazanavir (reyataz) - answers -bleeding risk "bleeding love"
-AV block "raynold makes my heart skip a beat"
-only PI that does not inc lipids
-do not combine w/ Viread and Cipro (inc viread levels)
darunavir - answers prezista (protease inh)
"DAR was the PREZident"
