A B
Cholesterol synthesis Glycogen and galactose metabolism
acetyl-CoA x2
α-1,4 bonds
(branching)
1 2 3 4 5 6 7 8 9 10
Thiolase
10
(many cycles)
CoA 9
glycogen (n)
Glycosyl (4:6) 8
acetoacetyl-CoA transferase 7
1
(branching 6
α-1,6 bond conjugated
acetyl-CoA enzyme)
1 2 3 4 5
bilirubin
HMG-CoA synthase
CoA
Steroid hormone synthesis
other primed glycog
β-hydroxy-β-methylglutaryl-CoA glucuronidation
(HMG-CoA) reactions
Zona glomerulosa (8 cycles)
HMG-CoA reductase 2 NADPH glycogenin
UDP-gluco
CoA cholesterol
2 NADP +
dehydrogen
UDP-glucuronate
mevalonate Cholesterol 2 NADH 2N
desmolase
Zona fasciculata and zona reticularis
(multiple 3 ATP
steps) 17α-hydroxylase 17, 20 lyase
3 ADP pregnenolone 17-hydroxypregnenolone dehydroepi
(DHEA)
CO2 3β-hydroxysteroid 3β-hydro
3β-hydroxysteroid
dehydrogenase dehydrogenase dehydrog
isopentenyl pyrophosphate (IPP)
(C5) x3 17α-hydroxylase 17, 20 lyase
Cholesterol synthesis Glycogen and galactose metabolism
acetyl-CoA x2
α-1,4 bonds
(branching)
1 2 3 4 5 6 7 8 9 10
Thiolase
10
(many cycles)
CoA 9
glycogen (n)
Glycosyl (4:6) 8
acetoacetyl-CoA transferase 7
1
(branching 6
α-1,6 bond conjugated
acetyl-CoA enzyme)
1 2 3 4 5
bilirubin
HMG-CoA synthase
CoA
Steroid hormone synthesis
other primed glycog
β-hydroxy-β-methylglutaryl-CoA glucuronidation
(HMG-CoA) reactions
Zona glomerulosa (8 cycles)
HMG-CoA reductase 2 NADPH glycogenin
UDP-gluco
CoA cholesterol
2 NADP +
dehydrogen
UDP-glucuronate
mevalonate Cholesterol 2 NADH 2N
desmolase
Zona fasciculata and zona reticularis
(multiple 3 ATP
steps) 17α-hydroxylase 17, 20 lyase
3 ADP pregnenolone 17-hydroxypregnenolone dehydroepi
(DHEA)
CO2 3β-hydroxysteroid 3β-hydro
3β-hydroxysteroid
dehydrogenase dehydrogenase dehydrog
isopentenyl pyrophosphate (IPP)
(C5) x3 17α-hydroxylase 17, 20 lyase
