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Rheumatology Module 1 Synovial Joint
Classification and Microanatomy -LJM TBL 1 EXAM
WITH COMPLETE QUESTIONS AND CORRECT
VERIFIED ANSWERS LATEST UPDATE JUST
RELEASED THIS YEAR
1(Cell types):
Which cell is responsible for maintaining the extracellular matrix of articular cartilage?
A) Osteoblast
B) Fibroblast
C) Chondrocyte
D) Synoviocyte
E) Osteoclast
C) Chondrocyte
Rationale: Chondrocytes are the main cell of cartilage, maintaining ECM
2 (Disease mechanism):
Which is the earliest event in the pathogenesis of osteoarthritis following joint injury?
A) Osteonecrosis
B) Chondral fracture
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C) Chondrocyte apoptosis
D) Formation of pannus
E) Amyloid deposition
C) Chondrocyte apoptosis
Rationale: Chondrocyte death is an early response to cartilage injury, leading to OA
3 (Visual):
A gross pathology image shows a loose fragment within the knee joint after patella
dislocation. This is most consistent with:
A) Chondral fracture
B) Osteochondral fracture
C) Osteonecrosis
D) Synovitis
E) Gout
B) Osteochondral fracture
Rationale: An osteochondral fracture involves cartilage and bone, often after patellar dislocation
4 (Disease):
A teenager presents with joint pain and MRI reveals a bone fragment separating from the
femoral condyle, with underlying bone sclerosis. Most likely diagnosis?
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A) Osteochondritis dissecans
B) Chondromalacia
C) Osteonecrosis
D) Scurvy
E) Rheumatoid arthritis
A) Osteochondritis dissecans
Rationale: Osteochondritis dissecans = separation of osteochondral fragment, sclerosis in
subchondral bone
Autoimmune Rheumatic Disease: Granular and Clinical
4 (Autoantibody panel):
Which autoantibody is recommended for initial screening in suspected SLE?
A) Anti-CCP
B) Anti-dsDNA
C) Rheumatoid factor
D) Antinuclear antibody (ANA)
E) Anti-RNP
D) Antinuclear antibody (ANA)
Rationale: ANA is sensitive for SLE and is used for initial screening; anti-dsDNA is more specific
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5 (Trap):
Which connective tissue disease is NOT associated with anti-nuclear antibodies as a key
diagnostic marker?
A) Systemic lupus erythematosus
B) Sjögren's syndrome
C) Scleroderma
D) Rheumatoid arthritis
E) Osteoarthritis
E) Osteoarthritis
Rationale: OA is non-inflammatory and not associated with ANAs; the others are autoimmune
4 (Pathogenesis):
In SLE, autoantibody-mediated pathology is primarily due to:
A) Cell-mediated cytotoxicity
B) Formation of antigen-antibody immune complexes (type III hypersensitivity)
C) Direct bacterial infection
D) Complement deficiency
E) Amyloid deposition
B) Formation of antigen-antibody immune complexes (type III hypersensitivity)
Rationale: SLE is a type III hypersensitivity with immune complex deposition
4
SUCCESS!
Rheumatology Module 1 Synovial Joint
Classification and Microanatomy -LJM TBL 1 EXAM
WITH COMPLETE QUESTIONS AND CORRECT
VERIFIED ANSWERS LATEST UPDATE JUST
RELEASED THIS YEAR
1(Cell types):
Which cell is responsible for maintaining the extracellular matrix of articular cartilage?
A) Osteoblast
B) Fibroblast
C) Chondrocyte
D) Synoviocyte
E) Osteoclast
C) Chondrocyte
Rationale: Chondrocytes are the main cell of cartilage, maintaining ECM
2 (Disease mechanism):
Which is the earliest event in the pathogenesis of osteoarthritis following joint injury?
A) Osteonecrosis
B) Chondral fracture
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C) Chondrocyte apoptosis
D) Formation of pannus
E) Amyloid deposition
C) Chondrocyte apoptosis
Rationale: Chondrocyte death is an early response to cartilage injury, leading to OA
3 (Visual):
A gross pathology image shows a loose fragment within the knee joint after patella
dislocation. This is most consistent with:
A) Chondral fracture
B) Osteochondral fracture
C) Osteonecrosis
D) Synovitis
E) Gout
B) Osteochondral fracture
Rationale: An osteochondral fracture involves cartilage and bone, often after patellar dislocation
4 (Disease):
A teenager presents with joint pain and MRI reveals a bone fragment separating from the
femoral condyle, with underlying bone sclerosis. Most likely diagnosis?
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A) Osteochondritis dissecans
B) Chondromalacia
C) Osteonecrosis
D) Scurvy
E) Rheumatoid arthritis
A) Osteochondritis dissecans
Rationale: Osteochondritis dissecans = separation of osteochondral fragment, sclerosis in
subchondral bone
Autoimmune Rheumatic Disease: Granular and Clinical
4 (Autoantibody panel):
Which autoantibody is recommended for initial screening in suspected SLE?
A) Anti-CCP
B) Anti-dsDNA
C) Rheumatoid factor
D) Antinuclear antibody (ANA)
E) Anti-RNP
D) Antinuclear antibody (ANA)
Rationale: ANA is sensitive for SLE and is used for initial screening; anti-dsDNA is more specific
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5 (Trap):
Which connective tissue disease is NOT associated with anti-nuclear antibodies as a key
diagnostic marker?
A) Systemic lupus erythematosus
B) Sjögren's syndrome
C) Scleroderma
D) Rheumatoid arthritis
E) Osteoarthritis
E) Osteoarthritis
Rationale: OA is non-inflammatory and not associated with ANAs; the others are autoimmune
4 (Pathogenesis):
In SLE, autoantibody-mediated pathology is primarily due to:
A) Cell-mediated cytotoxicity
B) Formation of antigen-antibody immune complexes (type III hypersensitivity)
C) Direct bacterial infection
D) Complement deficiency
E) Amyloid deposition
B) Formation of antigen-antibody immune complexes (type III hypersensitivity)
Rationale: SLE is a type III hypersensitivity with immune complex deposition
4
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