Exam 1 v1: NSG552 / NSG 552 (Latest
Update) Psychopharmacology | Questions and
Verified Answers | 100% Correct | Grade A -
Wilkes
What are the 6 general principles of psychopharmacological treatment?
Safety
Tolerability
Efficacy
Practicality
Treatment accessibility
Treatment compliance
Pharmacokinetics
How the drug moves in the body. (ex. Where is it absorbed? How and where is it metabolized?
Where is it excreted?)
Pharmacodynamics
What the drug does to the body. (consider mechanism of action)
Define First-generation antipsychotics
Referred to as Typical Antipsychotics. Most have strong bond with D2 receptors only, cause EPS
symptoms faster due to prolonged receptor dissociation, have more dangerous side effect
profiles, have been around longer, more effective at treating positive symptoms, less expensive.
(Ex. Haloperidol, Chlorpromazine, Thioridazine, Fluphenazine)
, Exam 1 v1: NSG552 / NSG 552 (Latest
Update) Psychopharmacology | Questions and
Verified Answers | 100% Correct | Grade A -
Wilkes
Define Second-generation antipsychotics
Referred to as Atypical Antipsychotics. Most have a weak bond with D2 receptors and block
serotonin receptors leading to anti-depressive and anxiolytic effects. They cause less EPS due to
rapid receptor disassociation which leads to rapid dopamine neurotransmission. Have less
dangerous side effect profiles but can cause metabolic syndromes, have been around shorter
time, more expensive, more effective at treating negative symptoms but can treat positive
symptoms as well, long-acting injections available for several of these. (Ex. Risperidone,
Clozapine, Quetiapine, Aripiprazole, Ziprasidone)
Extra Pyramidal Symptoms (EPS)
Side effects caused by certain antipsychotic medications, which include: involuntary or
uncontrollable movements. tremors. muscle contractions.
Tardive dyskinesia
A neurological disorder characterize by involuntary movement of the face and jaw.
Upregulation
Occurs through chronic use of antagonists which causes an increase in the number of receptors,
externalization of receptors, and increased sensitivity of the receptors. Prolonged use of
antagonist -> Up-regulation of receptors -> Sudden withdrawal of antagonist -> increased
, Exam 1 v1: NSG552 / NSG 552 (Latest
Update) Psychopharmacology | Questions and
Verified Answers | 100% Correct | Grade A -
Wilkes
number of receptors and increased sensitivity of receptors *YOU MUST GRADUALLY TAPER
A DRUG TO AVOID BINDING TO ALL NEW RECEPTORS FROM UPREGULATION
Down regulation
Occurs by chronic exposure of agonists which causes decreased number of receptors,
internalization of receptors, and decreased sensitivity of the receptors. Prolonged use of agonist -
> down-regulation of receptors -> decreased effectiveness of agonist mediated clinical response.
You have two options:
1 Increase the drug dose OR 2 Switch to another drug(BEST OPTION)
Receptor profile
The receptors that each drug binds to
(example, risperidone's receptor profile would like...
(a) Blockade of 5HT2A and D2 receptors
(b) High affinity for a1, a2, and H1 receptors)
Binding
Refers to a drug metabolite or neurotransmitter attaching to a receptor
Update) Psychopharmacology | Questions and
Verified Answers | 100% Correct | Grade A -
Wilkes
What are the 6 general principles of psychopharmacological treatment?
Safety
Tolerability
Efficacy
Practicality
Treatment accessibility
Treatment compliance
Pharmacokinetics
How the drug moves in the body. (ex. Where is it absorbed? How and where is it metabolized?
Where is it excreted?)
Pharmacodynamics
What the drug does to the body. (consider mechanism of action)
Define First-generation antipsychotics
Referred to as Typical Antipsychotics. Most have strong bond with D2 receptors only, cause EPS
symptoms faster due to prolonged receptor dissociation, have more dangerous side effect
profiles, have been around longer, more effective at treating positive symptoms, less expensive.
(Ex. Haloperidol, Chlorpromazine, Thioridazine, Fluphenazine)
, Exam 1 v1: NSG552 / NSG 552 (Latest
Update) Psychopharmacology | Questions and
Verified Answers | 100% Correct | Grade A -
Wilkes
Define Second-generation antipsychotics
Referred to as Atypical Antipsychotics. Most have a weak bond with D2 receptors and block
serotonin receptors leading to anti-depressive and anxiolytic effects. They cause less EPS due to
rapid receptor disassociation which leads to rapid dopamine neurotransmission. Have less
dangerous side effect profiles but can cause metabolic syndromes, have been around shorter
time, more expensive, more effective at treating negative symptoms but can treat positive
symptoms as well, long-acting injections available for several of these. (Ex. Risperidone,
Clozapine, Quetiapine, Aripiprazole, Ziprasidone)
Extra Pyramidal Symptoms (EPS)
Side effects caused by certain antipsychotic medications, which include: involuntary or
uncontrollable movements. tremors. muscle contractions.
Tardive dyskinesia
A neurological disorder characterize by involuntary movement of the face and jaw.
Upregulation
Occurs through chronic use of antagonists which causes an increase in the number of receptors,
externalization of receptors, and increased sensitivity of the receptors. Prolonged use of
antagonist -> Up-regulation of receptors -> Sudden withdrawal of antagonist -> increased
, Exam 1 v1: NSG552 / NSG 552 (Latest
Update) Psychopharmacology | Questions and
Verified Answers | 100% Correct | Grade A -
Wilkes
number of receptors and increased sensitivity of receptors *YOU MUST GRADUALLY TAPER
A DRUG TO AVOID BINDING TO ALL NEW RECEPTORS FROM UPREGULATION
Down regulation
Occurs by chronic exposure of agonists which causes decreased number of receptors,
internalization of receptors, and decreased sensitivity of the receptors. Prolonged use of agonist -
> down-regulation of receptors -> decreased effectiveness of agonist mediated clinical response.
You have two options:
1 Increase the drug dose OR 2 Switch to another drug(BEST OPTION)
Receptor profile
The receptors that each drug binds to
(example, risperidone's receptor profile would like...
(a) Blockade of 5HT2A and D2 receptors
(b) High affinity for a1, a2, and H1 receptors)
Binding
Refers to a drug metabolite or neurotransmitter attaching to a receptor
